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Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy.

Abstract

AIM

Little data exist on the impact of chronic low dose corticosteroid therapy during pregnancy on gestational diabetes mellitus (GDM).

METHOD

We compared 25 pregnant women receiving long-term (>4 weeks) corticosteroid for newly diagnosed idiopathic thrombocytopenic purpura (ITP) (study group) and 108 normal pregnant women (control group) in this case-control study. Main outcome measures were 1-h, 50-g and 3-h, 100-g glucose tolerance tests (GTTs). Women in both groups were also screened with 75-g GTT 6 weeks after delivery.

RESULTS

The mean duration of corticosteroid therapy was 9.8+/-4.9 (range 6-25) weeks. Compared with controls, study group patients had a greater prevalence of diagnosed GDM (24.0 vs. 2.8%, P=0.01). Of these patients, 83.3% were diagnosed with GDM at 16 weeks gestation. An impaired 75-g GTT was also more frequent in the study group (P=0.01).

CONCLUSION

Our findings suggest that long-term corticosteroid therapy may be associated with the development of diabetes in pregnant women and early GTT should be performed in pregnant women on corticosteroid therapy.

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  • Authors+Show Affiliations

    ,

    Aegean Obstetrics and Gynecology Training and Research Hospital, Department of Obstetrics and Gynecology, Yenisehir, Izmir, Turkey. dr.yusufyildirim@yahoo.tr

    , , ,

    Source

    MeSH

    Adrenal Cortex Hormones
    Adult
    Case-Control Studies
    Diabetes, Gestational
    Female
    Glucose Tolerance Test
    Humans
    Infant, Newborn
    Pregnancy
    Pregnancy Complications, Hematologic
    Pregnancy Outcome
    Purpura, Thrombocytopenic, Idiopathic
    Time Factors

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16856815

    Citation

    Yildirim, Yusuf, et al. "Gestational Diabetes Mellitus in Patients Receiving Long-term Corticosteroid Therapy During Pregnancy." Journal of Perinatal Medicine, vol. 34, no. 4, 2006, pp. 280-4.
    Yildirim Y, Tinar S, Oner RS, et al. Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy. J Perinat Med. 2006;34(4):280-4.
    Yildirim, Y., Tinar, S., Oner, R. S., Kaya, B., & Toz, E. (2006). Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy. Journal of Perinatal Medicine, 34(4), pp. 280-4.
    Yildirim Y, et al. Gestational Diabetes Mellitus in Patients Receiving Long-term Corticosteroid Therapy During Pregnancy. J Perinat Med. 2006;34(4):280-4. PubMed PMID: 16856815.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gestational diabetes mellitus in patients receiving long-term corticosteroid therapy during pregnancy. AU - Yildirim,Yusuf, AU - Tinar,Sivekar, AU - Oner,Recai Soner, AU - Kaya,Baris, AU - Toz,Emrah, PY - 2006/7/22/pubmed PY - 2007/1/5/medline PY - 2006/7/22/entrez SP - 280 EP - 4 JF - Journal of perinatal medicine JO - J Perinat Med VL - 34 IS - 4 N2 - AIM: Little data exist on the impact of chronic low dose corticosteroid therapy during pregnancy on gestational diabetes mellitus (GDM). METHOD: We compared 25 pregnant women receiving long-term (>4 weeks) corticosteroid for newly diagnosed idiopathic thrombocytopenic purpura (ITP) (study group) and 108 normal pregnant women (control group) in this case-control study. Main outcome measures were 1-h, 50-g and 3-h, 100-g glucose tolerance tests (GTTs). Women in both groups were also screened with 75-g GTT 6 weeks after delivery. RESULTS: The mean duration of corticosteroid therapy was 9.8+/-4.9 (range 6-25) weeks. Compared with controls, study group patients had a greater prevalence of diagnosed GDM (24.0 vs. 2.8%, P=0.01). Of these patients, 83.3% were diagnosed with GDM at 16 weeks gestation. An impaired 75-g GTT was also more frequent in the study group (P=0.01). CONCLUSION: Our findings suggest that long-term corticosteroid therapy may be associated with the development of diabetes in pregnant women and early GTT should be performed in pregnant women on corticosteroid therapy. SN - 0300-5577 UR - https://www.unboundmedicine.com/medline/citation/16856815/full_citation L2 - https://www.degruyter.com/doi/10.1515/JPM.2006.053 DB - PRIME DP - Unbound Medicine ER -