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Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study.
J Hum Hypertens. 2006 Nov; 20(11):850-9.JH

Abstract

The integrated relationship between inflammation, obesity and cardiovascular disease is currently a subject of much research interest. These specific relationships, however, have not been studied in-depth in South African population groups in order to determine the role of ethnicity. It is known that Africans, compared to Caucasians, suffer from a high prevalence of hypertension. It was therefore hypothesized that the levels of inflammatory markers (high-sensitivity C-reactive protein (hsCRP), fibrinogen and leptin) are higher in Africans compared to Caucasians and are notably associated with cardiovascular dysfunction in Africans. Apparently healthy African (N=102) and Caucasian (N=115) women, matched for age and body mass index (BMI), were recruited. Leptin, hsCRP, fibrinogen and lipid levels, waist circumference (WC), BMI, systolic and diastolic blood pressure, cardiac output (CO), total peripheral resistance (TPR) and Windkessel compliance were measured. Results showed that the levels of leptin, hsCRP and fibrinogen were significantly higher (P<0.05) in the African women. The inflammatory markers correlated strongly with cardiovascular parameters, age and obesity (BMI, WC) in both groups, but after adjusting for age and obesity, none of the correlations were significant anymore. Multiple regression analyses (with leptin, hsCRP or fibrinogen as dependent variable) showed that only leptin levels of African women were explained by cardiovascular parameters (BP, TPR and CO). In conclusion, even though African women had significantly higher leptin, hsCRP, fibrinogen and blood pressure levels than Caucasian women, no cardiovascular parameters explained the variation in the inflammatory markers (except for leptin levels of African women).

Authors+Show Affiliations

School for Physiology, Nutrition and Consumer Sciences, North-West University, Potchefstroom, North-West Province 2520, South Africa. flgaes@puk.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16855625

Citation

Schutte, A E., et al. "Inflammation, Obesity and Cardiovascular Function in African and Caucasian Women From South Africa: the POWIRS Study." Journal of Human Hypertension, vol. 20, no. 11, 2006, pp. 850-9.
Schutte AE, van Vuuren D, van Rooyen JM, et al. Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study. J Hum Hypertens. 2006;20(11):850-9.
Schutte, A. E., van Vuuren, D., van Rooyen, J. M., Huisman, H. W., Schutte, R., Malan, L., & Malan, N. T. (2006). Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study. Journal of Human Hypertension, 20(11), 850-9.
Schutte AE, et al. Inflammation, Obesity and Cardiovascular Function in African and Caucasian Women From South Africa: the POWIRS Study. J Hum Hypertens. 2006;20(11):850-9. PubMed PMID: 16855625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammation, obesity and cardiovascular function in African and Caucasian women from South Africa: the POWIRS study. AU - Schutte,A E, AU - van Vuuren,D, AU - van Rooyen,J M, AU - Huisman,H W, AU - Schutte,R, AU - Malan,L, AU - Malan,N T, Y1 - 2006/07/20/ PY - 2006/7/21/pubmed PY - 2007/2/27/medline PY - 2006/7/21/entrez SP - 850 EP - 9 JF - Journal of human hypertension JO - J Hum Hypertens VL - 20 IS - 11 N2 - The integrated relationship between inflammation, obesity and cardiovascular disease is currently a subject of much research interest. These specific relationships, however, have not been studied in-depth in South African population groups in order to determine the role of ethnicity. It is known that Africans, compared to Caucasians, suffer from a high prevalence of hypertension. It was therefore hypothesized that the levels of inflammatory markers (high-sensitivity C-reactive protein (hsCRP), fibrinogen and leptin) are higher in Africans compared to Caucasians and are notably associated with cardiovascular dysfunction in Africans. Apparently healthy African (N=102) and Caucasian (N=115) women, matched for age and body mass index (BMI), were recruited. Leptin, hsCRP, fibrinogen and lipid levels, waist circumference (WC), BMI, systolic and diastolic blood pressure, cardiac output (CO), total peripheral resistance (TPR) and Windkessel compliance were measured. Results showed that the levels of leptin, hsCRP and fibrinogen were significantly higher (P<0.05) in the African women. The inflammatory markers correlated strongly with cardiovascular parameters, age and obesity (BMI, WC) in both groups, but after adjusting for age and obesity, none of the correlations were significant anymore. Multiple regression analyses (with leptin, hsCRP or fibrinogen as dependent variable) showed that only leptin levels of African women were explained by cardiovascular parameters (BP, TPR and CO). In conclusion, even though African women had significantly higher leptin, hsCRP, fibrinogen and blood pressure levels than Caucasian women, no cardiovascular parameters explained the variation in the inflammatory markers (except for leptin levels of African women). SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/16855625/Inflammation_obesity_and_cardiovascular_function_in_African_and_Caucasian_women_from_South_Africa:_the_POWIRS_study_ L2 - https://doi.org/10.1038/sj.jhh.1002065 DB - PRIME DP - Unbound Medicine ER -