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Reduced semantic fluency as an additional screening tool for subjects with questionable dementia.
Dement Geriatr Cogn Disord. 2006; 22(2):159-64.DG

Abstract

BACKGROUND

Subjective memory complaints in subjects with mild cognitive impairment may represent a genuine decline in episodic memory. This paper evaluates the neuropsychological correlates of the semantic fluency test in subjects with questionable dementia (QD).

METHODS

A total of 331 Chinese subjects (118 normal controls, NC, 150 with QD and 63 with mild Alzheimer's disease, AD) were assessed with the Category Verbal Fluency Test (CVFT), the AD Assessment Scale-cognitive subscale (ADAS-Cog), and digit and verbal span tests. CVFT performance was evaluated in each Clinical Dementia Rating (CDR) group. The total number of exemplars, the subcategory and the category size generated were evaluated. Neuropsychological correlates of CVFT scores were computed.

RESULTS

Significant differences in CVFT performance were found between the different CDR groups. The subjects with QD had intermediate scores compared to the NC and AD subjects (1-way ANOVA, p < 0.001, post-hoc Bonferroni comparisons). In NC the CVFT scores were significantly associated with ADAS-Cog total, and immediate and delayed recall scores (partial correlations controlled for age and education, p < 0.005). In the QD group the CVFT scores were correlated with ADAS-Cog total, and immediate recall and object naming scores (partial correlation controlled for age and education, p < 0.005). Regression analysis revealed that age and delayed recall were significant predictors of CVFT performance in NCs. In the QD group, age, ADAS-Cog immediate recall and object naming scores predicted the CVFT performance.

CONCLUSIONS

The CVFT was impaired in the subjects with QD. Apart from episodic memory, semantic memory deficits also occur early in AD. The different cognitive predictors of CVFT scores in the NC and QD groups suggest that the test is associated with specific psychological functions at different stages of cognitive impairment.

Authors+Show Affiliations

Department of Psychiatry, Chinese University of Hong Kong, SAR, China. cwlam@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16837791

Citation

Lam, Linda Chiu Wa, et al. "Reduced Semantic Fluency as an Additional Screening Tool for Subjects With Questionable Dementia." Dementia and Geriatric Cognitive Disorders, vol. 22, no. 2, 2006, pp. 159-64.
Lam LC, Ho P, Lui VW, et al. Reduced semantic fluency as an additional screening tool for subjects with questionable dementia. Dement Geriatr Cogn Disord. 2006;22(2):159-64.
Lam, L. C., Ho, P., Lui, V. W., & Tam, C. W. (2006). Reduced semantic fluency as an additional screening tool for subjects with questionable dementia. Dementia and Geriatric Cognitive Disorders, 22(2), 159-64.
Lam LC, et al. Reduced Semantic Fluency as an Additional Screening Tool for Subjects With Questionable Dementia. Dement Geriatr Cogn Disord. 2006;22(2):159-64. PubMed PMID: 16837791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced semantic fluency as an additional screening tool for subjects with questionable dementia. AU - Lam,Linda Chiu Wa, AU - Ho,Patty, AU - Lui,Victor Wing Cheong, AU - Tam,Cindy Woon Chi, Y1 - 2006/07/12/ PY - 2006/02/23/accepted PY - 2006/7/14/pubmed PY - 2006/12/9/medline PY - 2006/7/14/entrez SP - 159 EP - 64 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 22 IS - 2 N2 - BACKGROUND: Subjective memory complaints in subjects with mild cognitive impairment may represent a genuine decline in episodic memory. This paper evaluates the neuropsychological correlates of the semantic fluency test in subjects with questionable dementia (QD). METHODS: A total of 331 Chinese subjects (118 normal controls, NC, 150 with QD and 63 with mild Alzheimer's disease, AD) were assessed with the Category Verbal Fluency Test (CVFT), the AD Assessment Scale-cognitive subscale (ADAS-Cog), and digit and verbal span tests. CVFT performance was evaluated in each Clinical Dementia Rating (CDR) group. The total number of exemplars, the subcategory and the category size generated were evaluated. Neuropsychological correlates of CVFT scores were computed. RESULTS: Significant differences in CVFT performance were found between the different CDR groups. The subjects with QD had intermediate scores compared to the NC and AD subjects (1-way ANOVA, p < 0.001, post-hoc Bonferroni comparisons). In NC the CVFT scores were significantly associated with ADAS-Cog total, and immediate and delayed recall scores (partial correlations controlled for age and education, p < 0.005). In the QD group the CVFT scores were correlated with ADAS-Cog total, and immediate recall and object naming scores (partial correlation controlled for age and education, p < 0.005). Regression analysis revealed that age and delayed recall were significant predictors of CVFT performance in NCs. In the QD group, age, ADAS-Cog immediate recall and object naming scores predicted the CVFT performance. CONCLUSIONS: The CVFT was impaired in the subjects with QD. Apart from episodic memory, semantic memory deficits also occur early in AD. The different cognitive predictors of CVFT scores in the NC and QD groups suggest that the test is associated with specific psychological functions at different stages of cognitive impairment. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/16837791/Reduced_semantic_fluency_as_an_additional_screening_tool_for_subjects_with_questionable_dementia_ L2 - https://www.karger.com?DOI=10.1159/000094543 DB - PRIME DP - Unbound Medicine ER -