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Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition.
Br J Cancer 2006; 95(3):406-15BJ

Abstract

Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC.

Authors+Show Affiliations

Nutrition and Hormones Group, IARC-WHO, Lyon, France. Jenab@iarc.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16832408

Citation

Jenab, M, et al. "Plasma and Dietary Carotenoid, Retinol and Tocopherol Levels and the Risk of Gastric Adenocarcinomas in the European Prospective Investigation Into Cancer and Nutrition." British Journal of Cancer, vol. 95, no. 3, 2006, pp. 406-15.
Jenab M, Riboli E, Ferrari P, et al. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition. Br J Cancer. 2006;95(3):406-15.
Jenab, M., Riboli, E., Ferrari, P., Friesen, M., Sabate, J., Norat, T., ... Gonzalez, C. A. (2006). Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition. British Journal of Cancer, 95(3), pp. 406-15.
Jenab M, et al. Plasma and Dietary Carotenoid, Retinol and Tocopherol Levels and the Risk of Gastric Adenocarcinomas in the European Prospective Investigation Into Cancer and Nutrition. Br J Cancer. 2006 Aug 7;95(3):406-15. PubMed PMID: 16832408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition. AU - Jenab,M, AU - Riboli,E, AU - Ferrari,P, AU - Friesen,M, AU - Sabate,J, AU - Norat,T, AU - Slimani,N, AU - Tjønneland,A, AU - Olsen,A, AU - Overvad,K, AU - Boutron-Ruault,M-C, AU - Clavel-Chapelon,F, AU - Boeing,H, AU - Schulz,M, AU - Linseisen,J, AU - Nagel,G, AU - Trichopoulou,A, AU - Naska,A, AU - Oikonomou,E, AU - Berrino,F, AU - Panico,S, AU - Palli,D, AU - Sacerdote,C, AU - Tumino,R, AU - Peeters,P H, AU - Numans,M E, AU - Bueno-de-Mesquita,H B, AU - Büchner,F L, AU - Lund,E, AU - Pera,G, AU - Chirlaque,M D, AU - Sánchez,M-J, AU - Arriola,L, AU - Barricarte,A, AU - Quirós,J R, AU - Johansson,I, AU - Johansson,A, AU - Berglund,G, AU - Bingham,S, AU - Khaw,K-T, AU - Allen,N, AU - Key,T, AU - Carneiro,F, AU - Save,V, AU - Del Giudice,G, AU - Plebani,M, AU - Kaaks,R, AU - Gonzalez,C A, Y1 - 2006/07/11/ PY - 2006/7/13/pubmed PY - 2006/12/9/medline PY - 2006/7/13/entrez SP - 406 EP - 15 JF - British journal of cancer JO - Br. J. Cancer VL - 95 IS - 3 N2 - Despite declining incidence rates, gastric cancer (GC) is a major cause of death worldwide. Its aetiology may involve dietary antioxidant micronutrients such as carotenoids and tocopherols. The objective of this study was to determine the association of plasma levels of seven common carotenoids, their total plasma concentration, retinol and alpha- and gamma-tocopherol, with the risk of gastric adenocarcinoma in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC), a large cohort involving 10 countries. A secondary objective was to determine the association of total sum of carotenoids, retinol and alpha-tocopherol on GCs by anatomical subsite (cardia/noncardia) and histological subtype (diffuse/intestinal). Analytes were measured by high-performance liquid chromatography in prediagnostic plasma from 244 GC cases and 645 controls matched by age, gender, study centre and date of blood donation. Conditional logistic regression models adjusted by body mass index, total energy intake, smoking and Helicobacter pylori infection status were used to estimate relative cancer risks. After an average 3.2 years of follow-up, a negative association with GC risk was observed in the highest vs the lowest quartiles of plasma beta-cryptoxanthin (odds ratio (OR) = 0.53, 95% confidence intervals (CI) = 0.30-0.94, P(trend) = 0.006), zeaxanthin (OR = 0.39, 95% CI = 0.22-0.69, P(trend) = 0.005), retinol (OR = 0.55, 95% CI = 0.33-0.93, P(trend) = 0.005) and lipid-unadjusted alpha-tocopherol (OR = 0.59, 95% CI = 0.37-0.94, P(trend) = 0.022). For all analytes, no heterogeneity of risk estimates or significant associations were observed by anatomical subsite. In the diffuse histological subtype, an inverse association was observed with the highest vs lowest quartile of lipid-unadjusted alpha-tocopherol (OR = 0.26, 95% CI = 0.11-0.65, P(trend) = 0.003). These results show that higher plasma concentrations of some carotenoids, retinol and alpha-tocopherol are associated with reduced risk of GC. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/16832408/Plasma_and_dietary_carotenoid_retinol_and_tocopherol_levels_and_the_risk_of_gastric_adenocarcinomas_in_the_European_prospective_investigation_into_cancer_and_nutrition_ L2 - http://dx.doi.org/10.1038/sj.bjc.6603266 DB - PRIME DP - Unbound Medicine ER -