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Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea.
Metabolism. 2006 Aug; 55(8):1076-82.M

Abstract

Premenopausal women with polycystic ovary syndrome (PCOS) are at a much higher risk for excessive daytime sleepiness, fatigue, and insulin resistance than control women. Elevated levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) are presumably part of the pathogenesis of these clinical manifestations. Forty-two obese women with PCOS, 17 body mass index-comparable obese controls, and 15 normal-weight controls free from apnea participated in the study that included one 8-hour nighttime polysomnography, single morning cytokine plasma concentrations, and insulin resistance indices. Women with PCOS exhibited higher plasma concentrations of IL-6 than obese controls, who had intermediate values, or normal-weight controls, who had the lowest values (4.75 +/- 0.5 vs 3.65 +/- 0.4 vs 1.84 +/- 0.3 pg/mL, P < .01). Tumor necrosis factor alpha values were higher in PCOS and obese controls compared with normal-weight controls, but the difference was not statistically significant (4.05 +/- 0.3 vs 3.79 +/- 0.2 vs 3.14 +/- 0.2 pg/mL, P = .103). Based on backward regression analysis, IL-6 levels had a stronger association with the PCOS group than with the obese group, and the sleep or hypoxia variables did not make a significant contribution to either IL-6 or TNF-alpha. Both IL-6 and TNF-alpha correlated positively with body mass index (P < .01) in obese controls but not in women with PCOS. Furthermore, within the PCOS group, IL-6 and TNF-alpha correlated more strongly with indices of insulin resistance than obesity. We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance.

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Authors+Show Affiliations

Vgontzas AN
Sleep Research and Treatment Center, Department of Psychiatry H073, Penn State University College of Medicine, Hershey, PA 17033, USA. axv3@psu.edu
Trakada G
No affiliation info available
Bixler EO
No affiliation info available
Lin HM
No affiliation info available
Pejovic S
No affiliation info available
Zoumakis E
No affiliation info available
Chrousos GP
No affiliation info available
Legro RS
No affiliation info available

MeSH

AdultBlood GlucoseBody Mass IndexBody WeightCytokinesFemaleHemodynamicsHumansInsulinInsulin ResistanceInterleukin-6ObesityPolycystic Ovary SyndromePolysomnographyRespiratory Function TestsSleep Apnea SyndromesTestosteroneTumor Necrosis Factor-alpha

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16839844

Citation

Vgontzas, Alexandros N., et al. "Plasma Interleukin 6 Levels Are Elevated in Polycystic Ovary Syndrome Independently of Obesity or Sleep Apnea." Metabolism: Clinical and Experimental, vol. 55, no. 8, 2006, pp. 1076-82.
Vgontzas AN, Trakada G, Bixler EO, et al. Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. Metabolism. 2006;55(8):1076-82.
Vgontzas, A. N., Trakada, G., Bixler, E. O., Lin, H. M., Pejovic, S., Zoumakis, E., Chrousos, G. P., & Legro, R. S. (2006). Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. Metabolism: Clinical and Experimental, 55(8), 1076-82.
Vgontzas AN, et al. Plasma Interleukin 6 Levels Are Elevated in Polycystic Ovary Syndrome Independently of Obesity or Sleep Apnea. Metabolism. 2006;55(8):1076-82. PubMed PMID: 16839844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea. AU - Vgontzas,Alexandros N, AU - Trakada,Georgia, AU - Bixler,Edward O, AU - Lin,Hung-Mo, AU - Pejovic,Slobodanka, AU - Zoumakis,Emmanuel, AU - Chrousos,George P, AU - Legro,Richard S, PY - 2004/12/10/received PY - 2006/04/07/accepted PY - 2006/7/15/pubmed PY - 2006/8/19/medline PY - 2006/7/15/entrez SP - 1076 EP - 82 JF - Metabolism: clinical and experimental JO - Metabolism VL - 55 IS - 8 N2 - Premenopausal women with polycystic ovary syndrome (PCOS) are at a much higher risk for excessive daytime sleepiness, fatigue, and insulin resistance than control women. Elevated levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) are presumably part of the pathogenesis of these clinical manifestations. Forty-two obese women with PCOS, 17 body mass index-comparable obese controls, and 15 normal-weight controls free from apnea participated in the study that included one 8-hour nighttime polysomnography, single morning cytokine plasma concentrations, and insulin resistance indices. Women with PCOS exhibited higher plasma concentrations of IL-6 than obese controls, who had intermediate values, or normal-weight controls, who had the lowest values (4.75 +/- 0.5 vs 3.65 +/- 0.4 vs 1.84 +/- 0.3 pg/mL, P < .01). Tumor necrosis factor alpha values were higher in PCOS and obese controls compared with normal-weight controls, but the difference was not statistically significant (4.05 +/- 0.3 vs 3.79 +/- 0.2 vs 3.14 +/- 0.2 pg/mL, P = .103). Based on backward regression analysis, IL-6 levels had a stronger association with the PCOS group than with the obese group, and the sleep or hypoxia variables did not make a significant contribution to either IL-6 or TNF-alpha. Both IL-6 and TNF-alpha correlated positively with body mass index (P < .01) in obese controls but not in women with PCOS. Furthermore, within the PCOS group, IL-6 and TNF-alpha correlated more strongly with indices of insulin resistance than obesity. We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/16839844/Plasma_interleukin_6_levels_are_elevated_in_polycystic_ovary_syndrome_independently_of_obesity_or_sleep_apnea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(06)00135-1 DB - PRIME DP - Unbound Medicine ER -