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The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene.
Eur J Clin Nutr. 2007 Jan; 61(1):69-76.EJ

Abstract

OBJECTIVE

To investigate the contribution of the total antioxidant capacity (TAC) of the diet to plasma concentrations of beta-carotene.

DESIGN

Cross-sectional study.

SETTING

Department of Public Health and Department of Internal Medicine and Biomedical Sciences, University of Parma.

SUBJECTS

A total of 247 apparently healthy adult men (n=140) and women (n=107).

METHODS

A medical history, a physical exam including height, weight, waist circumference and blood pressure measurements, a fasting blood draw, an oral glucose tolerance test and a 3-day food record.

RESULTS

We observe a negative trend across quartiles of plasma beta-carotene for most biological variables clustering in the insulin resistance syndrome, as well as for traditional and new risk factors for type II diabetes and cardiovascular disease (CVD), including C-reactive protein and gamma-glutamyltranspeptidase (P<0.05). Regarding dietary characteristics, energy-adjusted intake of fat, fiber, fruits, vegetables, beta-carotene, vitamin C, vitamin E and dietary TAC significantly increased with increasing plasma beta-carotene (P<0.05), whereas alcohol intake decreased (P=0.013). Adjusted geometric means (95% confidence interval) of plasma beta-carotene significantly increased across quartiles of dietary TAC, even when single dietary antioxidants were considered in the model (QI=0.087 mg/dl (0.073-0.102); QII=0.087 mg/dl (0.075-0.103); QIII=0.114 mg/dl (0.098-0.132) and QIV=0.110 mg/dl (0.093-0.130); P for linear trend=0.026). When the population was divided on the basis of alcohol consumption, this trend was also observed in subjects drinking <20 g alcohol/day (P=0.034), but not in those with higher alcohol intake (P=0.448).

CONCLUSIONS

Dietary TAC is an independent predictor of plasma beta-carotene, especially in moderate alcohol drinkers. This may explain, at least in part, the inverse relationship observed between plasma beta-carotene and risk of chronic diseases associated to high levels of oxidative stress (i.e., diabetes and CVD), as well as the failure of beta-carotene supplements alone in reducing such risk.

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Authors+Show Affiliations

Valtueña S
Department of Public Health, University of Parma, Parma, Italy. valtuena@libero.it
Del Rio D
No affiliation info available
Pellegrini N
No affiliation info available
Ardigò D
No affiliation info available
Franzini L
No affiliation info available
Salvatore S
No affiliation info available
Piatti PM
No affiliation info available
Riso P
No affiliation info available
Zavaroni I
No affiliation info available
Brighenti F
No affiliation info available

MeSH

Alcohol DrinkingAntioxidantsCardiovascular DiseasesCluster AnalysisCohort StudiesCross-Sectional StudiesDiabetes Mellitus, Type 2DietFemaleFood AnalysisHumansInsulin ResistanceMaleMetabolic SyndromeMiddle AgedOxidation-ReductionOxidative StressPredictive Value of TestsRisk FactorsVitaminsbeta Carotene

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16835597

Citation

Valtueña, S, et al. "The Total Antioxidant Capacity of the Diet Is an Independent Predictor of Plasma Beta-carotene." European Journal of Clinical Nutrition, vol. 61, no. 1, 2007, pp. 69-76.
Valtueña S, Del Rio D, Pellegrini N, et al. The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. Eur J Clin Nutr. 2007;61(1):69-76.
Valtueña, S., Del Rio, D., Pellegrini, N., Ardigò, D., Franzini, L., Salvatore, S., Piatti, P. M., Riso, P., Zavaroni, I., & Brighenti, F. (2007). The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. European Journal of Clinical Nutrition, 61(1), 69-76.
Valtueña S, et al. The Total Antioxidant Capacity of the Diet Is an Independent Predictor of Plasma Beta-carotene. Eur J Clin Nutr. 2007;61(1):69-76. PubMed PMID: 16835597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The total antioxidant capacity of the diet is an independent predictor of plasma beta-carotene. AU - Valtueña,S, AU - Del Rio,D, AU - Pellegrini,N, AU - Ardigò,D, AU - Franzini,L, AU - Salvatore,S, AU - Piatti,P M, AU - Riso,P, AU - Zavaroni,I, AU - Brighenti,F, Y1 - 2006/07/12/ PY - 2006/7/13/pubmed PY - 2007/2/28/medline PY - 2006/7/13/entrez SP - 69 EP - 76 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 61 IS - 1 N2 - OBJECTIVE: To investigate the contribution of the total antioxidant capacity (TAC) of the diet to plasma concentrations of beta-carotene. DESIGN: Cross-sectional study. SETTING: Department of Public Health and Department of Internal Medicine and Biomedical Sciences, University of Parma. SUBJECTS: A total of 247 apparently healthy adult men (n=140) and women (n=107). METHODS: A medical history, a physical exam including height, weight, waist circumference and blood pressure measurements, a fasting blood draw, an oral glucose tolerance test and a 3-day food record. RESULTS: We observe a negative trend across quartiles of plasma beta-carotene for most biological variables clustering in the insulin resistance syndrome, as well as for traditional and new risk factors for type II diabetes and cardiovascular disease (CVD), including C-reactive protein and gamma-glutamyltranspeptidase (P<0.05). Regarding dietary characteristics, energy-adjusted intake of fat, fiber, fruits, vegetables, beta-carotene, vitamin C, vitamin E and dietary TAC significantly increased with increasing plasma beta-carotene (P<0.05), whereas alcohol intake decreased (P=0.013). Adjusted geometric means (95% confidence interval) of plasma beta-carotene significantly increased across quartiles of dietary TAC, even when single dietary antioxidants were considered in the model (QI=0.087 mg/dl (0.073-0.102); QII=0.087 mg/dl (0.075-0.103); QIII=0.114 mg/dl (0.098-0.132) and QIV=0.110 mg/dl (0.093-0.130); P for linear trend=0.026). When the population was divided on the basis of alcohol consumption, this trend was also observed in subjects drinking <20 g alcohol/day (P=0.034), but not in those with higher alcohol intake (P=0.448). CONCLUSIONS: Dietary TAC is an independent predictor of plasma beta-carotene, especially in moderate alcohol drinkers. This may explain, at least in part, the inverse relationship observed between plasma beta-carotene and risk of chronic diseases associated to high levels of oxidative stress (i.e., diabetes and CVD), as well as the failure of beta-carotene supplements alone in reducing such risk. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16835597/The_total_antioxidant_capacity_of_the_diet_is_an_independent_predictor_of_plasma_beta_carotene_ L2 - https://doi.org/10.1038/sj.ejcn.1602485 DB - PRIME DP - Unbound Medicine ER -