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Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats.
Chem Biol Interact 2006; 162(2):114-20CB

Abstract

Hyperglycemia induced oxidative stress has been proposed as a cause of many complications of diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of green tea extract on oxidative stress in aorta as well as heart of streptozotocin diabetic rats. Six weeks after diabetes induction, green tea was administered orally for 4 weeks [300 mg (kg body weight)(-1) day (-1)]. In aorta and heart of diabetic rats there was a significant increase in the activity of superoxide dismutase, catalase and glutathione peroxidase with an increase in lipid peroxides. Diabetic rats showed a significant decrease in the levels of serum and cardiac glutathione. Green tea administration to diabetic rats reduced lipid peroxides and activity of antioxidant enzymes whereas increased glutathione content. The results demonstrate that the induction of antioxidant enzymes in diabetic rats is not efficient and sufficient to reduce the oxidative stress. But green tea by providing a competent antioxidative mechanism ameliorates the oxidative stress in the aorta and heart of diabetic rats. The study suggests that green tea may provide a useful therapeutic option in the reversal of oxidative stress induced cardiac dysfunction in diabetes mellitus.

Authors+Show Affiliations

Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16860299

Citation

Babu, Pon Velayutham Anandh, et al. "Therapeutic Effect of Green Tea Extract On Oxidative Stress in Aorta and Heart of Streptozotocin Diabetic Rats." Chemico-biological Interactions, vol. 162, no. 2, 2006, pp. 114-20.
Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chem Biol Interact. 2006;162(2):114-20.
Babu, P. V., Sabitha, K. E., & Shyamaladevi, C. S. (2006). Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. Chemico-biological Interactions, 162(2), pp. 114-20.
Babu PV, Sabitha KE, Shyamaladevi CS. Therapeutic Effect of Green Tea Extract On Oxidative Stress in Aorta and Heart of Streptozotocin Diabetic Rats. Chem Biol Interact. 2006 Aug 25;162(2):114-20. PubMed PMID: 16860299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effect of green tea extract on oxidative stress in aorta and heart of streptozotocin diabetic rats. AU - Babu,Pon Velayutham Anandh, AU - Sabitha,Kuruvimalai Ekambaram, AU - Shyamaladevi,Chennam Srinivasulu, Y1 - 2006/04/28/ PY - 2006/02/18/received PY - 2006/04/10/revised PY - 2006/04/21/accepted PY - 2006/7/25/pubmed PY - 2006/10/31/medline PY - 2006/7/25/entrez SP - 114 EP - 20 JF - Chemico-biological interactions JO - Chem. Biol. Interact. VL - 162 IS - 2 N2 - Hyperglycemia induced oxidative stress has been proposed as a cause of many complications of diabetes including cardiac dysfunction. The present study depicts the therapeutic effect of green tea extract on oxidative stress in aorta as well as heart of streptozotocin diabetic rats. Six weeks after diabetes induction, green tea was administered orally for 4 weeks [300 mg (kg body weight)(-1) day (-1)]. In aorta and heart of diabetic rats there was a significant increase in the activity of superoxide dismutase, catalase and glutathione peroxidase with an increase in lipid peroxides. Diabetic rats showed a significant decrease in the levels of serum and cardiac glutathione. Green tea administration to diabetic rats reduced lipid peroxides and activity of antioxidant enzymes whereas increased glutathione content. The results demonstrate that the induction of antioxidant enzymes in diabetic rats is not efficient and sufficient to reduce the oxidative stress. But green tea by providing a competent antioxidative mechanism ameliorates the oxidative stress in the aorta and heart of diabetic rats. The study suggests that green tea may provide a useful therapeutic option in the reversal of oxidative stress induced cardiac dysfunction in diabetes mellitus. SN - 0009-2797 UR - https://www.unboundmedicine.com/medline/citation/16860299/Therapeutic_effect_of_green_tea_extract_on_oxidative_stress_in_aorta_and_heart_of_streptozotocin_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(06)00104-9 DB - PRIME DP - Unbound Medicine ER -