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Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy.
Br J Surg. 2006 Oct; 93(10):1226-31.BJ

Abstract

BACKGROUND

The interferon-gamma-inducible chemokine CXCL10 is highly expressed in infiltrating inflammatory cells, and in thyrocytes in patients with Graves' disease. The aim of this study was to measure serum levels of CXCL10 in relation to thyroid function and treatment.

METHODS

Serum levels of CXCL10 were measured in 22 patients with Graves' disease when hyperthyroid, when euthyroid under methimazole therapy, and 3 days after near-total thyroidectomy. They were compared with levels in three groups of age- and sex-matched controls: 44 subjects with no thyroid disorder, 44 patients with euthyroid autoimmune thyroiditis and 20 with toxic nodular goitre.

RESULTS

Basal serum levels of CXCL10 in patients with Graves' disease were higher than levels in patients with toxic nodular goitre or no thyroid disorder, and similar to levels in patients with autoimmune thyroiditis (mean(s.d.) 167(121), 100(24), 78(46) and 142(107) pg/ml respectively; P < 0.010). Among patients with Graves' disease, serum levels of CXCL10 were significantly higher in those aged over 50 years (P = 0.010), with a hypoechoic pattern at thyroid ultrasonography (P < 0.001) or with hypervascularity (P = 0.001). CXCL10 levels in patients with Graves' disease decreased significantly when euthyroidism was achieved by methimazole therapy (P < 0.010), and a further decrease was observed after thyroidectomy (P < 0.010).

CONCLUSION

Serum levels of CXCL10 are higher in newly diagnosed hyperthyroid patients with Graves' disease than in those with toxic nodular goitre, and decrease when euthyroidism is achieved with antithyroid therapy. This high level may be related to the active inflammatory phase of Graves' disease. A further reduction of CXCL10 levels after thyroidectomy indicates that it is produced mainly in the thyroid in patients with autoimmune thyroid disease.

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Authors+Show Affiliations

Antonelli A
Metabolism Unit, Department of Internal Medicine, University of Pisa, Pisa, Italy. a.antonelli@med.unipi.it
Fallahi P
No affiliation info available
Rotondi M
No affiliation info available
Ferrari SM
No affiliation info available
Serio M
No affiliation info available
Miccoli P
No affiliation info available

MeSH

Antithyroid AgentsCase-Control StudiesChemokine CXCL10Chemokines, CXCFemaleGraves DiseaseHumansMaleMethimazoleMiddle AgedRetrospective StudiesThyroidectomyTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16838393

Citation

Antonelli, A, et al. "Serum Levels of the Interferon-gamma-inducible Alpha Chemokine CXCL10 in Patients With Active Graves' Disease, and Modulation By Methimazole Therapy and Thyroidectomy." The British Journal of Surgery, vol. 93, no. 10, 2006, pp. 1226-31.
Antonelli A, Fallahi P, Rotondi M, et al. Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy. Br J Surg. 2006;93(10):1226-31.
Antonelli, A., Fallahi, P., Rotondi, M., Ferrari, S. M., Serio, M., & Miccoli, P. (2006). Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy. The British Journal of Surgery, 93(10), 1226-31.
Antonelli A, et al. Serum Levels of the Interferon-gamma-inducible Alpha Chemokine CXCL10 in Patients With Active Graves' Disease, and Modulation By Methimazole Therapy and Thyroidectomy. Br J Surg. 2006;93(10):1226-31. PubMed PMID: 16838393.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of the interferon-gamma-inducible alpha chemokine CXCL10 in patients with active Graves' disease, and modulation by methimazole therapy and thyroidectomy. AU - Antonelli,A, AU - Fallahi,P, AU - Rotondi,M, AU - Ferrari,S M, AU - Serio,M, AU - Miccoli,P, PY - 2006/7/14/pubmed PY - 2006/11/2/medline PY - 2006/7/14/entrez SP - 1226 EP - 31 JF - The British journal of surgery JO - Br J Surg VL - 93 IS - 10 N2 - BACKGROUND: The interferon-gamma-inducible chemokine CXCL10 is highly expressed in infiltrating inflammatory cells, and in thyrocytes in patients with Graves' disease. The aim of this study was to measure serum levels of CXCL10 in relation to thyroid function and treatment. METHODS: Serum levels of CXCL10 were measured in 22 patients with Graves' disease when hyperthyroid, when euthyroid under methimazole therapy, and 3 days after near-total thyroidectomy. They were compared with levels in three groups of age- and sex-matched controls: 44 subjects with no thyroid disorder, 44 patients with euthyroid autoimmune thyroiditis and 20 with toxic nodular goitre. RESULTS: Basal serum levels of CXCL10 in patients with Graves' disease were higher than levels in patients with toxic nodular goitre or no thyroid disorder, and similar to levels in patients with autoimmune thyroiditis (mean(s.d.) 167(121), 100(24), 78(46) and 142(107) pg/ml respectively; P < 0.010). Among patients with Graves' disease, serum levels of CXCL10 were significantly higher in those aged over 50 years (P = 0.010), with a hypoechoic pattern at thyroid ultrasonography (P < 0.001) or with hypervascularity (P = 0.001). CXCL10 levels in patients with Graves' disease decreased significantly when euthyroidism was achieved by methimazole therapy (P < 0.010), and a further decrease was observed after thyroidectomy (P < 0.010). CONCLUSION: Serum levels of CXCL10 are higher in newly diagnosed hyperthyroid patients with Graves' disease than in those with toxic nodular goitre, and decrease when euthyroidism is achieved with antithyroid therapy. This high level may be related to the active inflammatory phase of Graves' disease. A further reduction of CXCL10 levels after thyroidectomy indicates that it is produced mainly in the thyroid in patients with autoimmune thyroid disease. SN - 0007-1323 UR - https://www.unboundmedicine.com/medline/citation/16838393/Serum_levels_of_the_interferon_gamma_inducible_alpha_chemokine_CXCL10_in_patients_with_active_Graves'_disease_and_modulation_by_methimazole_therapy_and_thyroidectomy_ L2 - https://doi.org/10.1002/bjs.5401 DB - PRIME DP - Unbound Medicine ER -