Tags

Type your tag names separated by a space and hit enter

Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease.
J Neurol Sci 2006; 249(1):31-8JN

Abstract

OBJECTIVES

Cognitive impairment is a common feature in Parkinson's disease (PD) and is an important predictor of quality of life. Past studies showed that some aspects of cognition, such as working memory, can be enhanced following dopaminergic therapy and transcranial magnetic stimulation. The aim of our study was to investigate whether another form of noninvasive brain stimulation, anodal transcranial direct current stimulation (tDCS), which increases cortical excitability, is associated with a change in a working memory task performance in PD patients.

METHODS

We studied 18 patients (12 men and 6 women) with idiopathic PD. The patients performed a three-back working memory task during active anodal tDCS of the left dorsolateral prefrontal cortex (LDLPFC), anodal tDCS of the primary motor cortex (M1) or sham tDCS. In addition, patients underwent two different types of stimulation with different intensities: 1 and 2 mA.

RESULTS

The results of this study show a significant improvement in working memory as indexed by task accuracy, after active anodal tDCS of the LDLPFC with 2 mA. The other conditions of stimulation: sham tDCS, anodal tDCS of LDLPFC with 1 mA or anodal tDCS of M1 did not result in a significant task performance change.

CONCLUSION

tDCS may exert a beneficial effect on working memory in PD patients that depends on the intensity and site of stimulation. This effect might be explained by the local increase in the excitability of the dorsolateral prefrontal cortex.

Authors+Show Affiliations

Department of Experimental Psychology, University of Sao Paulo, Sao Paulo, Brazil; Núcleo de Neurociências, Mackenzie University, Sao Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16843494

Citation

Boggio, Paulo S., et al. "Effects of Transcranial Direct Current Stimulation On Working Memory in Patients With Parkinson's Disease." Journal of the Neurological Sciences, vol. 249, no. 1, 2006, pp. 31-8.
Boggio PS, Ferrucci R, Rigonatti SP, et al. Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. J Neurol Sci. 2006;249(1):31-8.
Boggio, P. S., Ferrucci, R., Rigonatti, S. P., Covre, P., Nitsche, M., Pascual-Leone, A., & Fregni, F. (2006). Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. Journal of the Neurological Sciences, 249(1), pp. 31-8.
Boggio PS, et al. Effects of Transcranial Direct Current Stimulation On Working Memory in Patients With Parkinson's Disease. J Neurol Sci. 2006 Nov 1;249(1):31-8. PubMed PMID: 16843494.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. AU - Boggio,Paulo S, AU - Ferrucci,Roberta, AU - Rigonatti,Sergio P, AU - Covre,Priscila, AU - Nitsche,Michael, AU - Pascual-Leone,Alvaro, AU - Fregni,Felipe, Y1 - 2006/07/14/ PY - 2006/02/20/received PY - 2006/04/24/revised PY - 2006/05/26/accepted PY - 2006/7/18/pubmed PY - 2007/1/26/medline PY - 2006/7/18/entrez SP - 31 EP - 8 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 249 IS - 1 N2 - OBJECTIVES: Cognitive impairment is a common feature in Parkinson's disease (PD) and is an important predictor of quality of life. Past studies showed that some aspects of cognition, such as working memory, can be enhanced following dopaminergic therapy and transcranial magnetic stimulation. The aim of our study was to investigate whether another form of noninvasive brain stimulation, anodal transcranial direct current stimulation (tDCS), which increases cortical excitability, is associated with a change in a working memory task performance in PD patients. METHODS: We studied 18 patients (12 men and 6 women) with idiopathic PD. The patients performed a three-back working memory task during active anodal tDCS of the left dorsolateral prefrontal cortex (LDLPFC), anodal tDCS of the primary motor cortex (M1) or sham tDCS. In addition, patients underwent two different types of stimulation with different intensities: 1 and 2 mA. RESULTS: The results of this study show a significant improvement in working memory as indexed by task accuracy, after active anodal tDCS of the LDLPFC with 2 mA. The other conditions of stimulation: sham tDCS, anodal tDCS of LDLPFC with 1 mA or anodal tDCS of M1 did not result in a significant task performance change. CONCLUSION: tDCS may exert a beneficial effect on working memory in PD patients that depends on the intensity and site of stimulation. This effect might be explained by the local increase in the excitability of the dorsolateral prefrontal cortex. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/16843494/Effects_of_transcranial_direct_current_stimulation_on_working_memory_in_patients_with_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(06)00280-2 DB - PRIME DP - Unbound Medicine ER -