Secondary cutaneous effects of hydroxyurea: possible pathogenetic mechanisms.J Dermatolog Treat. 2006; 17(3):176-8.JD
We report the case of a 73-year-old man who had been on hydroxyurea for essential thrombocythemia since 1988. After 12 years of treatment he developed a symmetrical dermatomyositis-like eruption together with a leg ulceration and five squamous cell carcinomas of the face. The possible pathogenetic mechanisms of these known side effects are discussed.