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Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde.
Arch Pharm Res. 2006 Jun; 29(6):520-4.AP

Abstract

Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded cross-linked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen.

Authors+Show Affiliations

College of Pharmacy, Yeungnam University, Gyongsan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16833022

Citation

Yong, Chul-Soon, et al. "Retarded Dissolution of Ibuprofen in Gelatin Microcapsule By Cross-linking With Glutaradehyde." Archives of Pharmacal Research, vol. 29, no. 6, 2006, pp. 520-4.
Yong CS, Li DX, Oh DH, et al. Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde. Arch Pharm Res. 2006;29(6):520-4.
Yong, C. S., Li, D. X., Oh, D. H., Kim, J. A., Yoo, B. K., Woo, J. S., Rhee, J. D., & Choi, H. G. (2006). Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde. Archives of Pharmacal Research, 29(6), 520-4.
Yong CS, et al. Retarded Dissolution of Ibuprofen in Gelatin Microcapsule By Cross-linking With Glutaradehyde. Arch Pharm Res. 2006;29(6):520-4. PubMed PMID: 16833022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retarded dissolution of ibuprofen in gelatin microcapsule by cross-linking with glutaradehyde. AU - Yong,Chul-Soon, AU - Li,Dong-Xun, AU - Oh,Dong-Hoon, AU - Kim,Jung-Ae, AU - Yoo,Bong-Kyu, AU - Woo,Jong-Soo, AU - Rhee,Jong-Dal, AU - Choi,Han-Gon, PY - 2006/7/13/pubmed PY - 2006/9/26/medline PY - 2006/7/13/entrez SP - 520 EP - 4 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 29 IS - 6 N2 - Ibuprofen-loaded gelatin microcapsule, a solid form of microcapsules simultaneously containing ethanol and ibuprofen in water-soluble gelatin shell was previously reported to improve the dissolution of drug. In this study, to retard the initial high dissolution of ibuprofen from gelatin microcapsule, the ibuprofen-loaded cross-linked gelatin microcapsule was prepared by treating an ibuprofen-loaded gelatin microcapsule with glutaraldehyde and its dissolution was evaluated compared to ibuprofen powder and gelatin microcapsule. The ibuprofen-loaded cross-linked microcapsule treated with glutaraldehyde for 10 and 60 sec gave significantly higher dissolution rates than did ibuprofen powder. Furthermore, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 10 sec was similar to that from gelatin microcapsule. However, the dissolution rate of ibuprofen from the cross-linked microcapsule treated for 60 sec decreased significantly compared to gelatin microcapsule, suggesting that the treatment of gelatin microcapsule with glutaraldehyde for 60 sec could cross-link the gelatin microcapsule. Furthermore, the cross-linking of gelatin microcapsule markedly retarded the release rate of ibuprofen in pH 1.2 simulated gastric fluid compared to gelatin microcapsule. However, the cross-linking of gelatin microcapsule with glutaraldehyde hardly changed the size of gelatin microcapsules, ethanol and ibuprofen contents encapsulated in gelatin microcapsule. Thus, the ibuprofen-loaded cross-linked gelatin microcapsule could retard the initial high dissolution of poorly water-soluble ibuprofen. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/16833022/Retarded_dissolution_of_ibuprofen_in_gelatin_microcapsule_by_cross_linking_with_glutaradehyde_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=16833022.ui DB - PRIME DP - Unbound Medicine ER -