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Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study.
Eur Heart J. 2006 Aug; 27(16):1971-8.EH

Abstract

AIMS

Carotid intima-media thickness (CIMT) is an independent predictor of vascular events in the general population. Currently, little is known about the relationship between CIMT and new vascular events in patients with manifest arterial disease. We aimed to assess the strength of this relationship.

METHODS AND RESULTS

The study was performed in the first consecutive 2374 patients with manifest arterial disease enrolled in the cohort study SMART (Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common CIMT was measured at baseline in both carotid arteries. Vascular events were vascular death, non-fatal myocardial infarction, or stroke, whichever occurred first. Adjusted for age and sex, an increase in common CIMT of 1 SD (approximately 0.32 mm) was associated with the occurrence of vascular events [hazard ratio (HR) 1.18; 95% confidence interval (95% CI) 1.04-1.32]. Increasing CIMT was most strongly related to ischaemic stroke incidence (HR 1.35; 95% CI 1.16-1.59). Results were similar in the 2177 patients without large common carotid plaques (CIMT <2 mm at all measurements sites). The findings were similar after additional adjustment for risk factors of CIMT and vascular risk.

CONCLUSION

Common CIMT is associated with the occurrence of new vascular events, mostly for ischaemic stroke, in patients with manifest arterial disease. This relation does not appear to depend on the presence of plaques.

Authors+Show Affiliations

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str. 6.131, PO Box 85060, 3508 BA Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16835264

Citation

Dijk, Joke M., et al. "Carotid Intima-media Thickness and the Risk of New Vascular Events in Patients With Manifest Atherosclerotic Disease: the SMART Study." European Heart Journal, vol. 27, no. 16, 2006, pp. 1971-8.
Dijk JM, van der Graaf Y, Bots ML, et al. Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study. Eur Heart J. 2006;27(16):1971-8.
Dijk, J. M., van der Graaf, Y., Bots, M. L., Grobbee, D. E., & Algra, A. (2006). Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study. European Heart Journal, 27(16), 1971-8.
Dijk JM, et al. Carotid Intima-media Thickness and the Risk of New Vascular Events in Patients With Manifest Atherosclerotic Disease: the SMART Study. Eur Heart J. 2006;27(16):1971-8. PubMed PMID: 16835264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study. AU - Dijk,Joke M, AU - van der Graaf,Yolanda, AU - Bots,Michiel L, AU - Grobbee,Diederick E, AU - Algra,Ale, Y1 - 2006/07/11/ PY - 2006/7/13/pubmed PY - 2007/1/9/medline PY - 2006/7/13/entrez SP - 1971 EP - 8 JF - European heart journal JO - Eur Heart J VL - 27 IS - 16 N2 - AIMS: Carotid intima-media thickness (CIMT) is an independent predictor of vascular events in the general population. Currently, little is known about the relationship between CIMT and new vascular events in patients with manifest arterial disease. We aimed to assess the strength of this relationship. METHODS AND RESULTS: The study was performed in the first consecutive 2374 patients with manifest arterial disease enrolled in the cohort study SMART (Second Manifestations of ARTerial disease), a cohort study among patients with manifest arterial disease or cardiovascular risk factors. Common CIMT was measured at baseline in both carotid arteries. Vascular events were vascular death, non-fatal myocardial infarction, or stroke, whichever occurred first. Adjusted for age and sex, an increase in common CIMT of 1 SD (approximately 0.32 mm) was associated with the occurrence of vascular events [hazard ratio (HR) 1.18; 95% confidence interval (95% CI) 1.04-1.32]. Increasing CIMT was most strongly related to ischaemic stroke incidence (HR 1.35; 95% CI 1.16-1.59). Results were similar in the 2177 patients without large common carotid plaques (CIMT <2 mm at all measurements sites). The findings were similar after additional adjustment for risk factors of CIMT and vascular risk. CONCLUSION: Common CIMT is associated with the occurrence of new vascular events, mostly for ischaemic stroke, in patients with manifest arterial disease. This relation does not appear to depend on the presence of plaques. SN - 0195-668X UR - https://www.unboundmedicine.com/medline/citation/16835264/Carotid_intima_media_thickness_and_the_risk_of_new_vascular_events_in_patients_with_manifest_atherosclerotic_disease:_the_SMART_study_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehl136 DB - PRIME DP - Unbound Medicine ER -