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Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders.
Pharm Res. 2006 Aug; 23(8):1898-905.PR

Abstract

PURPOSE

Pharmaceutical tablets are generally produced by compacting a mixture of several ingredients, including active drugs and excipients. It is of practical importance if the properties of such tablets can be predicted on the basis of the ones for constituent components. The purpose of this work is to develop a theoretical model which can predict the tensile strength of compacted multi-component pharmaceutical mixtures.

METHODS

The model was derived on the basis of the Ryshkewitch-Duckworth equation that was originally proposed for porous materials. The required input parameters for the model are the relative density or solid fraction (ratio of the volume of solid materials to the total volume of the tablets) of the multi-component tablets and parameters associated with the constituent single-component powders, which are readily accessible. The tensile strength of tablets made of various powder blends at different relative density was also measured using diametrical compression.

RESULTS

It has been shown that the tensile strength of the multi-component powder compacts is primarily a function of the solid fraction. Excellent agreement between prediction and experimental data for tablets of binary, ternary and four-component blends of some widely used pharmaceutical excipients was obtained.

CONCLUSION

It has been demonstrated that the proposed model can well predict the tensile strength of multi-component pharmaceutical tablets. Thus, the model will be a useful design tool for formulation engineers in the pharmaceutical industry.

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Authors+Show Affiliations

Wu CY
Pfizer Institute for Pharmaceutical Materials Science, Department of Materials Science and Metallurgy, University of Cambridge, Pembroke Street, Cambridge, CB2 3QZ, UK. C.Y.Wu@bham.ac.uk
Best SM
No affiliation info available
Bentham AC
No affiliation info available
Hancock BC
No affiliation info available
Bonfield W
No affiliation info available

MeSH

AlgorithmsChemistry, PharmaceuticalDrug CombinationsDrug CompoundingExcipientsModels, ChemicalParticle SizePorosityPowdersPredictive Value of TestsReproducibility of ResultsTabletsTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16850273

Citation

Wu, Chuan-Yu, et al. "Predicting the Tensile Strength of Compacted Multi-component Mixtures of Pharmaceutical Powders." Pharmaceutical Research, vol. 23, no. 8, 2006, pp. 1898-905.
Wu CY, Best SM, Bentham AC, et al. Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders. Pharm Res. 2006;23(8):1898-905.
Wu, C. Y., Best, S. M., Bentham, A. C., Hancock, B. C., & Bonfield, W. (2006). Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders. Pharmaceutical Research, 23(8), 1898-905.
Wu CY, et al. Predicting the Tensile Strength of Compacted Multi-component Mixtures of Pharmaceutical Powders. Pharm Res. 2006;23(8):1898-905. PubMed PMID: 16850273.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting the tensile strength of compacted multi-component mixtures of pharmaceutical powders. AU - Wu,Chuan-Yu, AU - Best,Serena M, AU - Bentham,A Craig, AU - Hancock,Bruno C, AU - Bonfield,William, PY - 2005/10/14/received PY - 2006/03/06/accepted PY - 2006/7/20/pubmed PY - 2007/1/6/medline PY - 2006/7/20/entrez SP - 1898 EP - 905 JF - Pharmaceutical research JO - Pharm Res VL - 23 IS - 8 N2 - PURPOSE: Pharmaceutical tablets are generally produced by compacting a mixture of several ingredients, including active drugs and excipients. It is of practical importance if the properties of such tablets can be predicted on the basis of the ones for constituent components. The purpose of this work is to develop a theoretical model which can predict the tensile strength of compacted multi-component pharmaceutical mixtures. METHODS: The model was derived on the basis of the Ryshkewitch-Duckworth equation that was originally proposed for porous materials. The required input parameters for the model are the relative density or solid fraction (ratio of the volume of solid materials to the total volume of the tablets) of the multi-component tablets and parameters associated with the constituent single-component powders, which are readily accessible. The tensile strength of tablets made of various powder blends at different relative density was also measured using diametrical compression. RESULTS: It has been shown that the tensile strength of the multi-component powder compacts is primarily a function of the solid fraction. Excellent agreement between prediction and experimental data for tablets of binary, ternary and four-component blends of some widely used pharmaceutical excipients was obtained. CONCLUSION: It has been demonstrated that the proposed model can well predict the tensile strength of multi-component pharmaceutical tablets. Thus, the model will be a useful design tool for formulation engineers in the pharmaceutical industry. SN - 0724-8741 UR - https://www.unboundmedicine.com/medline/citation/16850273/Predicting_the_tensile_strength_of_compacted_multi_component_mixtures_of_pharmaceutical_powders_ L2 - https://doi.org/10.1007/s11095-006-9005-6 DB - PRIME DP - Unbound Medicine ER -