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Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry.
Int J Epidemiol. 2006 Oct; 35(5):1278-85.IJ

Abstract

BACKGROUND

China has the world's largest concentration of smokers (350 million) and rising alcohol consumption, yet little is known about tobacco and alcohol use aetiology. In 2000, the Chinese National Twin Registry was established to provide a genetically informative resource for investigation of health behaviour including tobacco and alcohol use.

METHODS

Using standard twin methodology, this study aimed to examine the relative contribution of genetic and environmental influences on cigarette smoking and alcohol drinking in a sample of adult Chinese twins (n = 1010 individual twins). More than half of the male twins were smokers (58%), and 32.5% reported alcohol consumption. Among male smokers, 46.4% smoked 20 or more cigarettes per day (heavy smokers) and among drinkers, 32.8% consumed one or more drinks per day. Nearly all female twins were non-smokers (99.2%) and non-drinkers (98.7%); therefore, genetic analysis was limited to male data.

RESULTS

In men, current smoking was significantly heritable [75.1%, 95% confidence interval (CI) 56.7-87.5] with no evidence for a significant contribution of shared environmental effects. Heavy smoking was more strongly influenced by genes (66.2%, 95% CI 0-88.4) than shared environment (8.7%, 95% CI 0-71.0). Similarly, current drinking was more strongly influenced by genetic effects (59.5%, 95% CI 0-87.8) than by shared environmental effects (15.3%, 95% CI 0-72.1). Amount of alcohol consumed was influenced to a similar degree by genetic (42.4%, 95% CI 0-91.8) and shared environmental factors (39.2%, 95% CI 0-82.7).

CONCLUSIONS

These results support findings from twins of Western origin on the aetiology of tobacco and alcohol use and encourage further work in Chinese twins.

Authors+Show Affiliations

SRI International, Center for Health Sciences, Menlo Park, CA, USA. christina.lessov-schlaggar@sri.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

16847025

Citation

Lessov-Schlaggar, Christina N., et al. "Heritability of Cigarette Smoking and Alcohol Use in Chinese Male Twins: the Qingdao Twin Registry." International Journal of Epidemiology, vol. 35, no. 5, 2006, pp. 1278-85.
Lessov-Schlaggar CN, Pang Z, Swan GE, et al. Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. Int J Epidemiol. 2006;35(5):1278-85.
Lessov-Schlaggar, C. N., Pang, Z., Swan, G. E., Guo, Q., Wang, S., Cao, W., Unger, J. B., Johnson, C. A., & Lee, L. (2006). Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. International Journal of Epidemiology, 35(5), 1278-85.
Lessov-Schlaggar CN, et al. Heritability of Cigarette Smoking and Alcohol Use in Chinese Male Twins: the Qingdao Twin Registry. Int J Epidemiol. 2006;35(5):1278-85. PubMed PMID: 16847025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heritability of cigarette smoking and alcohol use in Chinese male twins: the Qingdao twin registry. AU - Lessov-Schlaggar,Christina N, AU - Pang,Zengchang, AU - Swan,Gary E, AU - Guo,Qian, AU - Wang,Shaojie, AU - Cao,Weihua, AU - Unger,Jennifer B, AU - Johnson,C Anderson, AU - Lee,Liming, Y1 - 2006/07/17/ PY - 2006/7/19/pubmed PY - 2007/1/11/medline PY - 2006/7/19/entrez SP - 1278 EP - 85 JF - International journal of epidemiology JO - Int J Epidemiol VL - 35 IS - 5 N2 - BACKGROUND: China has the world's largest concentration of smokers (350 million) and rising alcohol consumption, yet little is known about tobacco and alcohol use aetiology. In 2000, the Chinese National Twin Registry was established to provide a genetically informative resource for investigation of health behaviour including tobacco and alcohol use. METHODS: Using standard twin methodology, this study aimed to examine the relative contribution of genetic and environmental influences on cigarette smoking and alcohol drinking in a sample of adult Chinese twins (n = 1010 individual twins). More than half of the male twins were smokers (58%), and 32.5% reported alcohol consumption. Among male smokers, 46.4% smoked 20 or more cigarettes per day (heavy smokers) and among drinkers, 32.8% consumed one or more drinks per day. Nearly all female twins were non-smokers (99.2%) and non-drinkers (98.7%); therefore, genetic analysis was limited to male data. RESULTS: In men, current smoking was significantly heritable [75.1%, 95% confidence interval (CI) 56.7-87.5] with no evidence for a significant contribution of shared environmental effects. Heavy smoking was more strongly influenced by genes (66.2%, 95% CI 0-88.4) than shared environment (8.7%, 95% CI 0-71.0). Similarly, current drinking was more strongly influenced by genetic effects (59.5%, 95% CI 0-87.8) than by shared environmental effects (15.3%, 95% CI 0-72.1). Amount of alcohol consumed was influenced to a similar degree by genetic (42.4%, 95% CI 0-91.8) and shared environmental factors (39.2%, 95% CI 0-82.7). CONCLUSIONS: These results support findings from twins of Western origin on the aetiology of tobacco and alcohol use and encourage further work in Chinese twins. SN - 0300-5771 UR - https://www.unboundmedicine.com/medline/citation/16847025/Heritability_of_cigarette_smoking_and_alcohol_use_in_Chinese_male_twins:_the_Qingdao_twin_registry_ L2 - https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/dyl148 DB - PRIME DP - Unbound Medicine ER -