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Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn.
FEBS Lett. 2006 Aug 07; 580(18):4306-10.FL

Abstract

Fractalkine (FKN) evokes nociceptive behavior in nai ve rats, whereas minocycline attenuates pain acutely after neuronal injury. We show that, in nai ve rats, FKN causes hyperresponsiveness of lumbar wide dynamic range neurons to brush, pressure and pinch applied to the hindpaw. One day after spinal nerve ligation (SNL), minocycline attenuates after-discharge and responses to brush and pressure. In contrast, minocycline does not alter evoked neuronal responses 10 days after SNL or sciatic constriction, but increases spontaneous discharge. We speculate that microglia rapidly alter sensory neuronal activity in nai ve and neuropathic rats acutely, but not chronically, after injury.

Authors+Show Affiliations

Department of Surgery, Rhode Island Hospital, Brown University School of Medicine, Providence, 02903, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16842787

Citation

Owolabi, Samuel A., and Carl Y. Saab. "Fractalkine and Minocycline Alter Neuronal Activity in the Spinal Cord Dorsal Horn." FEBS Letters, vol. 580, no. 18, 2006, pp. 4306-10.
Owolabi SA, Saab CY. Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. FEBS Lett. 2006;580(18):4306-10.
Owolabi, S. A., & Saab, C. Y. (2006). Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. FEBS Letters, 580(18), 4306-10.
Owolabi SA, Saab CY. Fractalkine and Minocycline Alter Neuronal Activity in the Spinal Cord Dorsal Horn. FEBS Lett. 2006 Aug 7;580(18):4306-10. PubMed PMID: 16842787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fractalkine and minocycline alter neuronal activity in the spinal cord dorsal horn. AU - Owolabi,Samuel A, AU - Saab,Carl Y, Y1 - 2006/07/07/ PY - 2006/04/20/received PY - 2006/06/27/revised PY - 2006/06/28/accepted PY - 2006/7/18/pubmed PY - 2006/9/20/medline PY - 2006/7/18/entrez SP - 4306 EP - 10 JF - FEBS letters JO - FEBS Lett. VL - 580 IS - 18 N2 - Fractalkine (FKN) evokes nociceptive behavior in nai ve rats, whereas minocycline attenuates pain acutely after neuronal injury. We show that, in nai ve rats, FKN causes hyperresponsiveness of lumbar wide dynamic range neurons to brush, pressure and pinch applied to the hindpaw. One day after spinal nerve ligation (SNL), minocycline attenuates after-discharge and responses to brush and pressure. In contrast, minocycline does not alter evoked neuronal responses 10 days after SNL or sciatic constriction, but increases spontaneous discharge. We speculate that microglia rapidly alter sensory neuronal activity in nai ve and neuropathic rats acutely, but not chronically, after injury. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/16842787/Fractalkine_and_minocycline_alter_neuronal_activity_in_the_spinal_cord_dorsal_horn_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(06)00808-8 DB - PRIME DP - Unbound Medicine ER -