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[Preparation of ondansetron hydrochloride sustained-release tablet evaluation of its and drug release behavior in vitro].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Jun; 23(3):597-600, 614.SW

Abstract

For the purpose of preparing the ondansetron hydrochloride sustained-release tablets and studying the influencing factors, we prepared the ondansetron hydrochloride sustained-release tablets, using hydroxypropylmethylcellose (HPMC) as the matrix material. Then we investigated the effects of the viscosity and amount of HPMC,the sort of fillers, the preparation methods, the alcohol content in adhesives, and the pH of the dissolving solution on the release of ondansetron hydrochloride from sustained-release tablets. On the basis of pharmaceutical preformulation studies,the best formulation and preparation methods were screened out according to orthogonal experiment design method. The release behavior of the tablets followed the Higuchi equation. The viscosity of HPMC,the sort of fillers and the rotation speed had no significant effects on the release of ondansetron hydrochloride sustained-release tablets,while the preparation methods, the alcohol content in adhesives and the pH of the dissolving solution influcenced the release of ondansetron hydrochloride sustained-release tablets significantly. Ondansetron hydrochloride sustained-release tablets had good drug relase behavior for in 12 h in vitro.

Authors+Show Affiliations

Zhang Y
College of Pharmacy, Shandong University, Ji'nan 250012, China. zhy6789@126.com
Huang G
No affiliation info available
Yu Y
No affiliation info available
Han J
No affiliation info available
Yu P
No affiliation info available

MeSH

Delayed-Action PreparationsLactoseMethylcelluloseModels, ChemicalOndansetronPharmaceutical PreparationsTabletsViscosity

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16856397

Citation

Zhang, Yuhong, et al. "[Preparation of Ondansetron Hydrochloride Sustained-release Tablet Evaluation of Its and Drug Release Behavior in Vitro]." Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, vol. 23, no. 3, 2006, pp. 597-600, 614.
Zhang Y, Huang G, Yu Y, et al. [Preparation of ondansetron hydrochloride sustained-release tablet evaluation of its and drug release behavior in vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23(3):597-600, 614.
Zhang, Y., Huang, G., Yu, Y., Han, J., & Yu, P. (2006). [Preparation of ondansetron hydrochloride sustained-release tablet evaluation of its and drug release behavior in vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, 23(3), 597-600, 614.
Zhang Y, et al. [Preparation of Ondansetron Hydrochloride Sustained-release Tablet Evaluation of Its and Drug Release Behavior in Vitro]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006;23(3):597-600, 614. PubMed PMID: 16856397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Preparation of ondansetron hydrochloride sustained-release tablet evaluation of its and drug release behavior in vitro]. AU - Zhang,Yuhong, AU - Huang,Guihua, AU - Yu,Yanling, AU - Han,Jingbin, AU - Yu,Ping, PY - 2006/7/22/pubmed PY - 2007/3/7/medline PY - 2006/7/22/entrez SP - 597-600, 614 JF - Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi JO - Sheng Wu Yi Xue Gong Cheng Xue Za Zhi VL - 23 IS - 3 N2 - For the purpose of preparing the ondansetron hydrochloride sustained-release tablets and studying the influencing factors, we prepared the ondansetron hydrochloride sustained-release tablets, using hydroxypropylmethylcellose (HPMC) as the matrix material. Then we investigated the effects of the viscosity and amount of HPMC,the sort of fillers, the preparation methods, the alcohol content in adhesives, and the pH of the dissolving solution on the release of ondansetron hydrochloride from sustained-release tablets. On the basis of pharmaceutical preformulation studies,the best formulation and preparation methods were screened out according to orthogonal experiment design method. The release behavior of the tablets followed the Higuchi equation. The viscosity of HPMC,the sort of fillers and the rotation speed had no significant effects on the release of ondansetron hydrochloride sustained-release tablets,while the preparation methods, the alcohol content in adhesives and the pH of the dissolving solution influcenced the release of ondansetron hydrochloride sustained-release tablets significantly. Ondansetron hydrochloride sustained-release tablets had good drug relase behavior for in 12 h in vitro. SN - 1001-5515 UR - https://www.unboundmedicine.com/medline/citation/16856397/[Preparation_of_ondansetron_hydrochloride_sustained_release_tablet_evaluation_of_its_and_drug_release_behavior_in_vitro]_ L2 - https://medlineplus.gov/medicines.html DB - PRIME DP - Unbound Medicine ER -