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Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease.
Acta Neuropathol. 2006 Sep; 112(3):261-5.AN

Abstract

We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according to differences in alpha-synuclein immunoreactivity: (1) neurons without pale bodies or Lewy bodies, (2) neurons with pale bodies, and (3) neurons with Lewy bodies. In controls, we did not observe fragmented GA in nigral neurons by immunocytochemistry with an anti-TGN46 antibody. In PD, the GA was fragmented in 3% of the nigral neurons without inclusions, and in 5% of the neurons with Lewy bodies. In contrast, fragmented GA was noted in 19% of the neurons containing pale bodies. Since pale bodies represent early stages in the development of brainstem Lewy bodies, our results suggest that the cytotoxicity of alpha-synuclein-positive aggregates is reduced in the process of Lewy body formation.

Authors+Show Affiliations

Department of Neurology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan. yfujita@showa.gunma-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16855830

Citation

Fujita, Yukio, et al. "Fragmentation of Golgi Apparatus of Nigral Neurons With Alpha-synuclein-positive Inclusions in Patients With Parkinson's Disease." Acta Neuropathologica, vol. 112, no. 3, 2006, pp. 261-5.
Fujita Y, Ohama E, Takatama M, et al. Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Acta Neuropathol. 2006;112(3):261-5.
Fujita, Y., Ohama, E., Takatama, M., Al-Sarraj, S., & Okamoto, K. (2006). Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Acta Neuropathologica, 112(3), 261-5.
Fujita Y, et al. Fragmentation of Golgi Apparatus of Nigral Neurons With Alpha-synuclein-positive Inclusions in Patients With Parkinson's Disease. Acta Neuropathol. 2006;112(3):261-5. PubMed PMID: 16855830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. AU - Fujita,Yukio, AU - Ohama,Eisaku, AU - Takatama,Masamitsu, AU - Al-Sarraj,Safa, AU - Okamoto,Koichi, Y1 - 2006/07/20/ PY - 2006/03/07/received PY - 2006/06/27/accepted PY - 2006/06/19/revised PY - 2006/7/21/pubmed PY - 2007/2/9/medline PY - 2006/7/21/entrez SP - 261 EP - 5 JF - Acta neuropathologica JO - Acta Neuropathol VL - 112 IS - 3 N2 - We examined whether the Golgi apparatus (GA) is fragmented in nigral neurons in 18 cases with Parkinson's disease (PD) and in 8 control cases. The nigral neurons in cases with PD showed various degrees of Lewy pathology with alpha-synuclein immunohistochemistry, and we divided the neurons into three subtypes according to differences in alpha-synuclein immunoreactivity: (1) neurons without pale bodies or Lewy bodies, (2) neurons with pale bodies, and (3) neurons with Lewy bodies. In controls, we did not observe fragmented GA in nigral neurons by immunocytochemistry with an anti-TGN46 antibody. In PD, the GA was fragmented in 3% of the nigral neurons without inclusions, and in 5% of the neurons with Lewy bodies. In contrast, fragmented GA was noted in 19% of the neurons containing pale bodies. Since pale bodies represent early stages in the development of brainstem Lewy bodies, our results suggest that the cytotoxicity of alpha-synuclein-positive aggregates is reduced in the process of Lewy body formation. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/16855830/Fragmentation_of_Golgi_apparatus_of_nigral_neurons_with_alpha_synuclein_positive_inclusions_in_patients_with_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s00401-006-0114-4 DB - PRIME DP - Unbound Medicine ER -