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The hydrating effect of a cream and white petrolatum measured by optothermal infrared spectrometry in vivo.
Acta Derm Venereol. 1991; 71(5):373-6.AD

Abstract

Optothermal infrared spectrometry (OTIS) is a novel way of measuring the water content of stratum corneum non-invasively. This principle has been used in the present study to evaluate the hydrating effect of a one-week treatment of human skin twice a day with either white petrolatum or a cream (o/w emulsion). Forty-two females volunteered for the study, which comprised one control pretreatment week, one treatment week, and one post-treatment week. White petrolatum was greasy and did not produce any hydrating effect at any point in time when the hydration was measured 10 h after application, whereas the cream produced a clear hydration that became statistically significant from day one of treatment and was maintained for at least 2 days after the treatment was stopped. The hydrating effect amounted to an about 80% increase in those volunteers who had initial values below the mean OTIS value of 23.5%. It is concluded that saturation of the stratum corneum with appropriate lipids and emulsifiers as in the cream leads to hydration of the stratum corneum to about 35% water as measured by the OTIS technique.

Authors+Show Affiliations

Department of Pharmacology, A/S DUMEX, Copenhagen, Denmark.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1684463

Citation

Petersen, E N.. "The Hydrating Effect of a Cream and White Petrolatum Measured By Optothermal Infrared Spectrometry in Vivo." Acta Dermato-venereologica, vol. 71, no. 5, 1991, pp. 373-6.
Petersen EN. The hydrating effect of a cream and white petrolatum measured by optothermal infrared spectrometry in vivo. Acta Derm Venereol. 1991;71(5):373-6.
Petersen, E. N. (1991). The hydrating effect of a cream and white petrolatum measured by optothermal infrared spectrometry in vivo. Acta Dermato-venereologica, 71(5), 373-6.
Petersen EN. The Hydrating Effect of a Cream and White Petrolatum Measured By Optothermal Infrared Spectrometry in Vivo. Acta Derm Venereol. 1991;71(5):373-6. PubMed PMID: 1684463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The hydrating effect of a cream and white petrolatum measured by optothermal infrared spectrometry in vivo. A1 - Petersen,E N, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 373 EP - 6 JF - Acta dermato-venereologica JO - Acta Derm Venereol VL - 71 IS - 5 N2 - Optothermal infrared spectrometry (OTIS) is a novel way of measuring the water content of stratum corneum non-invasively. This principle has been used in the present study to evaluate the hydrating effect of a one-week treatment of human skin twice a day with either white petrolatum or a cream (o/w emulsion). Forty-two females volunteered for the study, which comprised one control pretreatment week, one treatment week, and one post-treatment week. White petrolatum was greasy and did not produce any hydrating effect at any point in time when the hydration was measured 10 h after application, whereas the cream produced a clear hydration that became statistically significant from day one of treatment and was maintained for at least 2 days after the treatment was stopped. The hydrating effect amounted to an about 80% increase in those volunteers who had initial values below the mean OTIS value of 23.5%. It is concluded that saturation of the stratum corneum with appropriate lipids and emulsifiers as in the cream leads to hydration of the stratum corneum to about 35% water as measured by the OTIS technique. SN - 0001-5555 UR - https://www.unboundmedicine.com/medline/citation/1684463/The_hydrating_effect_of_a_cream_and_white_petrolatum_measured_by_optothermal_infrared_spectrometry_in_vivo_ DB - PRIME DP - Unbound Medicine ER -