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Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease.
Neuroreport. 2006 Jul 31; 17(11):1215-8.N

Abstract

We carried out an investigation to identify neuromelanin-containing noradrenergic and dopaminergic neurons in the locus ceruleus and substantia nigra pars compacta of healthy volunteers and patients with Parkinson's disease using a newly developed magnetic resonance imaging technique that can demonstrate neuromelanin-related contrast. The high-resolution neuromelanin images obtained by a 3-T scanner revealed high signal areas in the brain stem and these corresponded well with the location of the locus ceruleus and substantia nigra pars compacta in gross specimens. In Parkinson's disease patients, the signal intensity in the locus ceruleus and substantia nigra pars compacta was greatly reduced, suggesting depletion of neuromelanin-containing neurons. We conclude that neuromelanin magnetic resonance imaging can be used for direct visualization of the locus ceruleus and substantia nigra pars compacta, and may help in detecting pathological changes in Parkinson's disease and related disorders.

Authors+Show Affiliations

Department of Radiology, Iwate Medical University, Morioka, Japan. masasaki@iwate-med.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16837857

Citation

Sasaki, Makoto, et al. "Neuromelanin Magnetic Resonance Imaging of Locus Ceruleus and Substantia Nigra in Parkinson's Disease." Neuroreport, vol. 17, no. 11, 2006, pp. 1215-8.
Sasaki M, Shibata E, Tohyama K, et al. Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease. Neuroreport. 2006;17(11):1215-8.
Sasaki, M., Shibata, E., Tohyama, K., Takahashi, J., Otsuka, K., Tsuchiya, K., Takahashi, S., Ehara, S., Terayama, Y., & Sakai, A. (2006). Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease. Neuroreport, 17(11), 1215-8.
Sasaki M, et al. Neuromelanin Magnetic Resonance Imaging of Locus Ceruleus and Substantia Nigra in Parkinson's Disease. Neuroreport. 2006 Jul 31;17(11):1215-8. PubMed PMID: 16837857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuromelanin magnetic resonance imaging of locus ceruleus and substantia nigra in Parkinson's disease. AU - Sasaki,Makoto, AU - Shibata,Eri, AU - Tohyama,Koujiro, AU - Takahashi,Junko, AU - Otsuka,Kotaro, AU - Tsuchiya,Kuniaki, AU - Takahashi,Satoshi, AU - Ehara,Shigeru, AU - Terayama,Yasuo, AU - Sakai,Akio, PY - 2006/7/14/pubmed PY - 2006/9/16/medline PY - 2006/7/14/entrez SP - 1215 EP - 8 JF - Neuroreport JO - Neuroreport VL - 17 IS - 11 N2 - We carried out an investigation to identify neuromelanin-containing noradrenergic and dopaminergic neurons in the locus ceruleus and substantia nigra pars compacta of healthy volunteers and patients with Parkinson's disease using a newly developed magnetic resonance imaging technique that can demonstrate neuromelanin-related contrast. The high-resolution neuromelanin images obtained by a 3-T scanner revealed high signal areas in the brain stem and these corresponded well with the location of the locus ceruleus and substantia nigra pars compacta in gross specimens. In Parkinson's disease patients, the signal intensity in the locus ceruleus and substantia nigra pars compacta was greatly reduced, suggesting depletion of neuromelanin-containing neurons. We conclude that neuromelanin magnetic resonance imaging can be used for direct visualization of the locus ceruleus and substantia nigra pars compacta, and may help in detecting pathological changes in Parkinson's disease and related disorders. SN - 0959-4965 UR - https://www.unboundmedicine.com/medline/citation/16837857/Neuromelanin_magnetic_resonance_imaging_of_locus_ceruleus_and_substantia_nigra_in_Parkinson's_disease_ L2 - https://doi.org/10.1097/01.wnr.0000227984.84927.a7 DB - PRIME DP - Unbound Medicine ER -