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Human African trypanosomiasis: connecting parasite and host genetics.
Trends Parasitol. 2006 Sep; 22(9):405-9.TP

Abstract

In West and Central Africa, the protozoan parasite Trypanosoma brucei (T. b.) gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence.

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Authors+Show Affiliations

Garcia A
Institut de Recherche pour le Développement, Unité de Recherche 010, Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75270 Paris, France. andre.garcia@ird.fr
Courtin D
No affiliation info available
Solano P
No affiliation info available
Koffi M
No affiliation info available
Jamonneau V
No affiliation info available

MeSH

AfricaAnimalsEndemic DiseasesGenetic VariationHost-Parasite InteractionsHumansImmunity, InnateTrypanosoma brucei gambienseTrypanosoma brucei rhodesienseTrypanosomiasis, African

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16837245

Citation

Garcia, André, et al. "Human African Trypanosomiasis: Connecting Parasite and Host Genetics." Trends in Parasitology, vol. 22, no. 9, 2006, pp. 405-9.
Garcia A, Courtin D, Solano P, et al. Human African trypanosomiasis: connecting parasite and host genetics. Trends Parasitol. 2006;22(9):405-9.
Garcia, A., Courtin, D., Solano, P., Koffi, M., & Jamonneau, V. (2006). Human African trypanosomiasis: connecting parasite and host genetics. Trends in Parasitology, 22(9), 405-9.
Garcia A, et al. Human African Trypanosomiasis: Connecting Parasite and Host Genetics. Trends Parasitol. 2006;22(9):405-9. PubMed PMID: 16837245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human African trypanosomiasis: connecting parasite and host genetics. AU - Garcia,André, AU - Courtin,David, AU - Solano,Philippe, AU - Koffi,Mathurin, AU - Jamonneau,Vincent, Y1 - 2006/07/11/ PY - 2006/01/27/received PY - 2006/06/07/revised PY - 2006/06/28/accepted PY - 2006/7/14/pubmed PY - 2006/10/17/medline PY - 2006/7/14/entrez SP - 405 EP - 9 JF - Trends in parasitology JO - Trends Parasitol VL - 22 IS - 9 N2 - In West and Central Africa, the protozoan parasite Trypanosoma brucei (T. b.) gambiense causes a chronic form of Human African trypanosomiasis (HAT) that might last several years, whereas T. b. rhodesiense refers to an acute form in East Africa that lasts weeks to months. Without treatment, both forms can cause death. Diagnosis relies on detecting parasites in blood, lymph or cerebrospinal fluid. HAT was no longer considered a public health problem in the 1960s, but it returned to alarming levels in the 1990s. After intensifying case detection and treatment, WHO recently declared the situation is under control. However, research based on host and trypanosome interactions should be encouraged to help develop innovative tools for HAT diagnosis and treatment to prevent re-emergence. SN - 1471-4922 UR - https://www.unboundmedicine.com/medline/citation/16837245/Human_African_trypanosomiasis:_connecting_parasite_and_host_genetics_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4922(06)00172-3 DB - PRIME DP - Unbound Medicine ER -