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House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study.
Pediatr Allergy Immunol 2006; 17(5):329-36PA

Abstract

Exposure to high allergen levels in early life is a risk factor for the development of allergy. We previously reported limited effects of mite allergen impermeable mattress covers in the prevention and incidence of asthma and mite allergy (PIAMA) cohort at the age of 1 and 2 yr. We now present the results of follow-up at 4 yr objectives. To examine the effects of early reduction of house dust mite (HDM) allergen exposure by means of mattress covers on the incidence of allergy and asthma symptoms in the PIAMA birth cohort at the age of 4 yr. High-risk children (allergic mother) were prenatally recruited and randomly allocated to three groups; receiving mite allergen impermeable mattress covers (n = 416), placebo covers (n = 394) or no intervention (n = 472). At 4 yr of age, atopy was assessed by questionnaire; specific Immunoglobulin E (IgE) to inhalant and food allergens was measured in serum. Dust samples collected from the children's mattresses were analysed for mite allergens. Dermatophagoides farinae1 allergen (Der f 1) levels in dust were reduced in the active group. However, Dermatophagoides pteronissinus 1 (Der p 1) levels, sensitization and atopic symptoms were similar in all groups. We found no effect of mite allergen impermeable mattress covers on sensitization and atopy at 4 yr. Moreover, the allergen reducing effects of the covers had disappeared for one of the two mite allergens that were measured.

Authors+Show Affiliations

Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16846450

Citation

Corver, Karen, et al. "House Dust Mite Allergen Reduction and Allergy at 4 Yr: Follow Up of the PIAMA-study." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 17, no. 5, 2006, pp. 329-36.
Corver K, Kerkhof M, Brussee JE, et al. House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study. Pediatr Allergy Immunol. 2006;17(5):329-36.
Corver, K., Kerkhof, M., Brussee, J. E., Brunekreef, B., van Strien, R. T., Vos, A. P., ... de Jongste, J. C. (2006). House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 17(5), pp. 329-36.
Corver K, et al. House Dust Mite Allergen Reduction and Allergy at 4 Yr: Follow Up of the PIAMA-study. Pediatr Allergy Immunol. 2006;17(5):329-36. PubMed PMID: 16846450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - House dust mite allergen reduction and allergy at 4 yr: follow up of the PIAMA-study. AU - Corver,Karen, AU - Kerkhof,Marjan, AU - Brussee,Jessica E, AU - Brunekreef,Bert, AU - van Strien,Rob T, AU - Vos,Ada P, AU - Smit,Henriette A, AU - Gerritsen,Jorrit, AU - Neijens,Herman J, AU - de Jongste,Johan C, PY - 2006/7/19/pubmed PY - 2006/9/20/medline PY - 2006/7/19/entrez SP - 329 EP - 36 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 17 IS - 5 N2 - Exposure to high allergen levels in early life is a risk factor for the development of allergy. We previously reported limited effects of mite allergen impermeable mattress covers in the prevention and incidence of asthma and mite allergy (PIAMA) cohort at the age of 1 and 2 yr. We now present the results of follow-up at 4 yr objectives. To examine the effects of early reduction of house dust mite (HDM) allergen exposure by means of mattress covers on the incidence of allergy and asthma symptoms in the PIAMA birth cohort at the age of 4 yr. High-risk children (allergic mother) were prenatally recruited and randomly allocated to three groups; receiving mite allergen impermeable mattress covers (n = 416), placebo covers (n = 394) or no intervention (n = 472). At 4 yr of age, atopy was assessed by questionnaire; specific Immunoglobulin E (IgE) to inhalant and food allergens was measured in serum. Dust samples collected from the children's mattresses were analysed for mite allergens. Dermatophagoides farinae1 allergen (Der f 1) levels in dust were reduced in the active group. However, Dermatophagoides pteronissinus 1 (Der p 1) levels, sensitization and atopic symptoms were similar in all groups. We found no effect of mite allergen impermeable mattress covers on sensitization and atopy at 4 yr. Moreover, the allergen reducing effects of the covers had disappeared for one of the two mite allergens that were measured. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/16846450/House_dust_mite_allergen_reduction_and_allergy_at_4_yr:_follow_up_of_the_PIAMA_study_ L2 - https://doi.org/10.1111/j.1399-3038.2006.00410.x DB - PRIME DP - Unbound Medicine ER -