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Resting energy expenditure in cystic fibrosis as an indicator of disease severity.
J Cyst Fibros 2007; 6(2):131-6JC

Abstract

BACKGROUND

An imbalance of energy expenditure has been reported in Cystic Fibrosis (CF). High-energy diets, in combination with pancreatic enzymes, do not always compensate for energy requirements. The aim of this study was to investigate the relation between Resting Energy Expenditure (REE) and disease severity in CF.

METHODS

REE was measured with indirect calorimetry in a group of 38 clinically stable CF patients (32 with pancreatic insufficiency and 6 with pancreatic sufficiency). Correlations between REE and pulmonary function as well as clinical status were studied.

RESULTS

Increased REE expressed as a percentage of predicted (REE%) was demonstrated in pancreatic insufficient CF patients (PI) (113.3+/-2.5%), as compared to pancreatic sufficient (98.9+/-2.5%) and healthy subjects. The elevated REE% in the PI group was not affected by gender and exhibited a strong correlation with the clinical status of the patients (r=-0.641).

CONCLUSIONS

Our data analysis supports the argument that the percentage of predicted REE is an objective indicator of disease severity and progression as well as energy requirements in the assessment of CF patients.

Authors+Show Affiliations

4th Department of Pediatrics, Aristotle University of Thessaloniki, Agias Sofias 9, Pefka, 57010 Thessaloniki, Greece. tmod@med.auth.grNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16844432

Citation

Moudiou, Tatiana, et al. "Resting Energy Expenditure in Cystic Fibrosis as an Indicator of Disease Severity." Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, vol. 6, no. 2, 2007, pp. 131-6.
Moudiou T, Galli-Tsinopoulou A, Vamvakoudis E, et al. Resting energy expenditure in cystic fibrosis as an indicator of disease severity. J Cyst Fibros. 2007;6(2):131-6.
Moudiou, T., Galli-Tsinopoulou, A., Vamvakoudis, E., & Nousia-Arvanitakis, S. (2007). Resting energy expenditure in cystic fibrosis as an indicator of disease severity. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society, 6(2), pp. 131-6.
Moudiou T, et al. Resting Energy Expenditure in Cystic Fibrosis as an Indicator of Disease Severity. J Cyst Fibros. 2007;6(2):131-6. PubMed PMID: 16844432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Resting energy expenditure in cystic fibrosis as an indicator of disease severity. AU - Moudiou,Tatiana, AU - Galli-Tsinopoulou,Assimina, AU - Vamvakoudis,E, AU - Nousia-Arvanitakis,Sanda, Y1 - 2006/07/17/ PY - 2005/11/22/received PY - 2006/05/23/revised PY - 2006/06/01/accepted PY - 2006/7/18/pubmed PY - 2007/6/20/medline PY - 2006/7/18/entrez SP - 131 EP - 6 JF - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JO - J. Cyst. Fibros. VL - 6 IS - 2 N2 - BACKGROUND: An imbalance of energy expenditure has been reported in Cystic Fibrosis (CF). High-energy diets, in combination with pancreatic enzymes, do not always compensate for energy requirements. The aim of this study was to investigate the relation between Resting Energy Expenditure (REE) and disease severity in CF. METHODS: REE was measured with indirect calorimetry in a group of 38 clinically stable CF patients (32 with pancreatic insufficiency and 6 with pancreatic sufficiency). Correlations between REE and pulmonary function as well as clinical status were studied. RESULTS: Increased REE expressed as a percentage of predicted (REE%) was demonstrated in pancreatic insufficient CF patients (PI) (113.3+/-2.5%), as compared to pancreatic sufficient (98.9+/-2.5%) and healthy subjects. The elevated REE% in the PI group was not affected by gender and exhibited a strong correlation with the clinical status of the patients (r=-0.641). CONCLUSIONS: Our data analysis supports the argument that the percentage of predicted REE is an objective indicator of disease severity and progression as well as energy requirements in the assessment of CF patients. SN - 1569-1993 UR - https://www.unboundmedicine.com/medline/citation/16844432/Resting_energy_expenditure_in_cystic_fibrosis_as_an_indicator_of_disease_severity_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1569-1993(06)00091-9 DB - PRIME DP - Unbound Medicine ER -