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Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study.
Cancer Causes Control. 2006 Sep; 17(7):957-69.CC

Abstract

Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.

Authors+Show Affiliations

Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany. boeing@mail.dife.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16841263

Citation

Boeing, Heiner, et al. "Intake of Fruits and Vegetables and Risk of Cancer of the Upper Aero-digestive Tract: the Prospective EPIC-study." Cancer Causes & Control : CCC, vol. 17, no. 7, 2006, pp. 957-69.
Boeing H, Dietrich T, Hoffmann K, et al. Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study. Cancer Causes Control. 2006;17(7):957-69.
Boeing, H., Dietrich, T., Hoffmann, K., Pischon, T., Ferrari, P., Lahmann, P. H., Boutron-Ruault, M. C., Clavel-Chapelon, F., Allen, N., Key, T., Skeie, G., Lund, E., Olsen, A., Tjonneland, A., Overvad, K., Jensen, M. K., Rohrmann, S., Linseisen, J., Trichopoulou, A., ... Riboli, E. (2006). Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study. Cancer Causes & Control : CCC, 17(7), 957-69.
Boeing H, et al. Intake of Fruits and Vegetables and Risk of Cancer of the Upper Aero-digestive Tract: the Prospective EPIC-study. Cancer Causes Control. 2006;17(7):957-69. PubMed PMID: 16841263.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study. AU - Boeing,Heiner, AU - Dietrich,Thomas, AU - Hoffmann,Kurt, AU - Pischon,Tobias, AU - Ferrari,Pietro, AU - Lahmann,Petra H, AU - Boutron-Ruault,Marie Christine, AU - Clavel-Chapelon,Francoise, AU - Allen,Naomi, AU - Key,Tim, AU - Skeie,Guri, AU - Lund,Eiliv, AU - Olsen,Anja, AU - Tjonneland,Anne, AU - Overvad,Kim, AU - Jensen,Majken K, AU - Rohrmann,Sabine, AU - Linseisen,Jakob, AU - Trichopoulou,Antonia, AU - Bamia,Christina, AU - Psaltopoulou,Theodora, AU - Weinehall,Lars, AU - Johansson,Ingegerd, AU - Sánchez,Maria-José, AU - Jakszyn,Paula, AU - Ardanaz,Eva, AU - Amiano,Pilar, AU - Chirlaque,Maria Dolores, AU - Quirós,J Ramón, AU - Wirfalt,Elisabet, AU - Berglund,Göran, AU - Peeters,Petra H, AU - van Gils,Carla H, AU - Bueno-de-Mesquita,H Bas, AU - Büchner,Frederike L, AU - Berrino,Franco, AU - Palli,Domenico, AU - Sacerdote,Carlotta, AU - Tumino,Rosario, AU - Panico,Salvatore, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Slimani,Nadia, AU - Norat,Teresa, AU - Jenab,Mazda, AU - Riboli,Elio, PY - 2005/11/15/received PY - 2006/04/18/accepted PY - 2006/7/15/pubmed PY - 2006/12/21/medline PY - 2006/7/15/entrez SP - 957 EP - 69 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 17 IS - 7 N2 - Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (<120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/16841263/Intake_of_fruits_and_vegetables_and_risk_of_cancer_of_the_upper_aero_digestive_tract:_the_prospective_EPIC_study_ L2 - https://doi.org/10.1007/s10552-006-0036-4 DB - PRIME DP - Unbound Medicine ER -