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The measurement of accurate fetal hemoglobin and related oxygen saturation by the hemoximeter.
Clin Chim Acta. 2006 Dec; 374(1-2):75-80.CC

Abstract

BACKGROUND

The purposes of this study were to examine the accuracy of fetal hemoglobin (HbF) as quickly measured by the hemoximeter, verified by the high-performance liquid chromatography method, and to examine related oxygen saturation (SO(2)) measurements in neonates.

METHODS

Thirty-nine neonates with gestational ages ranging from 25 to 38 weeks were investigated (n=280 blood samples). Twenty younger premature neonates had blood transfusions (n=188 blood samples, 72 before and 116 after transfusions), and 19 older neonates did not.

RESULTS

The bias of the hemoximeter was 23% (+/-9.1) against the HPLC; 25% (+/-7.9) before, and 19% (+/-8.6) after blood transfusions (all P<0.001), for HbF measurements. A regression line (HbFt by the HPLC=8.46+0.7 x HbF by the hemoximeter) has been provided for the prediction. Oxyhemoglobin dissociation curves with the status of (before and after) blood transfusions were presented. In relation to oxygen tension values of 50-75 mm Hg, in addition to the right-shifted oxyhemoglobin dissociation curves, pulse oximeter ranged from 95 to 98% before the transfusions, but decreased to 94 to 96% after the blood transfusions.

CONCLUSIONS

Accurate HbF and related oxygen saturation measurements need to be determined, especially for premature neonates, to minimize the risk of oxygen toxicity.

Links

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Authors+Show Affiliations

Shiao SY
ANA ANCC Magnet Fellow-Appraiser for Nursing Excellence, School of Nursing, University of Texas Health Science Center at Houston, 6901 Bertner Ave. SONSCC 567-8, Houston, Texas 77030, United States. pshiao@earthlink.net
Ou CN
No affiliation info available
Pierantoni H
No affiliation info available

MeSH

Blood TransfusionChromatography, High Pressure LiquidFemaleFetal HemoglobinHumansInfant, NewbornMaleOximetryOxygenOxygen ConsumptionReproducibility of Results

Pub Type(s)

Evaluation Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16844104

Citation

Shiao, Shyang-Yun Pamela K., et al. "The Measurement of Accurate Fetal Hemoglobin and Related Oxygen Saturation By the Hemoximeter." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 374, no. 1-2, 2006, pp. 75-80.
Shiao SY, Ou CN, Pierantoni H. The measurement of accurate fetal hemoglobin and related oxygen saturation by the hemoximeter. Clin Chim Acta. 2006;374(1-2):75-80.
Shiao, S. Y., Ou, C. N., & Pierantoni, H. (2006). The measurement of accurate fetal hemoglobin and related oxygen saturation by the hemoximeter. Clinica Chimica Acta; International Journal of Clinical Chemistry, 374(1-2), 75-80.
Shiao SY, Ou CN, Pierantoni H. The Measurement of Accurate Fetal Hemoglobin and Related Oxygen Saturation By the Hemoximeter. Clin Chim Acta. 2006;374(1-2):75-80. PubMed PMID: 16844104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The measurement of accurate fetal hemoglobin and related oxygen saturation by the hemoximeter. AU - Shiao,Shyang-Yun Pamela K, AU - Ou,Ching-Nan, AU - Pierantoni,Hector, Y1 - 2006/06/06/ PY - 2006/04/18/received PY - 2006/05/15/revised PY - 2006/05/25/accepted PY - 2006/7/18/pubmed PY - 2007/3/17/medline PY - 2006/7/18/entrez SP - 75 EP - 80 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 374 IS - 1-2 N2 - BACKGROUND: The purposes of this study were to examine the accuracy of fetal hemoglobin (HbF) as quickly measured by the hemoximeter, verified by the high-performance liquid chromatography method, and to examine related oxygen saturation (SO(2)) measurements in neonates. METHODS: Thirty-nine neonates with gestational ages ranging from 25 to 38 weeks were investigated (n=280 blood samples). Twenty younger premature neonates had blood transfusions (n=188 blood samples, 72 before and 116 after transfusions), and 19 older neonates did not. RESULTS: The bias of the hemoximeter was 23% (+/-9.1) against the HPLC; 25% (+/-7.9) before, and 19% (+/-8.6) after blood transfusions (all P<0.001), for HbF measurements. A regression line (HbFt by the HPLC=8.46+0.7 x HbF by the hemoximeter) has been provided for the prediction. Oxyhemoglobin dissociation curves with the status of (before and after) blood transfusions were presented. In relation to oxygen tension values of 50-75 mm Hg, in addition to the right-shifted oxyhemoglobin dissociation curves, pulse oximeter ranged from 95 to 98% before the transfusions, but decreased to 94 to 96% after the blood transfusions. CONCLUSIONS: Accurate HbF and related oxygen saturation measurements need to be determined, especially for premature neonates, to minimize the risk of oxygen toxicity. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/16844104/The_measurement_of_accurate_fetal_hemoglobin_and_related_oxygen_saturation_by_the_hemoximeter_ DB - PRIME DP - Unbound Medicine ER -