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Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension.
Endothelium. 2006 May-Jun; 13(3):227-31.E

Abstract

There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p < .0001). Significant increase was also observed for MMP-9 level and activity (p < .0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism.

Authors+Show Affiliations

Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. giuderosa@tin.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16840178

Citation

Derosa, Giuseppe, et al. "Matrix Metalloproteinase-2, -9, and Tissue Inhibitor of Metalloproteinase-1 in Patients With Hypertension." Endothelium : Journal of Endothelial Cell Research, vol. 13, no. 3, 2006, pp. 227-31.
Derosa G, D'Angelo A, Ciccarelli L, et al. Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Endothelium. 2006;13(3):227-31.
Derosa, G., D'Angelo, A., Ciccarelli, L., Piccinni, M. N., Pricolo, F., Salvadeo, S., Montagna, L., Gravina, A., Ferrari, I., Galli, S., Paniga, S., Tinelli, C., & Cicero, A. F. (2006). Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. Endothelium : Journal of Endothelial Cell Research, 13(3), 227-31.
Derosa G, et al. Matrix Metalloproteinase-2, -9, and Tissue Inhibitor of Metalloproteinase-1 in Patients With Hypertension. Endothelium. 2006 May-Jun;13(3):227-31. PubMed PMID: 16840178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix metalloproteinase-2, -9, and tissue inhibitor of metalloproteinase-1 in patients with hypertension. AU - Derosa,Giuseppe, AU - D'Angelo,Angela, AU - Ciccarelli,Leonardina, AU - Piccinni,Mario N, AU - Pricolo,Fabio, AU - Salvadeo,Sibilla, AU - Montagna,Lorenza, AU - Gravina,Alessia, AU - Ferrari,Ilaria, AU - Galli,Simona, AU - Paniga,Sonia, AU - Tinelli,Carmine, AU - Cicero,Arrigo F G, PY - 2006/7/15/pubmed PY - 2006/9/13/medline PY - 2006/7/15/entrez SP - 227 EP - 31 JF - Endothelium : journal of endothelial cell research JO - Endothelium VL - 13 IS - 3 N2 - There are conflicting data in the literature regarding the expression pattern of the vascular matrix metalloproteinase (MMP) system and their inhibitors (TIMPs) in human hypertension. The authors hypothesized that MMP-2, MMP-9, and TIMP-1 would be abnormal in hypertension, reflecting alterations in extracellular matrix (ECM) turnover. The authors measured plasma levels and activities of MMP-2, MMP-9, and TIMP-1 in 44 hypertensive patients and 44 controls. MMP-2 levels and activity were significantly higher in hypertensive group (p < .0001). Significant increase was also observed for MMP-9 level and activity (p < .0001) and for TIMP-1 (p < .0001) in hypertensive patients. Plasma levels and activities of MMP-2, MMP-9, and TIMP-1 are increased in hypertensive patients, which may reflect abnormal ECM metabolism. SN - 1062-3329 UR - https://www.unboundmedicine.com/medline/citation/16840178/Matrix_metalloproteinase_2__9_and_tissue_inhibitor_of_metalloproteinase_1_in_patients_with_hypertension_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -