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Pituitary apoplexy after leuprolide.
Pituitary. 2006; 9(3):263-5.P

Abstract

Clinically unsuspected pituitary adenomas are common among adults on autopsy and MRI survey. Acute pituitary hemorrhage is far more rare. We report a case of a 61-year-old male patient with locally advanced prostate cancer who presented with an acute picture of pituitary apoplexy after his first dose of leuprolide. He developed headache and neck pain within a few hours of treatment followed by nausea, vomiting, ptosis and diplopia. Pituitary apoplexy is a potentially life threatening medical emergency. Although the pathophysiology is poorly defined, various conditions and treatments have been reported to trigger apoplexy. Apoplexy has been reported in response to pituitary stimulation by GnRH or GnRH-agonists. Initial stimulatory effects of gonadotropin releasing hormone (GnRH) analogue may induce apoplexy in patients with asymptomatic gonadotroph adenomas.

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Authors+Show Affiliations

Davis A
University of Texas Health Science Center - Houston, 6431 Fannin, MSB 4.202, Houston, TX 77030, USA. anudavis@alumni.utexas.net
Goel S
No affiliation info available
Picolos M
No affiliation info available
Wang M
No affiliation info available
Lavis V
No affiliation info available

MeSH

AdenomaAntineoplastic Agents, HormonalGonadotropin-Releasing HormoneHumansHypophysectomyLeuprolideMagnetic Resonance ImagingMaleMiddle AgedPituitary ApoplexyPituitary NeoplasmsProstatic NeoplasmsRisk FactorsTreatment Outcome

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16832587

Citation

Davis, Anu, et al. "Pituitary Apoplexy After Leuprolide." Pituitary, vol. 9, no. 3, 2006, pp. 263-5.
Davis A, Goel S, Picolos M, et al. Pituitary apoplexy after leuprolide. Pituitary. 2006;9(3):263-5.
Davis, A., Goel, S., Picolos, M., Wang, M., & Lavis, V. (2006). Pituitary apoplexy after leuprolide. Pituitary, 9(3), 263-5.
Davis A, et al. Pituitary Apoplexy After Leuprolide. Pituitary. 2006;9(3):263-5. PubMed PMID: 16832587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pituitary apoplexy after leuprolide. AU - Davis,Anu, AU - Goel,Shefali, AU - Picolos,Michalis, AU - Wang,Min, AU - Lavis,Victor, PY - 2006/7/13/pubmed PY - 2009/6/12/medline PY - 2006/7/13/entrez SP - 263 EP - 5 JF - Pituitary JO - Pituitary VL - 9 IS - 3 N2 - Clinically unsuspected pituitary adenomas are common among adults on autopsy and MRI survey. Acute pituitary hemorrhage is far more rare. We report a case of a 61-year-old male patient with locally advanced prostate cancer who presented with an acute picture of pituitary apoplexy after his first dose of leuprolide. He developed headache and neck pain within a few hours of treatment followed by nausea, vomiting, ptosis and diplopia. Pituitary apoplexy is a potentially life threatening medical emergency. Although the pathophysiology is poorly defined, various conditions and treatments have been reported to trigger apoplexy. Apoplexy has been reported in response to pituitary stimulation by GnRH or GnRH-agonists. Initial stimulatory effects of gonadotropin releasing hormone (GnRH) analogue may induce apoplexy in patients with asymptomatic gonadotroph adenomas. SN - 1573-7403 UR - https://www.unboundmedicine.com/medline/citation/16832587/Pituitary_apoplexy_after_leuprolide_ L2 - https://doi.org/10.1007/s11102-006-8616-6 DB - PRIME DP - Unbound Medicine ER -