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Characteristics of patients with sensory neuropathy diagnosed with abnormal small nerve fibres on skin biopsy.
J Neurol Neurosurg Psychiatry. 2006 Aug; 77(8):983-5.JN

Abstract

Clinical, laboratory and electrodiagnostic (EDX) characteristics of 62 patients with sensory neuropathy with abnormal skin biopsies were reviewed. Reduced epidermal nerve fibre density (ENFD) was seen in 71% and morphological changes with normal ENFD were seen in 29% of the patients. Patients with small fibre sensory neuropathy may have associated large fibre loss undetected by routine EDX. Identified associations included abnormal glucose metabolism, Lyme vaccination, monoclonal gammopathy, vitamin B12 deficiency, coeliac disease, and diseases of the connective tissue, inflammatory bowel and thyroid. Sensory neuropathy remained undetermined in 50% of the patients.

Authors+Show Affiliations

Weill Medical College of Cornell University, New York, New York, USA. eadonias@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16844956

Citation

De Sousa, E A., et al. "Characteristics of Patients With Sensory Neuropathy Diagnosed With Abnormal Small Nerve Fibres On Skin Biopsy." Journal of Neurology, Neurosurgery, and Psychiatry, vol. 77, no. 8, 2006, pp. 983-5.
De Sousa EA, Hays AP, Chin RL, et al. Characteristics of patients with sensory neuropathy diagnosed with abnormal small nerve fibres on skin biopsy. J Neurol Neurosurg Psychiatry. 2006;77(8):983-5.
De Sousa, E. A., Hays, A. P., Chin, R. L., Sander, H. W., & Brannagan, T. H. (2006). Characteristics of patients with sensory neuropathy diagnosed with abnormal small nerve fibres on skin biopsy. Journal of Neurology, Neurosurgery, and Psychiatry, 77(8), 983-5.
De Sousa EA, et al. Characteristics of Patients With Sensory Neuropathy Diagnosed With Abnormal Small Nerve Fibres On Skin Biopsy. J Neurol Neurosurg Psychiatry. 2006;77(8):983-5. PubMed PMID: 16844956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of patients with sensory neuropathy diagnosed with abnormal small nerve fibres on skin biopsy. AU - De Sousa,E A, AU - Hays,A P, AU - Chin,R L, AU - Sander,H W, AU - Brannagan,T H,3rd PY - 2006/7/18/pubmed PY - 2006/7/27/medline PY - 2006/7/18/entrez SP - 983 EP - 5 JF - Journal of neurology, neurosurgery, and psychiatry JO - J Neurol Neurosurg Psychiatry VL - 77 IS - 8 N2 - Clinical, laboratory and electrodiagnostic (EDX) characteristics of 62 patients with sensory neuropathy with abnormal skin biopsies were reviewed. Reduced epidermal nerve fibre density (ENFD) was seen in 71% and morphological changes with normal ENFD were seen in 29% of the patients. Patients with small fibre sensory neuropathy may have associated large fibre loss undetected by routine EDX. Identified associations included abnormal glucose metabolism, Lyme vaccination, monoclonal gammopathy, vitamin B12 deficiency, coeliac disease, and diseases of the connective tissue, inflammatory bowel and thyroid. Sensory neuropathy remained undetermined in 50% of the patients. SN - 1468-330X UR - https://www.unboundmedicine.com/medline/citation/16844956/Characteristics_of_patients_with_sensory_neuropathy_diagnosed_with_abnormal_small_nerve_fibres_on_skin_biopsy_ L2 - https://jnnp.bmj.com/lookup/pmidlookup?view=long&pmid=16844956 DB - PRIME DP - Unbound Medicine ER -