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[Cerebral state index the in monitoring and evaluating the induction of anesthesia with target-controlled infusion of propofol in adults].
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Jun; 31(3):437-40.ZN

Abstract

OBJECTIVE

To evaluate the accuracy of cerebral state index (CSI) as an indicator of anesthesia depth in patients in the induction of anesthesia with target-controlled infusion of propofol.

METHODS

Forty ASA (American Society of Anesthesiologists) I approximately II patients scheduled for an operation under general anesthesia were anesthetized with target-controlled infusion of propofol. Target plasma concentration was 0. 5 mg/L at the beginning, and increased by 0. 5 mg/L every 5 minutes, till 5 minutes after the level of MOAA/S (modified observer's assessment of alertness/sedation) was 0. The CSI, mean arterial pressure (MAP), heart rate (HR), MOAA/S level, and the effect-site concentration of propofol were recorded.

RESULTS

(1) CSI values declined with the decrease of MOAA/S levels. CSI values were statistically different between level 0 and 1, level 1 and 2, level 3 and 4, level 4 and 5 of MOAA/S (P < 0.05). The difference of MAP had statistical significance between level 3 and level 2 of MOAA/S (P < 0.05). HR values had no statistical difference between the two levels of MOAA/S (P > 0.05). (2) The spearman rank correlation co-efficients between CSI, MAP, HR and the level of MOAA/S were 0.929, 0.421, and 0.085, respectively. The prediction probabilities (Pk) to differentiate different levels of MOAA/S for CSI, MAP, and HR were 0.94, 0.67, and 0.54, respectively. (3) There was linear regression relationship between CSI and the effect-site concentration of propofol (the coefficient of determination R2 was 0. 833, P < 0.01).

CONCLUSION

During the induction of patients with target-controlled infusion of propofol, the CSI is accurate as an indicator of awakeness and different levels of consciousness after anesthesia, and can reliably predict the anesthesia depth.

Authors+Show Affiliations

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

16859144

Citation

Pan, Yun-dan, et al. "[Cerebral State Index the in Monitoring and Evaluating the Induction of Anesthesia With Target-controlled Infusion of Propofol in Adults]." Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, vol. 31, no. 3, 2006, pp. 437-40.
Pan YD, Guo QL, Zhong T. [Cerebral state index the in monitoring and evaluating the induction of anesthesia with target-controlled infusion of propofol in adults]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(3):437-40.
Pan, Y. D., Guo, Q. L., & Zhong, T. (2006). [Cerebral state index the in monitoring and evaluating the induction of anesthesia with target-controlled infusion of propofol in adults]. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences, 31(3), 437-40.
Pan YD, Guo QL, Zhong T. [Cerebral State Index the in Monitoring and Evaluating the Induction of Anesthesia With Target-controlled Infusion of Propofol in Adults]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006;31(3):437-40. PubMed PMID: 16859144.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cerebral state index the in monitoring and evaluating the induction of anesthesia with target-controlled infusion of propofol in adults]. AU - Pan,Yun-dan, AU - Guo,Qu-lian, AU - Zhong,Tao, PY - 2006/7/25/pubmed PY - 2007/3/21/medline PY - 2006/7/25/entrez SP - 437 EP - 40 JF - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JO - Zhong Nan Da Xue Xue Bao Yi Xue Ban VL - 31 IS - 3 N2 - OBJECTIVE: To evaluate the accuracy of cerebral state index (CSI) as an indicator of anesthesia depth in patients in the induction of anesthesia with target-controlled infusion of propofol. METHODS: Forty ASA (American Society of Anesthesiologists) I approximately II patients scheduled for an operation under general anesthesia were anesthetized with target-controlled infusion of propofol. Target plasma concentration was 0. 5 mg/L at the beginning, and increased by 0. 5 mg/L every 5 minutes, till 5 minutes after the level of MOAA/S (modified observer's assessment of alertness/sedation) was 0. The CSI, mean arterial pressure (MAP), heart rate (HR), MOAA/S level, and the effect-site concentration of propofol were recorded. RESULTS: (1) CSI values declined with the decrease of MOAA/S levels. CSI values were statistically different between level 0 and 1, level 1 and 2, level 3 and 4, level 4 and 5 of MOAA/S (P < 0.05). The difference of MAP had statistical significance between level 3 and level 2 of MOAA/S (P < 0.05). HR values had no statistical difference between the two levels of MOAA/S (P > 0.05). (2) The spearman rank correlation co-efficients between CSI, MAP, HR and the level of MOAA/S were 0.929, 0.421, and 0.085, respectively. The prediction probabilities (Pk) to differentiate different levels of MOAA/S for CSI, MAP, and HR were 0.94, 0.67, and 0.54, respectively. (3) There was linear regression relationship between CSI and the effect-site concentration of propofol (the coefficient of determination R2 was 0. 833, P < 0.01). CONCLUSION: During the induction of patients with target-controlled infusion of propofol, the CSI is accurate as an indicator of awakeness and different levels of consciousness after anesthesia, and can reliably predict the anesthesia depth. SN - 1672-7347 UR - https://www.unboundmedicine.com/medline/citation/16859144/[Cerebral_state_index_the_in_monitoring_and_evaluating_the_induction_of_anesthesia_with_target_controlled_infusion_of_propofol_in_adults]_ L2 - http://xbyxb.csu.edu.cn/xbwk/fileup/PDF/200606437.pdf DB - PRIME DP - Unbound Medicine ER -