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Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats.

Abstract

Hyperglycemia induced oxidative stress has been proposed as a cause of many complications of diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of green tea extract on oxidative stress in aorta as well as heart of streptozotocin diabetic rats. Six weeks after diabetes induction, green tea was administered orally for 4 weeks [300 mg (kg body weight)(-1) day (-1)]. In aorta and heart of diabetic rats there was a significant increase in the activity of superoxide dismutase, catalase and glutathione peroxidase with an increase in lipid peroxides. Diabetic rats showed a significant decrease in the levels of serum and cardiac glutathione. Green tea administration to diabetic rats reduced lipid peroxides and activity of antioxidant enzymes whereas increased glutathione content. The results demonstrate that the induction of antioxidant enzymes in diabetic rats is not efficient and sufficient to reduce the oxidative stress. But green tea by providing a competent antioxidative mechanism ameliorates the oxidative stress in the aorta and heart of diabetic rats. The study suggests that green tea may provide a useful therapeutic option in the reversal of oxidative stress induced cardiac dysfunction in diabetes mellitus.

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  • Authors+Show Affiliations

    ,

    Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.

    ,

    Source

    Chemico-biological interactions 162:2 2006 Aug 25 pg 114-20

    MeSH

    Administration, Oral
    Animals
    Antioxidants
    Aorta
    Behavior, Animal
    Blood Glucose
    Body Weight
    Camellia sinensis
    Catalase
    Catechin
    Diabetes Mellitus, Experimental
    Glutathione
    Glutathione Peroxidase
    Heart
    Lipid Peroxidation
    Lipid Peroxides
    Male
    Myocardium
    Oxidative Stress
    Phytotherapy
    Plant Extracts
    Plant Leaves
    Rats
    Rats, Wistar
    Superoxide Dismutase

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16860299

    Citation

    Babu, Pon Velayutham Anandh, et al. "Therapeutic Effect of Green Tea Extract On Oxidative Stress in Aorta and Heart of Streptozotocin Diabetic Rats." Chemico-biological Interactions, vol. 162, no. 2, 2006, pp. 114-20.
    Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chem Biol Interact. 2006;162(2):114-20.
    Babu, P. V., Sabitha, K. E., & Shyamaladevi, C. S. (2006). Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chemico-biological Interactions, 162(2), pp. 114-20.
    Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic Effect of Green Tea Extract On Oxidative Stress in Aorta and Heart of Streptozotocin Diabetic Rats. Chem Biol Interact. 2006 Aug 25;162(2):114-20. PubMed PMID: 16860299.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. AU - Babu,Pon Velayutham Anandh, AU - Sabitha,Kuruvimalai Ekambaram, AU - Shyamaladevi,Chennam Srinivasulu, Y1 - 2006/04/28/ PY - 2006/02/18/received PY - 2006/04/10/revised PY - 2006/04/21/accepted PY - 2006/7/25/pubmed PY - 2006/10/31/medline PY - 2006/7/25/entrez SP - 114 EP - 20 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 162 IS - 2 N2 - Hyperglycemia induced oxidative stress has been proposed as a cause of many complications of diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of green tea extract on oxidative stress in aorta as well as heart of streptozotocin diabetic rats. Six weeks after diabetes induction, green tea was administered orally for 4 weeks [300 mg (kg body weight)(-1) day (-1)]. In aorta and heart of diabetic rats there was a significant increase in the activity of superoxide dismutase, catalase and glutathione peroxidase with an increase in lipid peroxides. Diabetic rats showed a significant decrease in the levels of serum and cardiac glutathione. Green tea administration to diabetic rats reduced lipid peroxides and activity of antioxidant enzymes whereas increased glutathione content. The results demonstrate that the induction of antioxidant enzymes in diabetic rats is not efficient and sufficient to reduce the oxidative stress. But green tea by providing a competent antioxidative mechanism ameliorates the oxidative stress in the aorta and heart of diabetic rats. The study suggests that green tea may provide a useful therapeutic option in the reversal of oxidative stress induced cardiac dysfunction in diabetes mellitus. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/16860299/Therapeutic_effect_of_green_tea_extract_on_oxidative_stress_in_aorta_and_heart_of_streptozotocin_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(06)00104-9 DB - PRIME DP - Unbound Medicine ER -