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C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO.
Mech Ageing Dev 2006; 127(9):741-7MA

Abstract

14-3-3 proteins are evolutionarily conserved and ubiquitous proteins that function in a wide variety of biological processes. Here we define a new role for C. elegans 14-3-3 proteins in life span regulation. We identify two C. elegans 14-3-3 proteins as interacting proteins of a major life span regulator, the C. elegans SIR2 ortholog, SIR-2.1. Similar to sir-2.1, we find that overexpression of either 14-3-3 protein (PAR-5 or FTT-2) extends life span and that this is dependent on DAF-16, a forkhead transcription factor (FOXO), another important life span regulator in the insulin/IGF-1 signaling pathway. Furthermore, we show that both 14-3-3 proteins are co-expressed with DAF-16 and SIR-2.1 in the tissues critical for life span regulation. Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO.

Authors+Show Affiliations

Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01605, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16860373

Citation

Wang, Yamei, et al. "C. Elegans 14-3-3 Proteins Regulate Life Span and Interact With SIR-2.1 and DAF-16/FOXO." Mechanisms of Ageing and Development, vol. 127, no. 9, 2006, pp. 741-7.
Wang Y, Oh SW, Deplancke B, et al. C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev. 2006;127(9):741-7.
Wang, Y., Oh, S. W., Deplancke, B., Luo, J., Walhout, A. J., & Tissenbaum, H. A. (2006). C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mechanisms of Ageing and Development, 127(9), pp. 741-7.
Wang Y, et al. C. Elegans 14-3-3 Proteins Regulate Life Span and Interact With SIR-2.1 and DAF-16/FOXO. Mech Ageing Dev. 2006;127(9):741-7. PubMed PMID: 16860373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. AU - Wang,Yamei, AU - Oh,Seung Wook, AU - Deplancke,Bart, AU - Luo,Jianyuan, AU - Walhout,Albertha J M, AU - Tissenbaum,Heidi A, Y1 - 2006/07/24/ PY - 2006/03/08/received PY - 2006/05/18/revised PY - 2006/05/31/accepted PY - 2006/7/25/pubmed PY - 2006/10/18/medline PY - 2006/7/25/entrez SP - 741 EP - 7 JF - Mechanisms of ageing and development JO - Mech. Ageing Dev. VL - 127 IS - 9 N2 - 14-3-3 proteins are evolutionarily conserved and ubiquitous proteins that function in a wide variety of biological processes. Here we define a new role for C. elegans 14-3-3 proteins in life span regulation. We identify two C. elegans 14-3-3 proteins as interacting proteins of a major life span regulator, the C. elegans SIR2 ortholog, SIR-2.1. Similar to sir-2.1, we find that overexpression of either 14-3-3 protein (PAR-5 or FTT-2) extends life span and that this is dependent on DAF-16, a forkhead transcription factor (FOXO), another important life span regulator in the insulin/IGF-1 signaling pathway. Furthermore, we show that both 14-3-3 proteins are co-expressed with DAF-16 and SIR-2.1 in the tissues critical for life span regulation. Finally, we show that DAF-16/FOXO also physically interacts with the 14-3-3 proteins. These results suggest that C. elegans 14-3-3 proteins can regulate longevity by cooperating with both SIR-2.1 and DAF-16/FOXO. SN - 0047-6374 UR - https://www.unboundmedicine.com/medline/citation/16860373/C__elegans_14_3_3_proteins_regulate_life_span_and_interact_with_SIR_2_1_and_DAF_16/FOXO_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0047-6374(06)00144-8 DB - PRIME DP - Unbound Medicine ER -