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Elevated levels of activated CD4 T cells in common variable immunodeficiency: association with clinical findings.
Allergol Immunopathol (Madr) 2006 Jul-Aug; 34(4):131-5AI

Abstract

BACKGROUND

Common variable immunodeficiency (CVID) is a very heterogeneous syndrome defined by impaired immunoglobulin production. The primary defect remains unknown, but many reports describe peripheral blood T and B lymphocyte dysfunctions in a substantial proportion of CVID patients. Immunophenotypic alterations on memory B lymphocytes correlate with clinical findings. A B-cell-oriented classification principle of the patients has been proposed.

METHODS AND RESULTS

We investigated the expression of activation surface molecules on CD4 and CD8 T-cells from 14 patients with CVID, 6 non-CVID hypogammaglobulinemic patients with recurrent infections, 47 asymptomatic HIV-positive patients without AIDS defining conditions and 23 healthy subjects. Lymphocyte subsets were analysed by three-colour flow cytometry. Monoclonal panel: CD38-FITC/HLADR-PE/CD4 or CD8-PerCP. In CVID patients serum levels of CD4 T-cells co-expressing the activation marker HLA-DR [CD4+DR+ (34 %), CD4+CD38+DR+ (18 %)] were significantly elevated compared with controls. Significant increases in CD8+DR+ (54%), CD8+ CD38+ (43%) and CD8+CD38+DR+ (29%) T-cells were observed in comparison with healthy controls. CVID patients with splenomegaly, lower pre-infusion IgG levels (< 600 mg/dl), autoimmune or lymphoproliferative conditions demonstrated even higher levels of CD4+CD38+DR+T cells (22, 22, 21 and 21% respectively) compared with other CVID patients (13, 13, 15 and 15% respectively).

CONCLUSION

These findings indicate a state of ongoing T lymphocyte activation which is associated with clinical findings frequently observed in CVID.

Authors+Show Affiliations

Immunology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain. carbone@teleline.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16854344

Citation

Carbone, J, et al. "Elevated Levels of Activated CD4 T Cells in Common Variable Immunodeficiency: Association With Clinical Findings." Allergologia Et Immunopathologia, vol. 34, no. 4, 2006, pp. 131-5.
Carbone J, Sarmiento E, Micheloud D, et al. Elevated levels of activated CD4 T cells in common variable immunodeficiency: association with clinical findings. Allergol Immunopathol (Madr). 2006;34(4):131-5.
Carbone, J., Sarmiento, E., Micheloud, D., Rodríguez-Molina, J., & Fernández-Cruz, E. (2006). Elevated levels of activated CD4 T cells in common variable immunodeficiency: association with clinical findings. Allergologia Et Immunopathologia, 34(4), pp. 131-5.
Carbone J, et al. Elevated Levels of Activated CD4 T Cells in Common Variable Immunodeficiency: Association With Clinical Findings. Allergol Immunopathol (Madr). 2006;34(4):131-5. PubMed PMID: 16854344.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated levels of activated CD4 T cells in common variable immunodeficiency: association with clinical findings. AU - Carbone,J, AU - Sarmiento,E, AU - Micheloud,D, AU - Rodríguez-Molina,J, AU - Fernández-Cruz,E, PY - 2006/7/21/pubmed PY - 2007/1/5/medline PY - 2006/7/21/entrez SP - 131 EP - 5 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 34 IS - 4 N2 - BACKGROUND: Common variable immunodeficiency (CVID) is a very heterogeneous syndrome defined by impaired immunoglobulin production. The primary defect remains unknown, but many reports describe peripheral blood T and B lymphocyte dysfunctions in a substantial proportion of CVID patients. Immunophenotypic alterations on memory B lymphocytes correlate with clinical findings. A B-cell-oriented classification principle of the patients has been proposed. METHODS AND RESULTS: We investigated the expression of activation surface molecules on CD4 and CD8 T-cells from 14 patients with CVID, 6 non-CVID hypogammaglobulinemic patients with recurrent infections, 47 asymptomatic HIV-positive patients without AIDS defining conditions and 23 healthy subjects. Lymphocyte subsets were analysed by three-colour flow cytometry. Monoclonal panel: CD38-FITC/HLADR-PE/CD4 or CD8-PerCP. In CVID patients serum levels of CD4 T-cells co-expressing the activation marker HLA-DR [CD4+DR+ (34 %), CD4+CD38+DR+ (18 %)] were significantly elevated compared with controls. Significant increases in CD8+DR+ (54%), CD8+ CD38+ (43%) and CD8+CD38+DR+ (29%) T-cells were observed in comparison with healthy controls. CVID patients with splenomegaly, lower pre-infusion IgG levels (< 600 mg/dl), autoimmune or lymphoproliferative conditions demonstrated even higher levels of CD4+CD38+DR+T cells (22, 22, 21 and 21% respectively) compared with other CVID patients (13, 13, 15 and 15% respectively). CONCLUSION: These findings indicate a state of ongoing T lymphocyte activation which is associated with clinical findings frequently observed in CVID. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/16854344/Elevated_levels_of_activated_CD4_T_cells_in_common_variable_immunodeficiency:_association_with_clinical_findings_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0301-0546/34/131 DB - PRIME DP - Unbound Medicine ER -