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Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging.
Neurobiol Aging. 2007 Aug; 28(8):1187-94.NA

Abstract

Exposing young rats to particles of high-energy and charge (HZE particles) enhances indices of oxidative stress and inflammation and disrupts the functioning of the dopaminergic system and behaviors mediated by this system in a manner similar to that seen in aged animals. Previous research has shown that diets supplemented with 2% blueberry or strawberry extracts have the ability to retard and even reverse age-related deficits in behavior and signal transduction in rats, perhaps due to their antioxidant and anti-inflammatory properties. This study evaluated the efficacy of these diets on irradiation-induced deficits in these parameters by maintaining rats on these diets or a control diet for 8 weeks prior to being exposed to whole-body irradiation with 1.5 Gy of 1 GeV/n high-energy (56)Fe particles. Irradiation impaired performance in the Morris water maze and measures of dopamine release 1 month following radiation; these deficits were protected by the antioxidant diets. The strawberry diet offered better protection against spatial deficits in the maze because strawberry-fed animals were better able to retain place information (a hippocampally mediated behavior) compared to controls. The blueberry diet, on the other hand, seemed to improve reversal learning, a behavior more dependent on intact striatal function. These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions.

Authors+Show Affiliations

USDA-ARS, Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, United States. barbara.hale@tufts.edu <barbara.hale@tufts.edu>No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16837106

Citation

Shukitt-Hale, Barbara, et al. "Beneficial Effects of Fruit Extracts On Neuronal Function and Behavior in a Rodent Model of Accelerated Aging." Neurobiology of Aging, vol. 28, no. 8, 2007, pp. 1187-94.
Shukitt-Hale B, Carey AN, Jenkins D, et al. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging. 2007;28(8):1187-94.
Shukitt-Hale, B., Carey, A. N., Jenkins, D., Rabin, B. M., & Joseph, J. A. (2007). Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiology of Aging, 28(8), 1187-94.
Shukitt-Hale B, et al. Beneficial Effects of Fruit Extracts On Neuronal Function and Behavior in a Rodent Model of Accelerated Aging. Neurobiol Aging. 2007;28(8):1187-94. PubMed PMID: 16837106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. AU - Shukitt-Hale,Barbara, AU - Carey,Amanda N, AU - Jenkins,Daniel, AU - Rabin,Bernard M, AU - Joseph,James A, Y1 - 2006/07/11/ PY - 2005/12/02/received PY - 2006/05/09/revised PY - 2006/05/30/accepted PY - 2006/7/14/pubmed PY - 2007/7/11/medline PY - 2006/7/14/entrez SP - 1187 EP - 94 JF - Neurobiology of aging JO - Neurobiol Aging VL - 28 IS - 8 N2 - Exposing young rats to particles of high-energy and charge (HZE particles) enhances indices of oxidative stress and inflammation and disrupts the functioning of the dopaminergic system and behaviors mediated by this system in a manner similar to that seen in aged animals. Previous research has shown that diets supplemented with 2% blueberry or strawberry extracts have the ability to retard and even reverse age-related deficits in behavior and signal transduction in rats, perhaps due to their antioxidant and anti-inflammatory properties. This study evaluated the efficacy of these diets on irradiation-induced deficits in these parameters by maintaining rats on these diets or a control diet for 8 weeks prior to being exposed to whole-body irradiation with 1.5 Gy of 1 GeV/n high-energy (56)Fe particles. Irradiation impaired performance in the Morris water maze and measures of dopamine release 1 month following radiation; these deficits were protected by the antioxidant diets. The strawberry diet offered better protection against spatial deficits in the maze because strawberry-fed animals were better able to retain place information (a hippocampally mediated behavior) compared to controls. The blueberry diet, on the other hand, seemed to improve reversal learning, a behavior more dependent on intact striatal function. These data suggest that (56)Fe particle irradiation causes deficits in behavior and signaling in rats which were ameliorated by an antioxidant diet and that the polyphenols in these fruits might be acting in different brain regions. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/16837106/Beneficial_effects_of_fruit_extracts_on_neuronal_function_and_behavior_in_a_rodent_model_of_accelerated_aging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00192-8 DB - PRIME DP - Unbound Medicine ER -