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[The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Jun; 23(3):587-91.SW

Abstract

The hydroxypropyl methylcellulose (HPMC) matrix tablet containing metoprolol succinate (MS) as a model drug was obtained by wet method compression tablet. The effects of the amount and viscosity of HPMC, the preparation method, compressing pressure, the amount of ethycellulose (EC), the pH of dissolution medium and the speed of basket rotation on the drug release from the matrix tablets were evaluated. The results showed that the release rate of metoprolol succinate from HPMC matrix tablets followed Higuchi equation. The release mechanism was in line with the synthetical effect of diffusion and corrosion. Drug release was influenced by the amount and viscosity of HPMC, the amount of EC in matrices, the preparation method and compressing pressure, etc. Drug release was not influenced by the pH of dissolution medium used, and not by the speed of basket rotation, either.

Authors+Show Affiliations

Institute of Drug Preparations, School of Pharmacy, Shandong University, Ji'nan 250012, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16856395

Citation

Huang, Guihua, et al. "[The Factors Influencing Metoprolol Succinate Release From Hydroxypropyl Methylcellulose Matrix Tablet]." Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, vol. 23, no. 3, 2006, pp. 587-91.
Huang G, Wang R, Wang D, et al. [The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23(3):587-91.
Huang, G., Wang, R., Wang, D., Zhang, Z., & Deng, S. (2006). [The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, 23(3), 587-91.
Huang G, et al. [The Factors Influencing Metoprolol Succinate Release From Hydroxypropyl Methylcellulose Matrix Tablet]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23(3):587-91. PubMed PMID: 16856395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The factors influencing metoprolol succinate release from hydroxypropyl methylcellulose matrix tablet]. AU - Huang,Guihua, AU - Wang,Rongmei, AU - Wang,Defeng, AU - Zhang,Zhiwen, AU - Deng,Shuhai, PY - 2006/7/22/pubmed PY - 2007/3/7/medline PY - 2006/7/22/entrez SP - 587 EP - 91 JF - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi JO - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi VL - 23 IS - 3 N2 - The hydroxypropyl methylcellulose (HPMC) matrix tablet containing metoprolol succinate (MS) as a model drug was obtained by wet method compression tablet. The effects of the amount and viscosity of HPMC, the preparation method, compressing pressure, the amount of ethycellulose (EC), the pH of dissolution medium and the speed of basket rotation on the drug release from the matrix tablets were evaluated. The results showed that the release rate of metoprolol succinate from HPMC matrix tablets followed Higuchi equation. The release mechanism was in line with the synthetical effect of diffusion and corrosion. Drug release was influenced by the amount and viscosity of HPMC, the amount of EC in matrices, the preparation method and compressing pressure, etc. Drug release was not influenced by the pH of dissolution medium used, and not by the speed of basket rotation, either. SN - 1001-5515 UR - https://www.unboundmedicine.com/medline/citation/16856395/[The_factors_influencing_metoprolol_succinate_release_from_hydroxypropyl_methylcellulose_matrix_tablet]_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:16856395 DB - PRIME DP - Unbound Medicine ER -