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Nicotine and cotinine levels in body fluids of smokers who committed suicide.
Forensic Sci Int. 2007 May 24; 168(2-3):102-5.FS

Abstract

Cigarette smoking is associated with a higher risk for suicide. The present study was conducted on the hypothesis that suicide smokers show higher nicotine and cotinine levels in blood and urine than non-suicide smokers. We determined nicotine and cotinine levels in blood and urine of 87 deceased individuals (18 suicides and 69 non-suicides) by gas chromatography. The smoking rate was 77.8% for individuals who committed suicide and 42.0% for those who did not commit suicide. Average nicotine and cotinine levels in blood were significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 93.2+/-46.6 ng/ml versus 25.8+/-14.4 ng/ml, p<0.0001 and cotinine: 378+/-235 ng/ml versus 201+/-137 ng/ml, p<0.005). Average levels of urinary nicotine and cotinine were also significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 1980+/-2210 ng/ml versus 394+/-376 ng/ml, p<0.005 and cotinine: 1170+/-1330 ng/ml versus 414+/-290 ng/ml, p<0.05). Twenty-six decedents were intoxicated with alcohol, and they included 7 suicides (7 smokers) and 19 non-suicides (15 smokers). Our data suggest that cigarette smokers who commit suicide smoke more heavily than other cigarette smokers.

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Authors+Show Affiliations

Moriya F
Department of Legal Medicine, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, Kochi 783-8505, Japan. moriyaf@med.kochi-u.ac.jp
Hashimoto Y
No affiliation info available
Furumiya J
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAlcohol DrinkingCase-Control StudiesCause of DeathComorbidityCotinineFemaleHumansJapanMaleMental DisordersMiddle AgedNicotineSmokingSuicide

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16854545

Citation

Moriya, Fumio, et al. "Nicotine and Cotinine Levels in Body Fluids of Smokers Who Committed Suicide." Forensic Science International, vol. 168, no. 2-3, 2007, pp. 102-5.
Moriya F, Hashimoto Y, Furumiya J. Nicotine and cotinine levels in body fluids of smokers who committed suicide. Forensic Sci Int. 2007;168(2-3):102-5.
Moriya, F., Hashimoto, Y., & Furumiya, J. (2007). Nicotine and cotinine levels in body fluids of smokers who committed suicide. Forensic Science International, 168(2-3), 102-5.
Moriya F, Hashimoto Y, Furumiya J. Nicotine and Cotinine Levels in Body Fluids of Smokers Who Committed Suicide. Forensic Sci Int. 2007 May 24;168(2-3):102-5. PubMed PMID: 16854545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nicotine and cotinine levels in body fluids of smokers who committed suicide. AU - Moriya,Fumio, AU - Hashimoto,Yoshiaki, AU - Furumiya,Junichi, Y1 - 2006/07/18/ PY - 2006/02/24/received PY - 2006/06/10/revised PY - 2006/06/18/accepted PY - 2006/7/21/pubmed PY - 2007/7/10/medline PY - 2006/7/21/entrez SP - 102 EP - 5 JF - Forensic science international JO - Forensic Sci Int VL - 168 IS - 2-3 N2 - Cigarette smoking is associated with a higher risk for suicide. The present study was conducted on the hypothesis that suicide smokers show higher nicotine and cotinine levels in blood and urine than non-suicide smokers. We determined nicotine and cotinine levels in blood and urine of 87 deceased individuals (18 suicides and 69 non-suicides) by gas chromatography. The smoking rate was 77.8% for individuals who committed suicide and 42.0% for those who did not commit suicide. Average nicotine and cotinine levels in blood were significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 93.2+/-46.6 ng/ml versus 25.8+/-14.4 ng/ml, p<0.0001 and cotinine: 378+/-235 ng/ml versus 201+/-137 ng/ml, p<0.005). Average levels of urinary nicotine and cotinine were also significantly higher in the suicide smokers than in the non-suicide smokers (nicotine: 1980+/-2210 ng/ml versus 394+/-376 ng/ml, p<0.005 and cotinine: 1170+/-1330 ng/ml versus 414+/-290 ng/ml, p<0.05). Twenty-six decedents were intoxicated with alcohol, and they included 7 suicides (7 smokers) and 19 non-suicides (15 smokers). Our data suggest that cigarette smokers who commit suicide smoke more heavily than other cigarette smokers. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/16854545/Nicotine_and_cotinine_levels_in_body_fluids_of_smokers_who_committed_suicide_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(06)00450-6 DB - PRIME DP - Unbound Medicine ER -