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[Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun; 31(3):359-62.ZN

Abstract

OBJECTIVE

To investigate the therapeutic effects of 4 different treatments for woman polycystic ovarian syndrome (PCOS) with infertility.

METHODS

One hundred and twenty women PCOS with infertility were divided into 4 Groups : patients in Group 1 were directly treated with clomiphene (CC)/CC + human menopausal gonadotropin (HMG) + human chorionic gonadotropin (HCG) to accelerate ovulation; patients in Group 2 were treated with the same way as Group 1 after taking marvolon for 2 cycles; patients in Group 3 took marvolon for 2 cycles and metformin for 8 weeks, and then were treated the same as Group 1; patients in Group 4 were treated with laparosocopy. The body mess index (BMI), emmenia period, weight, volume of ovary, LH, and T were measured before and after the treatment in all patients. The cycle ovulatory rate and occurrence rate of luteinized unruptued follicle syndrome (LUFS) within 2 months and the pregnancy rate within 6 months after the treatment were also observed.

RESULTS

In all patients, BMI, emmenia period, serum T, and serum LH decreased significantly (P <0.05 or 0.01). The body mess indexes were significantly lower in Group 2 and Group 3 than those in Group 4 and Group 1, and Group 4 was also lower than Group 1 (P < 0.05 or 0.01). There was no difference in emmenia period between the 4 groups (P = 0.289). The volumes of ovary were enlarged in Group 1, and they were shrunk in the residual groups, which was significantly lower in Group 4 than in Group 2 and 3 (P < 0.01). The cycle ovulation rates were 53%, 72 %, 78 %, and 76%; the pregnancy rates within 6 months were 20%, 47%, 50%, and 57%, respectively; and they were significantly higher in the Group 2, 3 and 4 than in Group 1 (P <0.01). The occurrence rates of LUFS were 32%, 16%, 15%, and 13%, and they were significantly lower in Group 2, 3 and 4 than in Group 1 (P <0. 01).

CONCLUSION

The effects of marvolon or marvolon and metformin are the same as those of laparoscopy not only in controlling the symptoms of PCOS, but also in increasing the cycle ovulation rate, pregnancy rate within 6 months, and decreasing the occurrence rate of LUFS. The symptoms of PCOS can be controlled better, but the cycle ovulation rate and pregnancy rate within 6 months can not be improved when clomiphene is used alone.

Authors+Show Affiliations

Shi XB
Department of Obstetrics and Gynecology, Second Xiangya Hosptial, Central South University, Changsha, China. shixiaobo8848@yahoo.com.cn
Zhou LY
No affiliation info available
Fu SX
No affiliation info available
Chen JL
No affiliation info available

MeSH

AdultChorionic GonadotropinClomipheneDrug Therapy, CombinationFemaleFertility Agents, FemaleHumansInfertility, FemaleInsulin ResistanceLaparoscopyMetforminOvulation InductionPolycystic Ovary Syndrome

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16859124

Citation

Shi, Xiao-bo, et al. "[Clinical Analysis of 4 Treatments for Woman Polycystic Ovarian Syndrome With Infertility]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 31, no. 3, 2006, pp. 359-62.
Shi XB, Zhou LY, Fu SX, et al. [Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(3):359-62.
Shi, X. B., Zhou, L. Y., Fu, S. X., & Chen, J. L. (2006). [Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 31(3), 359-62.
Shi XB, et al. [Clinical Analysis of 4 Treatments for Woman Polycystic Ovarian Syndrome With Infertility]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(3):359-62. PubMed PMID: 16859124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical analysis of 4 treatments for woman polycystic ovarian syndrome with infertility]. AU - Shi,Xiao-bo, AU - Zhou,Li-yuan, AU - Fu,Shu-xin, AU - Chen,Jian-lin, PY - 2006/7/25/pubmed PY - 2007/3/21/medline PY - 2006/7/25/entrez SP - 359 EP - 62 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 31 IS - 3 N2 - OBJECTIVE: To investigate the therapeutic effects of 4 different treatments for woman polycystic ovarian syndrome (PCOS) with infertility. METHODS: One hundred and twenty women PCOS with infertility were divided into 4 Groups : patients in Group 1 were directly treated with clomiphene (CC)/CC + human menopausal gonadotropin (HMG) + human chorionic gonadotropin (HCG) to accelerate ovulation; patients in Group 2 were treated with the same way as Group 1 after taking marvolon for 2 cycles; patients in Group 3 took marvolon for 2 cycles and metformin for 8 weeks, and then were treated the same as Group 1; patients in Group 4 were treated with laparosocopy. The body mess index (BMI), emmenia period, weight, volume of ovary, LH, and T were measured before and after the treatment in all patients. The cycle ovulatory rate and occurrence rate of luteinized unruptued follicle syndrome (LUFS) within 2 months and the pregnancy rate within 6 months after the treatment were also observed. RESULTS: In all patients, BMI, emmenia period, serum T, and serum LH decreased significantly (P <0.05 or 0.01). The body mess indexes were significantly lower in Group 2 and Group 3 than those in Group 4 and Group 1, and Group 4 was also lower than Group 1 (P < 0.05 or 0.01). There was no difference in emmenia period between the 4 groups (P = 0.289). The volumes of ovary were enlarged in Group 1, and they were shrunk in the residual groups, which was significantly lower in Group 4 than in Group 2 and 3 (P < 0.01). The cycle ovulation rates were 53%, 72 %, 78 %, and 76%; the pregnancy rates within 6 months were 20%, 47%, 50%, and 57%, respectively; and they were significantly higher in the Group 2, 3 and 4 than in Group 1 (P <0.01). The occurrence rates of LUFS were 32%, 16%, 15%, and 13%, and they were significantly lower in Group 2, 3 and 4 than in Group 1 (P <0. 01). CONCLUSION: The effects of marvolon or marvolon and metformin are the same as those of laparoscopy not only in controlling the symptoms of PCOS, but also in increasing the cycle ovulation rate, pregnancy rate within 6 months, and decreasing the occurrence rate of LUFS. The symptoms of PCOS can be controlled better, but the cycle ovulation rate and pregnancy rate within 6 months can not be improved when clomiphene is used alone. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/16859124/[Clinical_analysis_of_4_treatments_for_woman_polycystic_ovarian_syndrome_with_infertility]_ DB - PRIME DP - Unbound Medicine ER -

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