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Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae).
Inflammopharmacology. 2006 Mar; 14(1-2):42-7.I

Abstract

Bridelia scleroneura is a member of the Euphorbiaceae family. In folk medicine in Cameroon, the stem bark of this plant is used for relieving abdominal pain, contortion, arthritis and inflammation. In this study, the antinociceptive and anti-inflammatory activities of the ethyl acetate stem bark extract have been evaluated. The putative analgesic effect of the plant extract was examined in abdominal constriction, hot plate, formalin and on pain using tail immersion mouse models and in carrageenan-induced paw edema in rats. The extract (150-600 mg/kg) exhibited a dose-dependent analgesic effect (46.27-78.97%) in acetic acid-induced abdominal constriction in mice. B. scleroneura extract increased the pain latency of nociceptive response to thermal stimuli at the higher dose of 600 mg/kg. B. scleroneuna induced significant dose-dependent reduction of the nociception in both early and late phases of the formalin test. The extract at the dose of 300 mg/kg, increased significantly, by 63.70% and 52.01% the tail-immersion latency time, 1 and 2 h post-dosing. In the carrageenan test, B. scleroneura (150-600 mg/kg, p.o) had dose-dependent and significant effects at different time intervals. This behaviour was similar to indometacin (10 mg/kg) used as a standard drug. These results show that the ethyl acetate stem bark extract of B. scleroneura possesses peripheral and central analgesic properties as well as anti-inflammatory activity against acute inflammation processes, in support of the folk medicinal use of the plant.

Authors+Show Affiliations

Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde I, Cameroon. tdimo@uycdc.uninet.cmNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16835712

Citation

Théophile, D, et al. "Antinociceptive and Anti-inflammatory Effects of the Ethyl Acetate Stem Bark Extract of Bridelia Scleroneura (Euphorbiaceae)." Inflammopharmacology, vol. 14, no. 1-2, 2006, pp. 42-7.
Théophile D, Laure NE, Benoît NT, et al. Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae). Inflammopharmacology. 2006;14(1-2):42-7.
Théophile, D., Laure, N. E., Benoît, N. T., Anatole, A. G., Emmanuel, A. A., Paul, T. V., & Pierre, K. (2006). Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae). Inflammopharmacology, 14(1-2), 42-7.
Théophile D, et al. Antinociceptive and Anti-inflammatory Effects of the Ethyl Acetate Stem Bark Extract of Bridelia Scleroneura (Euphorbiaceae). Inflammopharmacology. 2006;14(1-2):42-7. PubMed PMID: 16835712.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and anti-inflammatory effects of the ethyl acetate stem bark extract of Bridelia scleroneura (Euphorbiaceae). AU - Théophile,D, AU - Laure,N E, AU - Benoît,N T, AU - Anatole,A G B, AU - Emmanuel,A A, AU - Paul,T V, AU - Pierre,K, PY - 2005/06/27/received PY - 2005/11/07/accepted PY - 2006/7/13/pubmed PY - 2006/8/5/medline PY - 2006/7/13/entrez SP - 42 EP - 7 JF - Inflammopharmacology JO - Inflammopharmacology VL - 14 IS - 1-2 N2 - Bridelia scleroneura is a member of the Euphorbiaceae family. In folk medicine in Cameroon, the stem bark of this plant is used for relieving abdominal pain, contortion, arthritis and inflammation. In this study, the antinociceptive and anti-inflammatory activities of the ethyl acetate stem bark extract have been evaluated. The putative analgesic effect of the plant extract was examined in abdominal constriction, hot plate, formalin and on pain using tail immersion mouse models and in carrageenan-induced paw edema in rats. The extract (150-600 mg/kg) exhibited a dose-dependent analgesic effect (46.27-78.97%) in acetic acid-induced abdominal constriction in mice. B. scleroneura extract increased the pain latency of nociceptive response to thermal stimuli at the higher dose of 600 mg/kg. B. scleroneuna induced significant dose-dependent reduction of the nociception in both early and late phases of the formalin test. The extract at the dose of 300 mg/kg, increased significantly, by 63.70% and 52.01% the tail-immersion latency time, 1 and 2 h post-dosing. In the carrageenan test, B. scleroneura (150-600 mg/kg, p.o) had dose-dependent and significant effects at different time intervals. This behaviour was similar to indometacin (10 mg/kg) used as a standard drug. These results show that the ethyl acetate stem bark extract of B. scleroneura possesses peripheral and central analgesic properties as well as anti-inflammatory activity against acute inflammation processes, in support of the folk medicinal use of the plant. SN - 0925-4692 UR - https://www.unboundmedicine.com/medline/citation/16835712/Antinociceptive_and_anti_inflammatory_effects_of_the_ethyl_acetate_stem_bark_extract_of_Bridelia_scleroneura__Euphorbiaceae__ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -