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Prevalence and genetic diversity of coronaviruses in bats from China.
J Virol. 2006 Aug; 80(15):7481-90.JV

Abstract

Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses showed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses.

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Authors+Show Affiliations

Tang XC
State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China.
Zhang JX
No affiliation info available
Zhang SY
No affiliation info available
Wang P
No affiliation info available
Fan XH
No affiliation info available
Li LF
No affiliation info available
Li G
No affiliation info available
Dong BQ
No affiliation info available
Liu W
No affiliation info available
Cheung CL
No affiliation info available
Xu KM
No affiliation info available
Song WJ
No affiliation info available
Vijaykrishna D
No affiliation info available
Poon LL
No affiliation info available
Peiris JS
No affiliation info available
Smith GJ
No affiliation info available
Chen H
No affiliation info available
Guan Y
No affiliation info available

MeSH

AnimalsChinaChiropteraCoronavirusEvolution, MolecularGenetic VariationGenome, ViralMolecular Sequence DataPhylogenyPrevalenceRNA, ViralSequence Analysis, DNAViral Proteins

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16840328

Citation

Tang, X C., et al. "Prevalence and Genetic Diversity of Coronaviruses in Bats From China." Journal of Virology, vol. 80, no. 15, 2006, pp. 7481-90.
Tang XC, Zhang JX, Zhang SY, et al. Prevalence and genetic diversity of coronaviruses in bats from China. J Virol. 2006;80(15):7481-90.
Tang, X. C., Zhang, J. X., Zhang, S. Y., Wang, P., Fan, X. H., Li, L. F., Li, G., Dong, B. Q., Liu, W., Cheung, C. L., Xu, K. M., Song, W. J., Vijaykrishna, D., Poon, L. L., Peiris, J. S., Smith, G. J., Chen, H., & Guan, Y. (2006). Prevalence and genetic diversity of coronaviruses in bats from China. Journal of Virology, 80(15), 7481-90.
Tang XC, et al. Prevalence and Genetic Diversity of Coronaviruses in Bats From China. J Virol. 2006;80(15):7481-90. PubMed PMID: 16840328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and genetic diversity of coronaviruses in bats from China. AU - Tang,X C, AU - Zhang,J X, AU - Zhang,S Y, AU - Wang,P, AU - Fan,X H, AU - Li,L F, AU - Li,G, AU - Dong,B Q, AU - Liu,W, AU - Cheung,C L, AU - Xu,K M, AU - Song,W J, AU - Vijaykrishna,D, AU - Poon,L L M, AU - Peiris,J S M, AU - Smith,G J D, AU - Chen,H, AU - Guan,Y, PY - 2006/7/15/pubmed PY - 2006/8/19/medline PY - 2006/7/15/entrez SP - 7481 EP - 90 JF - Journal of virology JO - J Virol VL - 80 IS - 15 N2 - Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. The interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. The outbreak of severe acute respiratory syndrome (SARS) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. In this study, we sampled bat populations in 15 provinces of China and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. Full genomes of four coronavirues from bats were sequenced and analyzed. Phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative RNA-dependent RNA polymerase and RNA helicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all SARS and SARS-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). Further genetic analyses showed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. Thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses. SN - 0022-538X UR - https://www.unboundmedicine.com/medline/citation/16840328/Prevalence_and_genetic_diversity_of_coronaviruses_in_bats_from_China_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=16840328 DB - PRIME DP - Unbound Medicine ER -