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The effect of modified citrus pectin on urinary excretion of toxic elements.
Phytother Res. 2006 Oct; 20(10):859-64.PR

Abstract

This study was undertaken to evaluate the effect of modified citrus pectin (MCP) on the urinary excretion of toxic elements in healthy individuals. MCP is a reduced molecular weight pectin (weight-average molar mass = 15,400) that is mostly linear homogalacturonan with a 3.8% degree of esterification and approximately 10% rhamnogalacturonan II based on the presence of 2-keto-3-deoxy-octonic acid. Subjects ingested 15 g of MCP (PectaSol, EcoNugenics Inc., Santa Rosa, California 95407) each day for 5 days and 20 g on day 6. Twenty-four hour urine samples were collected on day 1 and day 6 for comparison with baseline. The urine samples were analysed for toxic and essential elements. In the first 24 h of MCP administration the urinary excretion of arsenic increased significantly (130%, p < 0.05). On day 6, urinary excretion was increased significantly for cadmium (150%, p < 0.05). In addition, lead showed a dramatic increase in excretion (560%, p < 0.08). This pilot trial provides the first evidence that oral administration of MCP increases significantly the urinary excretion of toxic metals in subjects with a 'normal' body load of metals. It is suggested that systemic chelation of toxic metals by MCP may in part be attributable to the presence of rhamnogalacturonan II, which has been shown previously to chelate metals.

Authors+Show Affiliations

Amitabha Medical Clinic and Healing Center, 7064 Corline Ct. Ste A, Sebastopol, CA 95472, USA. ieliaz@prodigy.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16835878

Citation

Eliaz, Isaac, et al. "The Effect of Modified Citrus Pectin On Urinary Excretion of Toxic Elements." Phytotherapy Research : PTR, vol. 20, no. 10, 2006, pp. 859-64.
Eliaz I, Hotchkiss AT, Fishman ML, et al. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res. 2006;20(10):859-64.
Eliaz, I., Hotchkiss, A. T., Fishman, M. L., & Rode, D. (2006). The effect of modified citrus pectin on urinary excretion of toxic elements. Phytotherapy Research : PTR, 20(10), 859-64.
Eliaz I, et al. The Effect of Modified Citrus Pectin On Urinary Excretion of Toxic Elements. Phytother Res. 2006;20(10):859-64. PubMed PMID: 16835878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of modified citrus pectin on urinary excretion of toxic elements. AU - Eliaz,Isaac, AU - Hotchkiss,Arland T, AU - Fishman,Marshall L, AU - Rode,Dorena, PY - 2006/7/13/pubmed PY - 2007/1/4/medline PY - 2006/7/13/entrez SP - 859 EP - 64 JF - Phytotherapy research : PTR JO - Phytother Res VL - 20 IS - 10 N2 - This study was undertaken to evaluate the effect of modified citrus pectin (MCP) on the urinary excretion of toxic elements in healthy individuals. MCP is a reduced molecular weight pectin (weight-average molar mass = 15,400) that is mostly linear homogalacturonan with a 3.8% degree of esterification and approximately 10% rhamnogalacturonan II based on the presence of 2-keto-3-deoxy-octonic acid. Subjects ingested 15 g of MCP (PectaSol, EcoNugenics Inc., Santa Rosa, California 95407) each day for 5 days and 20 g on day 6. Twenty-four hour urine samples were collected on day 1 and day 6 for comparison with baseline. The urine samples were analysed for toxic and essential elements. In the first 24 h of MCP administration the urinary excretion of arsenic increased significantly (130%, p < 0.05). On day 6, urinary excretion was increased significantly for cadmium (150%, p < 0.05). In addition, lead showed a dramatic increase in excretion (560%, p < 0.08). This pilot trial provides the first evidence that oral administration of MCP increases significantly the urinary excretion of toxic metals in subjects with a 'normal' body load of metals. It is suggested that systemic chelation of toxic metals by MCP may in part be attributable to the presence of rhamnogalacturonan II, which has been shown previously to chelate metals. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/16835878/The_effect_of_modified_citrus_pectin_on_urinary_excretion_of_toxic_elements_ L2 - https://doi.org/10.1002/ptr.1953 DB - PRIME DP - Unbound Medicine ER -