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Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.
Mol Nutr Food Res. 2006 Aug; 50(8):739-45.MN

Abstract

The effects of three concentrations (0.2, 0.3, and 0.4 mg/mL) of a cinnamon extract (CE) (Cinnamomum zeylanicum) on glucose uptake and adiponectin secretion in 3T3-L1 adipocytes were examined in the presence and absence of 0.5 nM and 50 nM insulin. In the absence of insulin, adipocytes exposed to 0.2 mg/mL CE showed an approximate two-fold increase in glucose uptake relative to controls although glucose uptake was unaffected by the two higher concentrations of CE. No effect of CE on glucose uptake was noted in the presence of 0.5 nM insulin whereas the two highest concentrations (0.3 and 0.4 mg/mL) of CE showed a significant dose-dependent decrease in glucose uptake in the presence of 50 nM insulin. Treatment of the adipocytes with 50 nM wortmannin, an irreversible inhibitor of the p110 isoform of phosphoinositide 3'-kinase, was associated with complete inhibition of the stimulated glucose uptake induced by 0.2 mg/mL CE. Treatment of the adipocytes with 0.2 mg/mL CE was associated with an inhibition of adiponectin secretion to levels that were nondetectable. The present study indicates that although 0.2 mg/mL CE has insulin-mimetic action in 3T3-adipocytes in terms of glucose uptake, secretion of the antidiabetic hormone adiponectin is adversely affected.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, McGill University, Sainte Anne de Bellevue, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16835867

Citation

Roffey, Benjamin, et al. "Cinnamon Water Extracts Increase Glucose Uptake but Inhibit Adiponectin Secretion in 3T3-L1 Adipose Cells." Molecular Nutrition & Food Research, vol. 50, no. 8, 2006, pp. 739-45.
Roffey B, Atwal A, Kubow S. Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. Mol Nutr Food Res. 2006;50(8):739-45.
Roffey, B., Atwal, A., & Kubow, S. (2006). Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. Molecular Nutrition & Food Research, 50(8), 739-45.
Roffey B, Atwal A, Kubow S. Cinnamon Water Extracts Increase Glucose Uptake but Inhibit Adiponectin Secretion in 3T3-L1 Adipose Cells. Mol Nutr Food Res. 2006;50(8):739-45. PubMed PMID: 16835867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells. AU - Roffey,Benjamin, AU - Atwal,Avtar, AU - Kubow,Stan, PY - 2006/7/13/pubmed PY - 2006/10/6/medline PY - 2006/7/13/entrez SP - 739 EP - 45 JF - Molecular nutrition & food research JO - Mol Nutr Food Res VL - 50 IS - 8 N2 - The effects of three concentrations (0.2, 0.3, and 0.4 mg/mL) of a cinnamon extract (CE) (Cinnamomum zeylanicum) on glucose uptake and adiponectin secretion in 3T3-L1 adipocytes were examined in the presence and absence of 0.5 nM and 50 nM insulin. In the absence of insulin, adipocytes exposed to 0.2 mg/mL CE showed an approximate two-fold increase in glucose uptake relative to controls although glucose uptake was unaffected by the two higher concentrations of CE. No effect of CE on glucose uptake was noted in the presence of 0.5 nM insulin whereas the two highest concentrations (0.3 and 0.4 mg/mL) of CE showed a significant dose-dependent decrease in glucose uptake in the presence of 50 nM insulin. Treatment of the adipocytes with 50 nM wortmannin, an irreversible inhibitor of the p110 isoform of phosphoinositide 3'-kinase, was associated with complete inhibition of the stimulated glucose uptake induced by 0.2 mg/mL CE. Treatment of the adipocytes with 0.2 mg/mL CE was associated with an inhibition of adiponectin secretion to levels that were nondetectable. The present study indicates that although 0.2 mg/mL CE has insulin-mimetic action in 3T3-adipocytes in terms of glucose uptake, secretion of the antidiabetic hormone adiponectin is adversely affected. SN - 1613-4125 UR - https://www.unboundmedicine.com/medline/citation/16835867/Cinnamon_water_extracts_increase_glucose_uptake_but_inhibit_adiponectin_secretion_in_3T3_L1_adipose_cells_ L2 - https://doi.org/10.1002/mnfr.200500253 DB - PRIME DP - Unbound Medicine ER -