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Carvedilol (Kredex) reduces infarct size in a canine model of acute myocardial infarction.
Pharmacology. 1991; 43(3):113-20.P

Abstract

Carvedilol (Kredex) is a multiple action, antihypertensive agent that may also prove to be useful in the treatment of angina and congestive heart failure. Carvedilol combines in one molecule both beta-adrenoceptor blocking and vasodilating activities. Inasmuch as beta-adrenoceptor blocking agents are known to be cardioprotective and thereby reduce infarct size, it is logical to assume that carvedilol, likewise, would possess this desirable activity. Furthermore, the additional vasodilating activity of carvedilol could contribute to further reductions in infarct size by reducing myocardial work (and therefore myocardial oxygen demand) through reductions in both afterload and myocardial wall tension. As such, we have investigated the ability of carvedilol to reduce infarct size in a canine model of acute myocardial infarction. Carvedilol (1 mg/kg i.v.) or its vehicle, dimethylformamide, were administered 15 min before left circumflex coronary artery (LCX) occlusion. Following 1 h of LCX occlusion, dogs were reperfused through a critical stenosis and then allowed to recover for 24 h. Carvedilol-treated animals exhibited a 78% reduction in infarct size compared to vehicle controls, such that the percentage of the left ventricle infarcted was reduced significantly from 16.2 +/- 4.1% in control animals to 3.6 +/- 1.3% in animals treated with carvedilol (p = 0.017, n = 6). Stained tissue sections of the left ventricle were photographed, digitized and color-enhanced using an Image Analysis Computer System, and three-dimensional reconstruction of the left ventricle, including the infarcted areas, was performed.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia, Pa.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1685569

Citation

Hamburger, S A., et al. "Carvedilol (Kredex) Reduces Infarct Size in a Canine Model of Acute Myocardial Infarction." Pharmacology, vol. 43, no. 3, 1991, pp. 113-20.
Hamburger SA, Barone FC, Feuerstein GZ, et al. Carvedilol (Kredex) reduces infarct size in a canine model of acute myocardial infarction. Pharmacology. 1991;43(3):113-20.
Hamburger, S. A., Barone, F. C., Feuerstein, G. Z., & Ruffolo, R. R. (1991). Carvedilol (Kredex) reduces infarct size in a canine model of acute myocardial infarction. Pharmacology, 43(3), 113-20.
Hamburger SA, et al. Carvedilol (Kredex) Reduces Infarct Size in a Canine Model of Acute Myocardial Infarction. Pharmacology. 1991;43(3):113-20. PubMed PMID: 1685569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carvedilol (Kredex) reduces infarct size in a canine model of acute myocardial infarction. AU - Hamburger,S A, AU - Barone,F C, AU - Feuerstein,G Z, AU - Ruffolo,R R,Jr PY - 1991/1/11/pubmed PY - 2001/3/28/medline PY - 1991/1/11/entrez SP - 113 EP - 20 JF - Pharmacology JO - Pharmacology VL - 43 IS - 3 N2 - Carvedilol (Kredex) is a multiple action, antihypertensive agent that may also prove to be useful in the treatment of angina and congestive heart failure. Carvedilol combines in one molecule both beta-adrenoceptor blocking and vasodilating activities. Inasmuch as beta-adrenoceptor blocking agents are known to be cardioprotective and thereby reduce infarct size, it is logical to assume that carvedilol, likewise, would possess this desirable activity. Furthermore, the additional vasodilating activity of carvedilol could contribute to further reductions in infarct size by reducing myocardial work (and therefore myocardial oxygen demand) through reductions in both afterload and myocardial wall tension. As such, we have investigated the ability of carvedilol to reduce infarct size in a canine model of acute myocardial infarction. Carvedilol (1 mg/kg i.v.) or its vehicle, dimethylformamide, were administered 15 min before left circumflex coronary artery (LCX) occlusion. Following 1 h of LCX occlusion, dogs were reperfused through a critical stenosis and then allowed to recover for 24 h. Carvedilol-treated animals exhibited a 78% reduction in infarct size compared to vehicle controls, such that the percentage of the left ventricle infarcted was reduced significantly from 16.2 +/- 4.1% in control animals to 3.6 +/- 1.3% in animals treated with carvedilol (p = 0.017, n = 6). Stained tissue sections of the left ventricle were photographed, digitized and color-enhanced using an Image Analysis Computer System, and three-dimensional reconstruction of the left ventricle, including the infarcted areas, was performed.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0031-7012 UR - https://www.unboundmedicine.com/medline/citation/1685569/Carvedilol__Kredex__reduces_infarct_size_in_a_canine_model_of_acute_myocardial_infarction_ L2 - https://www.karger.com?DOI=10.1159/000138836 DB - PRIME DP - Unbound Medicine ER -