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Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma.
J Surg Oncol. 2006 Aug 01; 94(2):132-7.JS

Abstract

BACKGROUND AND OBJECTIVES

Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate.

METHODS

One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated.

RESULTS

Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance.

CONCLUSIONS

Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma.

Authors+Show Affiliations

Department of Surgery, Fukuoka Higashi Medical Center, Koga, Fukuoka, Japan. ntvb@med.uoeh-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16847905

Citation

Nozoe, Tadahiro, et al. "Increase in Both CEA and CA19-9 in Sera Is an Independent Prognostic Indicator in Colorectal Carcinoma." Journal of Surgical Oncology, vol. 94, no. 2, 2006, pp. 132-7.
Nozoe T, Rikimaru T, Mori E, et al. Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. J Surg Oncol. 2006;94(2):132-7.
Nozoe, T., Rikimaru, T., Mori, E., Okuyama, T., & Takahashi, I. (2006). Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. Journal of Surgical Oncology, 94(2), 132-7.
Nozoe T, et al. Increase in Both CEA and CA19-9 in Sera Is an Independent Prognostic Indicator in Colorectal Carcinoma. J Surg Oncol. 2006 Aug 1;94(2):132-7. PubMed PMID: 16847905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increase in both CEA and CA19-9 in sera is an independent prognostic indicator in colorectal carcinoma. AU - Nozoe,Tadahiro, AU - Rikimaru,Tatsuya, AU - Mori,Emiko, AU - Okuyama,Toshiro, AU - Takahashi,Ikuo, PY - 2006/7/19/pubmed PY - 2006/8/17/medline PY - 2006/7/19/entrez SP - 132 EP - 7 JF - Journal of surgical oncology JO - J Surg Oncol VL - 94 IS - 2 N2 - BACKGROUND AND OBJECTIVES: Carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) are well known to be the most common tumor markers of colorectal carcinomas. However, the significance of increase in these markers to predict the prognosis of the patients remains a problem for debate. METHODS: One hundred three patients with colorectal carcinoma, who had been treated by resection and reconstruction of digestive tracts were studied. Correlation of preoperative serum value of CEA and CA19-9 with clinicopathologic features including prognosis of the patients was investigated. RESULTS: Preoperative elevation of both of the two markers proved to be an independent prognostic indicator, however, an elevation of only one of the two markers did not obtain a prognostic significance. CONCLUSIONS: Combined data of preoperative increase in CEA and CA19-9 in sera can provide a powerful and useful information to predict prognosis of patients with colorectal carcinoma. SN - 0022-4790 UR - https://www.unboundmedicine.com/medline/citation/16847905/Increase_in_both_CEA_and_CA19_9_in_sera_is_an_independent_prognostic_indicator_in_colorectal_carcinoma_ L2 - https://doi.org/10.1002/jso.20577 DB - PRIME DP - Unbound Medicine ER -