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Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis.
Clin Gastroenterol Hepatol. 2006 Aug; 4(8):1062-8.CG

Abstract

BACKGROUND & AIMS

Influence of being overweight and diabetes mellitus on the occurrence of hepatocellular carcinoma (HCC) in patients with cirrhosis has not been evaluated prospectively. The aim of this study was to show the predictive value of these factors in a cohort of 771 patients with well-compensated alcohol- or hepatitis C (HCV)-related cirrhosis who were screened prospectively for HCC.

METHODS

The predictive value for HCC occurrence was assessed by using the log-rank test and the Cox proportional hazards model. At enrollment, the mean age was 61.4 +/- 10 years and 431 patients were men. Cirrhosis was caused by alcohol (n = 478), HCV (n = 220), or the association of both factors (n = 73). The mean body mass index (BMI) was 25.4 kg/m(2) and 231 patients were diabetic.

RESULTS

During a mean follow-up period of 4.2 +/- 3 years, 220 patients developed HCC. In univariate analysis, a BMI of 25 kg/m(2) or more, diabetes, male sex, age older than 60 years, and HCV infection were risk factors for HCC. In multivariate analysis, predictive factors were a BMI between 25-30 kg/m(2) (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.4-2.7), BMI of 30 kg/m(2) or more (HR, 2.8; 95% CI, 2.0-4.0), diabetes (HR, 1.6; 95% CI, 1.2-2.1), age 60-70 years (HR, 2.4; 95% CI, 1.3-4.3), age older than 70 years (HR, 3.0; 95% CI, 1.7-5.5), male sex (HR, 2.0; 95% CI, 1.4-2.7), HCV (HR, 1.6; 95% CI, 1.1-2.2), and mixed (HR, 2.6; 95% CI, 1.7-4.0) etiology. We found a positive linear relationship between BMI level and HCC incidence during follow-up evaluation.

CONCLUSIONS

Overweight and diabetes mellitus are associated with an increased risk of HCC occurrence in patients with HCV- or alcohol-related cirrhosis.

Authors+Show Affiliations

Department of Hepatogastroenterology, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, UPRES EA 3409, UFR SMBH, Université Paris 13, Bondy, France. gisele.nkantchou@jvr.ap-hop-paris.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16844421

Citation

N'Kontchou, Gisèle, et al. "Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 4, no. 8, 2006, pp. 1062-8.
N'Kontchou G, Paries J, Htar MT, et al. Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. Clin Gastroenterol Hepatol. 2006;4(8):1062-8.
N'Kontchou, G., Paries, J., Htar, M. T., Ganne-Carrie, N., Costentin, L., Grando-Lemaire, V., Trinchet, J. C., & Beaugrand, M. (2006). Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 4(8), 1062-8.
N'Kontchou G, et al. Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis. Clin Gastroenterol Hepatol. 2006;4(8):1062-8. PubMed PMID: 16844421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for hepatocellular carcinoma in patients with alcoholic or viral C cirrhosis. AU - N'Kontchou,Gisèle, AU - Paries,Jacques, AU - Htar,Myint Tin Tin, AU - Ganne-Carrie,Nathalie, AU - Costentin,Lydie, AU - Grando-Lemaire,Véronique, AU - Trinchet,Jean-Claude, AU - Beaugrand,Michel, Y1 - 2006/07/14/ PY - 2006/7/18/pubmed PY - 2006/11/11/medline PY - 2006/7/18/entrez SP - 1062 EP - 8 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin Gastroenterol Hepatol VL - 4 IS - 8 N2 - BACKGROUND & AIMS: Influence of being overweight and diabetes mellitus on the occurrence of hepatocellular carcinoma (HCC) in patients with cirrhosis has not been evaluated prospectively. The aim of this study was to show the predictive value of these factors in a cohort of 771 patients with well-compensated alcohol- or hepatitis C (HCV)-related cirrhosis who were screened prospectively for HCC. METHODS: The predictive value for HCC occurrence was assessed by using the log-rank test and the Cox proportional hazards model. At enrollment, the mean age was 61.4 +/- 10 years and 431 patients were men. Cirrhosis was caused by alcohol (n = 478), HCV (n = 220), or the association of both factors (n = 73). The mean body mass index (BMI) was 25.4 kg/m(2) and 231 patients were diabetic. RESULTS: During a mean follow-up period of 4.2 +/- 3 years, 220 patients developed HCC. In univariate analysis, a BMI of 25 kg/m(2) or more, diabetes, male sex, age older than 60 years, and HCV infection were risk factors for HCC. In multivariate analysis, predictive factors were a BMI between 25-30 kg/m(2) (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.4-2.7), BMI of 30 kg/m(2) or more (HR, 2.8; 95% CI, 2.0-4.0), diabetes (HR, 1.6; 95% CI, 1.2-2.1), age 60-70 years (HR, 2.4; 95% CI, 1.3-4.3), age older than 70 years (HR, 3.0; 95% CI, 1.7-5.5), male sex (HR, 2.0; 95% CI, 1.4-2.7), HCV (HR, 1.6; 95% CI, 1.1-2.2), and mixed (HR, 2.6; 95% CI, 1.7-4.0) etiology. We found a positive linear relationship between BMI level and HCC incidence during follow-up evaluation. CONCLUSIONS: Overweight and diabetes mellitus are associated with an increased risk of HCC occurrence in patients with HCV- or alcohol-related cirrhosis. SN - 1542-3565 UR - https://www.unboundmedicine.com/medline/citation/16844421/Risk_factors_for_hepatocellular_carcinoma_in_patients_with_alcoholic_or_viral_C_cirrhosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(06)00478-2 DB - PRIME DP - Unbound Medicine ER -