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[Complete neuroleptic withdrawal in patients with schizophrenia with intense symptoms and resistant to treatment].
Encephale. 1991 Jul-Aug; 17(4):255-61.E

Abstract

We report 2 studies evaluating the effects of a complete and progressive neuroleptic withdrawal on the symptomatology of 2 groups of 10 young chronically ill schizophrenic inpatients. In a preliminary open study, we compare the psychiatric symptomatology during a 4-week-period before the beginning of withdrawal and during a similar period following the end of withdrawal. We observe the significative improvement of the blunted affect, the deterioration of an aspecific psychiatric symptomatology (including irritability, excitement, hostility) and the non-modification of the specific schizophrenic symptomatology (in its 3 main components: positive signs, negative signs, disorganization). The second study (a double blind one) reports the effects of a complete neuroleptic withdrawal maintained during a longer period (8 weeks): 1. The improvement of the blunted affect is transiently observed during the 2 first weeks after the end of withdrawal but not after this time. 2. The deterioration of the aspecific psychiatric symptomatology by opposition to the non-significative modification of the specific schizophrenic symptomatology is a fact confirmed by this second study. Even if we can not exclude that the influence of neuroleptic withdrawal on the specific psychotic symptoms may require a longer time frame than 8 weeks to detect, this dichotomic evolution raises the problem of the specific action of neuroleptics in this particular category of patients.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Centre de recherche Université Laval Robert-Giffard, Beauport, (Québec), Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Clinical Trial
English Abstract
Journal Article

Language

fre

PubMed ID

1683626

Citation

Wolf, M A., et al. "[Complete Neuroleptic Withdrawal in Patients With Schizophrenia With Intense Symptoms and Resistant to Treatment]." L'Encephale, vol. 17, no. 4, 1991, pp. 255-61.
Wolf MA, Bailly L, Diener JM, et al. [Complete neuroleptic withdrawal in patients with schizophrenia with intense symptoms and resistant to treatment]. Encephale. 1991;17(4):255-61.
Wolf, M. A., Bailly, L., Diener, J. M., Martinet, J. P., Peretti, S., & Garneau, Y. (1991). [Complete neuroleptic withdrawal in patients with schizophrenia with intense symptoms and resistant to treatment]. L'Encephale, 17(4), 255-61.
Wolf MA, et al. [Complete Neuroleptic Withdrawal in Patients With Schizophrenia With Intense Symptoms and Resistant to Treatment]. Encephale. 1991 Jul-Aug;17(4):255-61. PubMed PMID: 1683626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Complete neuroleptic withdrawal in patients with schizophrenia with intense symptoms and resistant to treatment]. AU - Wolf,M A, AU - Bailly,L, AU - Diener,J M, AU - Martinet,J P, AU - Peretti,S, AU - Garneau,Y, PY - 1991/7/1/pubmed PY - 1991/7/1/medline PY - 1991/7/1/entrez SP - 255 EP - 61 JF - L'Encephale JO - Encephale VL - 17 IS - 4 N2 - We report 2 studies evaluating the effects of a complete and progressive neuroleptic withdrawal on the symptomatology of 2 groups of 10 young chronically ill schizophrenic inpatients. In a preliminary open study, we compare the psychiatric symptomatology during a 4-week-period before the beginning of withdrawal and during a similar period following the end of withdrawal. We observe the significative improvement of the blunted affect, the deterioration of an aspecific psychiatric symptomatology (including irritability, excitement, hostility) and the non-modification of the specific schizophrenic symptomatology (in its 3 main components: positive signs, negative signs, disorganization). The second study (a double blind one) reports the effects of a complete neuroleptic withdrawal maintained during a longer period (8 weeks): 1. The improvement of the blunted affect is transiently observed during the 2 first weeks after the end of withdrawal but not after this time. 2. The deterioration of the aspecific psychiatric symptomatology by opposition to the non-significative modification of the specific schizophrenic symptomatology is a fact confirmed by this second study. Even if we can not exclude that the influence of neuroleptic withdrawal on the specific psychotic symptoms may require a longer time frame than 8 weeks to detect, this dichotomic evolution raises the problem of the specific action of neuroleptics in this particular category of patients.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0013-7006 UR - https://www.unboundmedicine.com/medline/citation/1683626/[Complete_neuroleptic_withdrawal_in_patients_with_schizophrenia_with_intense_symptoms_and_resistant_to_treatment]_ L2 - http://www.diseaseinfosearch.org/result/6442 DB - PRIME DP - Unbound Medicine ER -