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Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers.
Magn Reson Chem. 2006 Oct; 44(10):972-5.MR

Abstract

Assignments of 1H and 13C NMR chemical shifts were made by means of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) experiments for ondansetron, and by means of 1H-1H correlation spectroscopy (1H-1H COSY) and two-dimensional nuclear Overhauser effect spectroscopy (NOESY) experiments for two novel metabolites (M1 and M2) of ondansetron. These two metabolites were isolated for the first time from Mucor circinelloides.

Authors+Show Affiliations

Duan M
Laboratory of Drug Metabolism and Pharmacokinetics, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, People's Republic of China.
Huang H
No affiliation info available
Li X
No affiliation info available
Chen X
No affiliation info available
Zhong D
No affiliation info available

MeSH

Carbon IsotopesHydrogenMagnetic Resonance SpectroscopyMolecular StructureMucorOndansetronStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16835896

Citation

Duan, Mingyu, et al. "Assignments of 1H and 13C NMR Spectral Data for Ondansetron and Its Two Novel Metabolites, 1-hydroxy-ondansetron Diastereoisomers." Magnetic Resonance in Chemistry : MRC, vol. 44, no. 10, 2006, pp. 972-5.
Duan M, Huang H, Li X, et al. Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers. Magn Reson Chem. 2006;44(10):972-5.
Duan, M., Huang, H., Li, X., Chen, X., & Zhong, D. (2006). Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers. Magnetic Resonance in Chemistry : MRC, 44(10), 972-5.
Duan M, et al. Assignments of 1H and 13C NMR Spectral Data for Ondansetron and Its Two Novel Metabolites, 1-hydroxy-ondansetron Diastereoisomers. Magn Reson Chem. 2006;44(10):972-5. PubMed PMID: 16835896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomers. AU - Duan,Mingyu, AU - Huang,Haihua, AU - Li,Xinnan, AU - Chen,Xiaoyan, AU - Zhong,Dafang, PY - 2006/7/13/pubmed PY - 2007/9/6/medline PY - 2006/7/13/entrez SP - 972 EP - 5 JF - Magnetic resonance in chemistry : MRC JO - Magn Reson Chem VL - 44 IS - 10 N2 - Assignments of 1H and 13C NMR chemical shifts were made by means of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) experiments for ondansetron, and by means of 1H-1H correlation spectroscopy (1H-1H COSY) and two-dimensional nuclear Overhauser effect spectroscopy (NOESY) experiments for two novel metabolites (M1 and M2) of ondansetron. These two metabolites were isolated for the first time from Mucor circinelloides. SN - 0749-1581 UR - https://www.unboundmedicine.com/medline/citation/16835896/Assignments_of_1H_and_13C_NMR_spectral_data_for_ondansetron_and_its_two_novel_metabolites_1_hydroxy_ondansetron_diastereoisomers_ L2 - https://doi.org/10.1002/mrc.1876 DB - PRIME DP - Unbound Medicine ER -