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Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia).
J Agric Food Chem. 2006 Jul 26; 54(15):5336-43.JA

Abstract

Possible anticancer mechanisms exerted by polyphenolic compounds contained in fruits and vegetables include antioxidant activity, the inhibition of proliferation, and the induction of apoptosis in cancer cells. This study examined the effects of four isolated polyphenolic extracts from red muscadine grapes (Vitis rotundifolia) on vital cell parameters and the induction of apoptosis in Caco-2 colon carcinoma cells. The magnitude of effects in cell culture was then correlated to polyphenolic composition and antioxidant capacity. Whereas anticancer effects of individual polyphenolic compounds have been demonstrated multiple times, information relating to anticancer effects of polyphenolic extracts is not available in abundance. All four extracts induced apoptosis, decreased cell number, and caused alterations in cell cycle kinetics in a concentration-dependent manner. The efficacy of the polyphenolics on vital cell parameters correlated well to the presence of ellagic acid glycosides and flavonoids and also to the antioxidant capacity. This study demonstrated the anticancer properties of ellagic acid rich extracts from red muscadine juice.

Authors+Show Affiliations

Department of Pharmaceutics, University of Florida, P. O. Box 110494, Gainesville, Florida 32610-0494, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16848514

Citation

Mertens-Talcott, Susanne U., et al. "Induction of Cell Death in Caco-2 Human Colon Carcinoma Cells By Ellagic Acid Rich Fractions From Muscadine Grapes (Vitis Rotundifolia)." Journal of Agricultural and Food Chemistry, vol. 54, no. 15, 2006, pp. 5336-43.
Mertens-Talcott SU, Lee JH, Percival SS, et al. Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). J Agric Food Chem. 2006;54(15):5336-43.
Mertens-Talcott, S. U., Lee, J. H., Percival, S. S., & Talcott, S. T. (2006). Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). Journal of Agricultural and Food Chemistry, 54(15), 5336-43.
Mertens-Talcott SU, et al. Induction of Cell Death in Caco-2 Human Colon Carcinoma Cells By Ellagic Acid Rich Fractions From Muscadine Grapes (Vitis Rotundifolia). J Agric Food Chem. 2006 Jul 26;54(15):5336-43. PubMed PMID: 16848514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induction of cell death in Caco-2 human colon carcinoma cells by ellagic acid rich fractions from muscadine grapes (Vitis rotundifolia). AU - Mertens-Talcott,Susanne U, AU - Lee,Joon-Hee, AU - Percival,Susan S, AU - Talcott,Stephen T, PY - 2006/7/20/pubmed PY - 2006/8/30/medline PY - 2006/7/20/entrez SP - 5336 EP - 43 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 54 IS - 15 N2 - Possible anticancer mechanisms exerted by polyphenolic compounds contained in fruits and vegetables include antioxidant activity, the inhibition of proliferation, and the induction of apoptosis in cancer cells. This study examined the effects of four isolated polyphenolic extracts from red muscadine grapes (Vitis rotundifolia) on vital cell parameters and the induction of apoptosis in Caco-2 colon carcinoma cells. The magnitude of effects in cell culture was then correlated to polyphenolic composition and antioxidant capacity. Whereas anticancer effects of individual polyphenolic compounds have been demonstrated multiple times, information relating to anticancer effects of polyphenolic extracts is not available in abundance. All four extracts induced apoptosis, decreased cell number, and caused alterations in cell cycle kinetics in a concentration-dependent manner. The efficacy of the polyphenolics on vital cell parameters correlated well to the presence of ellagic acid glycosides and flavonoids and also to the antioxidant capacity. This study demonstrated the anticancer properties of ellagic acid rich extracts from red muscadine juice. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/16848514/Induction_of_cell_death_in_Caco_2_human_colon_carcinoma_cells_by_ellagic_acid_rich_fractions_from_muscadine_grapes__Vitis_rotundifolia__ L2 - https://doi.org/10.1021/jf060563f DB - PRIME DP - Unbound Medicine ER -