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Folate intake and stomach cancer incidence in a prospective cohort of Swedish women.
Cancer Epidemiol Biomarkers Prev 2006; 15(7):1409-12CE

Abstract

BACKGROUND

Experimental and epidemiologic evidence suggests that folate may play a role in the development of some cancers. Case-control studies and one prospective cohort study on folate intake in relation to stomach cancer risk have yielded inconsistent results.

METHODS

We prospectively investigated the relation between folate intake and the incidence of stomach cancer among 61,433 women in the Swedish Mammography Cohort. Participants completed a food frequency questionnaire at baseline (1987-1990) and again in 1997. During follow-up through December 2004, 156 incident stomach cancer cases were diagnosed. Cox proportional hazards models were used to calculate multivariate-adjusted hazard ratios.

RESULTS

There was no association between dietary folate intake (i.e., folate from food sources) and the risk of stomach cancer. The multivariate hazard ratio for the highest compared with the lowest category of updated average dietary folate intake was 1.04 (95% confidence interval, 0.61-1.86; P(trend) = 0.91). The relation between dietary folate intake and stomach cancer did not vary significantly by intake of alcohol, methionine, or caffeine.

CONCLUSION

Results from this prospective study do not support an association between dietary folate intake and risk of stomach cancer.

Authors+Show Affiliations

Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16835345

Citation

Larsson, Susanna C., et al. "Folate Intake and Stomach Cancer Incidence in a Prospective Cohort of Swedish Women." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 7, 2006, pp. 1409-12.
Larsson SC, Giovannucci E, Wolk A. Folate intake and stomach cancer incidence in a prospective cohort of Swedish women. Cancer Epidemiol Biomarkers Prev. 2006;15(7):1409-12.
Larsson, S. C., Giovannucci, E., & Wolk, A. (2006). Folate intake and stomach cancer incidence in a prospective cohort of Swedish women. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(7), pp. 1409-12.
Larsson SC, Giovannucci E, Wolk A. Folate Intake and Stomach Cancer Incidence in a Prospective Cohort of Swedish Women. Cancer Epidemiol Biomarkers Prev. 2006;15(7):1409-12. PubMed PMID: 16835345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate intake and stomach cancer incidence in a prospective cohort of Swedish women. AU - Larsson,Susanna C, AU - Giovannucci,Edward, AU - Wolk,Alicja, PY - 2006/7/13/pubmed PY - 2006/11/15/medline PY - 2006/7/13/entrez SP - 1409 EP - 12 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 15 IS - 7 N2 - BACKGROUND: Experimental and epidemiologic evidence suggests that folate may play a role in the development of some cancers. Case-control studies and one prospective cohort study on folate intake in relation to stomach cancer risk have yielded inconsistent results. METHODS: We prospectively investigated the relation between folate intake and the incidence of stomach cancer among 61,433 women in the Swedish Mammography Cohort. Participants completed a food frequency questionnaire at baseline (1987-1990) and again in 1997. During follow-up through December 2004, 156 incident stomach cancer cases were diagnosed. Cox proportional hazards models were used to calculate multivariate-adjusted hazard ratios. RESULTS: There was no association between dietary folate intake (i.e., folate from food sources) and the risk of stomach cancer. The multivariate hazard ratio for the highest compared with the lowest category of updated average dietary folate intake was 1.04 (95% confidence interval, 0.61-1.86; P(trend) = 0.91). The relation between dietary folate intake and stomach cancer did not vary significantly by intake of alcohol, methionine, or caffeine. CONCLUSION: Results from this prospective study do not support an association between dietary folate intake and risk of stomach cancer. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16835345/Folate_intake_and_stomach_cancer_incidence_in_a_prospective_cohort_of_Swedish_women_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=16835345 DB - PRIME DP - Unbound Medicine ER -