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Heliconols A-C: antimicrobial hemiketals from the freshwater aquatic fungus Helicodendron giganteum.
Org Lett. 2006 Jul 20; 8(15):3191-4.OL

Abstract

[Structure: see text] Cultures of the freshwater aquatic fungus Helicodendron giganteum afforded three new compounds, heliconols A-C (1-3), that contain an unusual reduced furanocyclopentane unit. The structures of these metabolites were assigned by analysis of 1D and 2D NMR data. The absolute configuration of heliconol A (1) was assigned by single-crystal X-ray crystallographic analysis of its dibromobenzoate derivative. Heliconol A showed antifungal and antibacterial activities in disk diffusion assays.

Authors+Show Affiliations

Mudur SV
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Swenson DC
No affiliation info available
Gloer JB
No affiliation info available
Campbell J
No affiliation info available
Shearer CA
No affiliation info available

MeSH

Anti-Bacterial AgentsAntifungal AgentsAspergillus flavusBacillus subtilisCandida albicansFuransFusariumMicrobial Sensitivity TestsMitosporic FungiMolecular StructureStaphylococcus aureus

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16836363

Citation

Mudur, Sanjay V., et al. "Heliconols A-C: Antimicrobial Hemiketals From the Freshwater Aquatic Fungus Helicodendron Giganteum." Organic Letters, vol. 8, no. 15, 2006, pp. 3191-4.
Mudur SV, Swenson DC, Gloer JB, et al. Heliconols A-C: antimicrobial hemiketals from the freshwater aquatic fungus Helicodendron giganteum. Org Lett. 2006;8(15):3191-4.
Mudur, S. V., Swenson, D. C., Gloer, J. B., Campbell, J., & Shearer, C. A. (2006). Heliconols A-C: antimicrobial hemiketals from the freshwater aquatic fungus Helicodendron giganteum. Organic Letters, 8(15), 3191-4.
Mudur SV, et al. Heliconols A-C: Antimicrobial Hemiketals From the Freshwater Aquatic Fungus Helicodendron Giganteum. Org Lett. 2006 Jul 20;8(15):3191-4. PubMed PMID: 16836363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heliconols A-C: antimicrobial hemiketals from the freshwater aquatic fungus Helicodendron giganteum. AU - Mudur,Sanjay V, AU - Swenson,Dale C, AU - Gloer,James B, AU - Campbell,Jinx, AU - Shearer,Carol A, PY - 2006/7/14/pubmed PY - 2007/5/15/medline PY - 2006/7/14/entrez SP - 3191 EP - 4 JF - Organic letters JO - Org Lett VL - 8 IS - 15 N2 - [Structure: see text] Cultures of the freshwater aquatic fungus Helicodendron giganteum afforded three new compounds, heliconols A-C (1-3), that contain an unusual reduced furanocyclopentane unit. The structures of these metabolites were assigned by analysis of 1D and 2D NMR data. The absolute configuration of heliconol A (1) was assigned by single-crystal X-ray crystallographic analysis of its dibromobenzoate derivative. Heliconol A showed antifungal and antibacterial activities in disk diffusion assays. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/16836363/Heliconols_A_C:_antimicrobial_hemiketals_from_the_freshwater_aquatic_fungus_Helicodendron_giganteum_ DB - PRIME DP - Unbound Medicine ER -