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Stroke prevention and statin treatment.

Abstract

Randomized trials with statins have shown a modest but significant absolute reduction in the incidence of stroke in patients with a previous myocardial infarction. The reasons for the positive statin effect on stroke endpoint are unclear, because a link between serum cholesterol level and stroke never has been established. However, positive results of statin trials were mainly obtained in patients with an average or a low serum cholesterol level. Statins have a good overall safety profile. Statins reduced stroke incidence in high-risk (mainly coronary heart disease, diabetics, and hypertensives) population even with a normal baseline blood cholesterol level. In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention.

Authors+Show Affiliations

,

Department of Neuroscience, University of Perugia, Perugia, Italy. parnetti@unipg.it

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Source

MeSH

Clinical Trials as Topic
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipidemias
Incidence
Stroke
Survival Rate
Treatment Outcome

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16833043

Citation

Parnetti, Lucilla, et al. "Stroke Prevention and Statin Treatment." Clinical and Experimental Hypertension (New York, N.Y. : 1993), vol. 28, no. 3-4, 2006, pp. 335-44.
Parnetti L, Caso V, Lanari A, et al. Stroke prevention and statin treatment. Clin Exp Hypertens. 2006;28(3-4):335-44.
Parnetti, L., Caso, V., Lanari, A., Saggese, E., Sebastianelli, M., Tayebati, S. K., & Amenta, F. (2006). Stroke prevention and statin treatment. Clinical and Experimental Hypertension (New York, N.Y. : 1993), 28(3-4), pp. 335-44.
Parnetti L, et al. Stroke Prevention and Statin Treatment. Clin Exp Hypertens. 2006;28(3-4):335-44. PubMed PMID: 16833043.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stroke prevention and statin treatment. AU - Parnetti,Lucilla, AU - Caso,Valeria, AU - Lanari,Alessia, AU - Saggese,Emanuele, AU - Sebastianelli,Michela, AU - Tayebati,Seyed Khosrow, AU - Amenta,Francesco, PY - 2006/7/13/pubmed PY - 2006/7/28/medline PY - 2006/7/13/entrez SP - 335 EP - 44 JF - Clinical and experimental hypertension (New York, N.Y. : 1993) JO - Clin. Exp. Hypertens. VL - 28 IS - 3-4 N2 - Randomized trials with statins have shown a modest but significant absolute reduction in the incidence of stroke in patients with a previous myocardial infarction. The reasons for the positive statin effect on stroke endpoint are unclear, because a link between serum cholesterol level and stroke never has been established. However, positive results of statin trials were mainly obtained in patients with an average or a low serum cholesterol level. Statins have a good overall safety profile. Statins reduced stroke incidence in high-risk (mainly coronary heart disease, diabetics, and hypertensives) population even with a normal baseline blood cholesterol level. In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention. SN - 1064-1963 UR - https://www.unboundmedicine.com/medline/citation/16833043/Stroke_prevention_and_statin_treatment_ L2 - https://medlineplus.gov/cholesterolmedicines.html DB - PRIME DP - Unbound Medicine ER -