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[Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease].
Rev Neurol (Paris). 2006 Jun; 162(6-7):691-702.RN

Abstract

L-dopa treatment of Parkinson's disease is complicated in the long term by the appearance of dyskinesia. Hypersensitivity of D1 dopamine receptor has been suggested to play a role in these delayed adverse effects. Hypersensitivity of dopamine D1 receptor in Parkinson's disease can be accounted for by increased levels of Galphaolf, the stimulatory G protein which couples D1 receptor to adenylyl cyclase in the striatum. We here discuss the possible role of D1 receptor signal transduction in the genesis of L-dopa-induced dyskinesia in the light of Galphaolf regulation.

Links

Publisher Full Text
linkinghub.elsevier.com
em-consulte.com

Authors+Show Affiliations

Corvol JC
Fédération des Maladies du Système Nerveux, Hôpital de la Salpêtrière, Paris. Jean.Christophe.corvol@psl.ap-hop-paris.fr
Girault JA
No affiliation info available
Hervé D
No affiliation info available

MeSH

Antiparkinson AgentsCorpus StriatumCyclic AMPDyskinesia, Drug-InducedGTP-Binding ProteinsHumansLevodopaParkinson DiseaseReceptors, Dopamine D1Receptors, Dopamine D2

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

16840977

Citation

Corvol, J-C, et al. "[Role and Regulation of Dopamine D1 Receptors in the Striatum: Implications for the Genesis of Dyskinesia in Parkinson's Disease]." Revue Neurologique, vol. 162, no. 6-7, 2006, pp. 691-702.
Corvol JC, Girault JA, Hervé D. [Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]. Rev Neurol (Paris). 2006;162(6-7):691-702.
Corvol, J. C., Girault, J. A., & Hervé, D. (2006). [Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]. Revue Neurologique, 162(6-7), 691-702.
Corvol JC, Girault JA, Hervé D. [Role and Regulation of Dopamine D1 Receptors in the Striatum: Implications for the Genesis of Dyskinesia in Parkinson's Disease]. Rev Neurol (Paris). 2006;162(6-7):691-702. PubMed PMID: 16840977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Role and regulation of dopamine D1 receptors in the striatum: implications for the genesis of dyskinesia in Parkinson's disease]. AU - Corvol,J-C, AU - Girault,J-A, AU - Hervé,D, PY - 2006/7/15/pubmed PY - 2006/11/10/medline PY - 2006/7/15/entrez SP - 691 EP - 702 JF - Revue neurologique JO - Rev Neurol (Paris) VL - 162 IS - 6-7 N2 - L-dopa treatment of Parkinson's disease is complicated in the long term by the appearance of dyskinesia. Hypersensitivity of D1 dopamine receptor has been suggested to play a role in these delayed adverse effects. Hypersensitivity of dopamine D1 receptor in Parkinson's disease can be accounted for by increased levels of Galphaolf, the stimulatory G protein which couples D1 receptor to adenylyl cyclase in the striatum. We here discuss the possible role of D1 receptor signal transduction in the genesis of L-dopa-induced dyskinesia in the light of Galphaolf regulation. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/16840977/[Role_and_regulation_of_dopamine_D1_receptors_in_the_striatum:_implications_for_the_genesis_of_dyskinesia_in_Parkinson's_disease]_ L2 - https://linkinghub.elsevier.com/retrieve/pii/MDOI-RN-06-2006-162-6-7-0035-3787-101019-200601067 DB - PRIME DP - Unbound Medicine ER -