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Maternal ethanol ingestion and somatostatin level and binding in developing rat brain.
Am J Physiol. 1991 Dec; 261(6 Pt 1):E758-63.AJ

Abstract

The effect of maternal ethanol ingestion on 125I-labeled [Tyr11]somatostatin (SS) binding and somatostatin-like immunoreactivity (SLI) in the rat frontoparietal cortex and hippocampus of developing offspring was explored. Female Sprague-Dawley rats were given ethanol in the drinking water before pregnancy, during gestation, and while nursing, whereas controls received a standard diet and fresh water ad libitum. In the ethanol group, food intake decreased as ethanol consumption augmented, with the ethanol calories comprising greater than 30% of the total energy intake during pregnancy. Total energy intake was similar for the ethanol group and normal controls. Maternal alcohol ingestion is associated with an enhanced SLI level in the frontoparietal cortex and hippocampus on the day of birth. This study provided evidence of a selective decrease in SS receptor binding in frontoparietal cortex but not in hippocampus in the 0- to 10-day-old offspring of the ethanol-fed rats. The SS receptor number increased from day 0 to 10 in both control and ethanol groups. However, the affinity appeared to decrease significantly in the ethanol group during this period. At day 30, no differences were found between offspring of control and ethanol-treated rats in any of the parameters. These results suggest that the development of SS receptors in the rat frontoparietal cortex can be transitorily delayed by maternal ethanol ingestion.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, Medical School, University of Alcalá, Alcalá de Henares, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1685069

Citation

Barrios, V, et al. "Maternal Ethanol Ingestion and Somatostatin Level and Binding in Developing Rat Brain." The American Journal of Physiology, vol. 261, no. 6 Pt 1, 1991, pp. E758-63.
Barrios V, Rodríguez-Sánchez MN, Hernandez M, et al. Maternal ethanol ingestion and somatostatin level and binding in developing rat brain. Am J Physiol. 1991;261(6 Pt 1):E758-63.
Barrios, V., Rodríguez-Sánchez, M. N., Hernandez, M., & Arilla, E. (1991). Maternal ethanol ingestion and somatostatin level and binding in developing rat brain. The American Journal of Physiology, 261(6 Pt 1), E758-63.
Barrios V, et al. Maternal Ethanol Ingestion and Somatostatin Level and Binding in Developing Rat Brain. Am J Physiol. 1991;261(6 Pt 1):E758-63. PubMed PMID: 1685069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal ethanol ingestion and somatostatin level and binding in developing rat brain. AU - Barrios,V, AU - Rodríguez-Sánchez,M N, AU - Hernandez,M, AU - Arilla,E, PY - 1991/12/1/pubmed PY - 1991/12/1/medline PY - 1991/12/1/entrez SP - E758 EP - 63 JF - The American journal of physiology JO - Am J Physiol VL - 261 IS - 6 Pt 1 N2 - The effect of maternal ethanol ingestion on 125I-labeled [Tyr11]somatostatin (SS) binding and somatostatin-like immunoreactivity (SLI) in the rat frontoparietal cortex and hippocampus of developing offspring was explored. Female Sprague-Dawley rats were given ethanol in the drinking water before pregnancy, during gestation, and while nursing, whereas controls received a standard diet and fresh water ad libitum. In the ethanol group, food intake decreased as ethanol consumption augmented, with the ethanol calories comprising greater than 30% of the total energy intake during pregnancy. Total energy intake was similar for the ethanol group and normal controls. Maternal alcohol ingestion is associated with an enhanced SLI level in the frontoparietal cortex and hippocampus on the day of birth. This study provided evidence of a selective decrease in SS receptor binding in frontoparietal cortex but not in hippocampus in the 0- to 10-day-old offspring of the ethanol-fed rats. The SS receptor number increased from day 0 to 10 in both control and ethanol groups. However, the affinity appeared to decrease significantly in the ethanol group during this period. At day 30, no differences were found between offspring of control and ethanol-treated rats in any of the parameters. These results suggest that the development of SS receptors in the rat frontoparietal cortex can be transitorily delayed by maternal ethanol ingestion. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/1685069/Maternal_ethanol_ingestion_and_somatostatin_level_and_binding_in_developing_rat_brain_ DB - PRIME DP - Unbound Medicine ER -