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[Separation and identification of active constituents of Paris vietnamensis].
Yao Xue Xue Bao. 2006 Apr; 41(4):361-4.YX

Abstract

AIM

To study the anti-tumor bioactive steroid saponins of Paris vietnamensis (Takht.).

METHODS

The constituents were isolated and purified by chromatography and their structures were identified by spectral analysis and physicochemical properties. The cytotoxic bioactivities of the constituents were determined by MTT.

RESULTS

Eleven compounds were obtained and identified as 3beta, 5alpha,6alpha-trihydroxy-7(8)-en-isospirostanol-3-O-beta-D-glucopyranosyl(1-->3) [alpha-L-rhamnopyranosyl(1-->2)]-beta-D-glucopyranoside (1), which was named as parisvietnaside A, 25 (R) diosgenin-3-O-alpha-L-arabinofuranosyl(1-->4)-beta-D-glucopyranoside (2), 25(R) diosgenin-3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranoside (3), 25 (R) diosgenin-3-O-alpha-L-arabinofuranosyl (1-->4) [alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glucopyranoside (4), 25 (R) diosgenin-3-O-beta-D-glucopyranosyl (1-->3) [alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glucopyranoside (5), 25 (R) diosgenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl(1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (6), 25 (R) pennogenin-3-O-alpha-L-arabinofuranosyl(1-->4)-beta-D-glucopyranoside (7), 25 (R) pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranoside (8), 25 (R) pennogenin-3-O-alpha-L-arabinofuranosyl (1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (9), 25 (R) pennogenin-3-O-beta-D-glycopyranosyl (1-->3) [alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranoside (10) and 25 (R) pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl(1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (11). Some constituents had cytotoxic bioactivities.

CONCLUSION

Compound 1 is a new spirostanol saponin, and compounds 2, 3, 6-11 were obtained from Paris vietnamensis (Takht.) for the first time. Compounds 3, 4, 6, 8 had cytotoxic bioactivities against tumor cells HepG2 and SGC-7901.

Authors+Show Affiliations

Huang Y
Department of Pharmacognosy, Hebei Medical Universty, Shijiazhuang, China.
Cui LJ
No affiliation info available
Wang Q
No affiliation info available
Ye WC
No affiliation info available

MeSH

AdenocarcinomaCarcinoma, HepatocellularCell Line, TumorCell ProliferationHumansLiliaceaeLiver NeoplasmsMolecular ConformationMolecular StructurePlants, MedicinalRhizomeSaponinsStomach Neoplasms

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16856484

Citation

Huang, Yun, et al. "[Separation and Identification of Active Constituents of Paris Vietnamensis]." Yao Xue Xue Bao = Acta Pharmaceutica Sinica, vol. 41, no. 4, 2006, pp. 361-4.
Huang Y, Cui LJ, Wang Q, et al. [Separation and identification of active constituents of Paris vietnamensis]. Yao Xue Xue Bao. 2006;41(4):361-4.
Huang, Y., Cui, L. J., Wang, Q., & Ye, W. C. (2006). [Separation and identification of active constituents of Paris vietnamensis]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica, 41(4), 361-4.
Huang Y, et al. [Separation and Identification of Active Constituents of Paris Vietnamensis]. Yao Xue Xue Bao. 2006;41(4):361-4. PubMed PMID: 16856484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Separation and identification of active constituents of Paris vietnamensis]. AU - Huang,Yun, AU - Cui,Li-jian, AU - Wang,Qiang, AU - Ye,Wen-cai, PY - 2006/7/22/pubmed PY - 2007/10/20/medline PY - 2006/7/22/entrez SP - 361 EP - 4 JF - Yao xue xue bao = Acta pharmaceutica Sinica JO - Yao Xue Xue Bao VL - 41 IS - 4 N2 - AIM: To study the anti-tumor bioactive steroid saponins of Paris vietnamensis (Takht.). METHODS: The constituents were isolated and purified by chromatography and their structures were identified by spectral analysis and physicochemical properties. The cytotoxic bioactivities of the constituents were determined by MTT. RESULTS: Eleven compounds were obtained and identified as 3beta, 5alpha,6alpha-trihydroxy-7(8)-en-isospirostanol-3-O-beta-D-glucopyranosyl(1-->3) [alpha-L-rhamnopyranosyl(1-->2)]-beta-D-glucopyranoside (1), which was named as parisvietnaside A, 25 (R) diosgenin-3-O-alpha-L-arabinofuranosyl(1-->4)-beta-D-glucopyranoside (2), 25(R) diosgenin-3-O-alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranoside (3), 25 (R) diosgenin-3-O-alpha-L-arabinofuranosyl (1-->4) [alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glucopyranoside (4), 25 (R) diosgenin-3-O-beta-D-glucopyranosyl (1-->3) [alpha-L-rhamnopyranosyl (1-->2)]-beta-D-glucopyranoside (5), 25 (R) diosgenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl(1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (6), 25 (R) pennogenin-3-O-alpha-L-arabinofuranosyl(1-->4)-beta-D-glucopyranoside (7), 25 (R) pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranoside (8), 25 (R) pennogenin-3-O-alpha-L-arabinofuranosyl (1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (9), 25 (R) pennogenin-3-O-beta-D-glycopyranosyl (1-->3) [alpha-L-rhamnopyranosyl(1-->2)-beta-D-glucopyranoside (10) and 25 (R) pennogenin-3-O-alpha-L-rhamnopyranosyl (1-->4)-alpha-L-rhamnopyranosyl(1-->4) [alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranoside (11). Some constituents had cytotoxic bioactivities. CONCLUSION: Compound 1 is a new spirostanol saponin, and compounds 2, 3, 6-11 were obtained from Paris vietnamensis (Takht.) for the first time. Compounds 3, 4, 6, 8 had cytotoxic bioactivities against tumor cells HepG2 and SGC-7901. SN - 0513-4870 UR - https://www.unboundmedicine.com/medline/citation/16856484/[Separation_and_identification_of_active_constituents_of_Paris_vietnamensis]_ DB - PRIME DP - Unbound Medicine ER -